Diffusion-weighted magnetic resonance for prediction of response after neoadjuvant chemoradiation therapy for locally advanced rectal cancer: Preliminary results of a monoinstitutional prospective study

Genovesi, Domenico; Filippone, Antonella; Cèfaro, Giampiero Ausili; Trignani, Marianna; Vinciguerra, A.; Augurio, Antonietta; Tommaso, M. Di; Borzillo, Valentina; Sabatino, Fabiana Di; Innocenti, Paolo; Liberatore, E; Colecchia, G; Tartaro, Armando; Cotroneo, Antonio Raffaele

doi:10.1016/j.ejso.2013.07.090

Cited by 66 publications

(74 citation statements)

References 29 publications

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“…Sun et al (10) Intven et al (11) Lambrecht et al (12) Barbaro et al (13) Kim et al (14) Genovesi et al (15) Kim et al (16) Monguzzi et al (17) Elmi et al (18) No. …”

Section: Refunclassified

“…In a recent study, ADC for predicting response was confirmed using the area under the receiver-operating characteristic (ROC) curve analysis with a sensitivity of 75% and specificity of 48% (13). Despite the promising results, there is no consensus whether low ADC-pre value should be used as a predictor for response to CRT because in some studies the ADC-pre value could not reliably discriminate CR from non-CR (14,15). Therefore, relying on ADC-pre seems to be insufficient to select in advance poor responders who might need to undergo early surgery.…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

“…Sun et al observed that the ΔADC was significantly higher in the T-downstaged group than that in the nondownstaged group (p < 0.001) (10). An increase of ADC had a high positive predictive value for pCR (11,15). During treatment, the mean percentage of ADC increase was significantly greater in the responders than nonresponders (p < 0.0001) and a > 23% ADC increase had a negative predictive value of 96.3% for TRG4 (18).…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

“…Regarding the post-CRT ADC value (ADC-post) as a predictor for response, several studies showed that it could differentiate patients with pCR from those without (14,15,17). Moreover ADC-post value measurements are reliable and reproducible (17).…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

“…The ADC is related to tissue cellularity, tissue organization, extracellular space tortuosity, tumor proliferation, tumor grade, and tumor necrosis (9)(10)(11). With respect to ADC as a quantitative biomarker in rectal cancer, several investigations have reported promising results for the prediction and monitoring of therapeutic responses (10)(11)(12)(13)(14)(15)(16)(17)(18) (Table 1).…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

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Prediction of response to preoperative chemoradiotherapy in patients with locally advanced rectal cancer

Meng

Huang

Wang

et al. 2014

BST

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“…Sun et al (10) Intven et al (11) Lambrecht et al (12) Barbaro et al (13) Kim et al (14) Genovesi et al (15) Kim et al (16) Monguzzi et al (17) Elmi et al (18) No. …”

Section: Refunclassified

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

See 3 more Smart Citations

Prediction of response to preoperative chemoradiotherapy in patients with locally advanced rectal cancer

Meng

Huang

Wang

et al. 2014

BST

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Diffusion‐weighted imaging: Apparent diffusion coefficient histogram analysis for detecting pathologic complete response to chemoradiotherapy in locally advanced rectal cancer

Choi

Rha

et al. 2015

Magnetic Resonance Imaging

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Purpose: To investigate the usefulness of apparent diffusion coefficient (ADC) values derived from histogram analysis of the whole rectal cancer as a quantitative parameter to evaluate pathologic complete response (pCR) on preoperative magnetic resonance imaging (MRI). Materials and Methods: We enrolled a total of 86 consecutive patients who had undergone surgery for rectal cancer after neoadjuvant chemoradiotherapy (CRT) at our institution between July 2012 and November 2014. Two radiologists who were blinded to the final pathological results reviewed post-CRT MRI to evaluate tumor stage. Quantitative image analysis was performed using T 2 -weighted and diffusion-weighted images independently by two radiologists using dedicated software that performed histogram analysis to assess the distribution of ADC in the whole tumor. Results: After surgery, 16 patients were confirmed to have achieved pCR (18.6%). All parameters from pre-and post-CRT ADC histogram showed good or excellent agreement between two readers. The minimum, 10th, 25th, 50th, and 75th percentile and mean ADC from post-CRT ADC histogram were significantly higher in the pCR group than in the non-pCR group for both readers. The 25th percentile value from ADC histogram in post-CRT MRI had the best diagnostic performance for detecting pCR, with an area under the receiver operating characteristic curve of 0.796. Conclusion: Low percentile values derived from the ADC histogram analysis of rectal cancer on MRI after CRT showed a significant difference between pCR and non-pCR groups, demonstrating the utility of the ADC value as a quantitative and objective marker to evaluate complete pathologic response to preoperative CRT in rectal cancer.

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Quantitative intravoxel incoherent motion parameters derived from whole‐tumor volume for assessing pathological complete response to neoadjuvant chemotherapy in locally advanced rectal cancer

Sun

et al. 2017

Magnetic Resonance Imaging

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Diffusion-weighted magnetic resonance for prediction of response after neoadjuvant chemoradiation therapy for locally advanced rectal cancer: Preliminary results of a monoinstitutional prospective study

Cited by 66 publications

References 29 publications

Prediction of response to preoperative chemoradiotherapy in patients with locally advanced rectal cancer

Prediction of response to preoperative chemoradiotherapy in patients with locally advanced rectal cancer

Diffusion‐weighted imaging: Apparent diffusion coefficient histogram analysis for detecting pathologic complete response to chemoradiotherapy in locally advanced rectal cancer

Quantitative intravoxel incoherent motion parameters derived from whole‐tumor volume for assessing pathological complete response to neoadjuvant chemotherapy in locally advanced rectal cancer

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