Diffusion-weighted imaging in rectal carcinoma patients without and after chemoradiotherapy: A comparative study with histology

Evaluation of a Simplified Intravoxel Incoherent Motion (IVIM) Analysis of Diffusion-Weighted Imaging for Prediction of Tumor Size Changes and Imaging Response in Breast Cancer Liver Metastases Undergoing Radioembolization

“…29–31,38,40 In tumors, lower f-values correlated with a lower histological microvessel density 41 and with a lower histological vascular area fraction. 42 Blood vessels in malignant tumors also tend to be immature and leaky, thus contributing to a high intralesional interstitial fluid pressure and subsequent slow blood flow, 43,44 which causes low D ∗ -values. Viable tumor tissue showed significantly lower diffusion coefficients D and higher perfusion fractions f than necrotic areas.…”

Correlations between intravoxel incoherent motion (IVIM) parameters and histological findings in rectal cancer: preliminary results

“…In rectal cancer, only few studies investigated associations between DWI findings and histopathology [23, 24]. Furthermore, the reported data were contradictory.…”

“…For instance, Sun et al found a significant correlation between ADC values and KI 67 level in rectal cancer [23]. Bäuerle et al, however, showed that IVIM parameters correlated with vascular density, but not with cellularity [24]. …”

Colorectal Cancer

“…Perfusion component dominates the signal decay at low b -values, a feature that enables a differentiation between the perfusion fraction ( f ) and perfusion-free diffusion ( D ). For patients with RC, the perfusion fraction f correlated with the vascular area fraction (percentage of CD 31 positive area on histological sections), but surprisingly the perfusion f was signifi cantly higher in the normal rectum wall, and no correlation between diffusion and cellularity could be detected for rectal tumors [ 53 ].…”