Diffusion-weighted imaging: As the first diagnostic clue to Creutzfeldt Jacob disease

Kumaran, Sunitha P; Gupta, Kanchan; Pushpa, BT; Viswamitra, Sanjaya; V., Joshy E.

doi:10.4103/0976-3147.102645

Cited by 4 publications

(4 citation statements)

References 7 publications

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“…Less frequently, periaqueductal grey matter hyperintensity in FLAIR images has been reported, which was present on the MRI of our patient [ 22 , 23 ]. In recent years, the DWI sequence was reported as the most sensitive in CJD, and often the cortical diffusion restriction is the first clue in CJD [ 24 ]. Moreover, the disease progression can also be monitored using the DWI sequence [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Histopathologically Confirmed Creutzfeldt–Jakob Disease from Romania, Long Route to Diagnosis—Case Report and an Overview of the Romanian CJD Situation

Kelemen

Kövecsi

Banias

et al. 2022

JCM

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Creutzfeldt–Jacob disease is a progressive and ultimately fatal disease, representing one of the most common forms of prion diseases. It is a rare pathology presenting with various symptomatology, and the fact that a definite diagnosis can be obtained solely by neuropathological techniques makes it hard to recognize and diagnose. Here we present the clinical and neuropathological features of a 72-year-old woman, who originally presented in a county hospital, then, along with the disease progression, got transferred to a university center in Romania, where CJD-specific tests are rarely performed, and ultimately was diagnosed with the help of international collaboration. The purpose of this case report and review is to summarize the Romanian CJD situation until the present day, to place the Romanian CJD epidemiology in an Eastern European context, and to highlight the diagnostic options and possibilities for clinical practitioners. We would also like to draw attention to the need for a national surveillance system. By presenting the patient’s route in Romania from the first presentation to diagnosis, we would like to emphasize the importance of interdisciplinary and international collaboration, by which we managed to cross the regional diagnostic boundaries and create a possible diagnostic pathway for future cases.

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Section: Discussionmentioning

confidence: 99%

A Rare Case of Histopathologically Confirmed Creutzfeldt–Jakob Disease from Romania, Long Route to Diagnosis—Case Report and an Overview of the Romanian CJD Situation

Kelemen

Kövecsi

Banias

et al. 2022

JCM

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“…Clinical applications are also in a wide range in both diagnostic and therapeutic purposes. For the diagnostic purpose, the researches on dMRI-based detection and staging of diseases and disorders cover various targets, such as stroke, 11 infarction, 12 tumors, 13 multiple sclerosis, 14 Parkinson’s disease, 15 Alzheimer disease, 16 Creutzfeldt-Jakob disease, 17 and so on. To realize minimally invasive surgery and radiotherapy, information on the white matter fiber tracts helps planning and navigation.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Parameter Inference for Diffusion MRI Signal Models

Masutani

2022

magn reson med sci

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In this paper, fundamentals and recent progress for obtaining biological features quantitatively by using diffusion MRI are reviewed. First, a brief description of diffusion MRI history, application, and development was presented. Then, well-known parametric models including diffusion tensor imaging (DTI), diffusional kurtosis imaging (DKI), and neurite orientation dispersion diffusion imaging (NODDI) are introduced with several classifications in various viewpoints with other modeling schemes. In addition, this review covers mathematical generalization and examples of methodologies for the model parameter inference from conventional fitting to recent machine learning approaches, which is called Q-space learning (QSL). Finally, future perspectives on diffusion MRI parameter inference are discussed with the aspects of imaging modeling and simulation.

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“…Orta-ileri yaşlarda başlayan hastalık hızlı ilerleyen demans, miyokloni ve psikiyatrik bozukluklar ile kendini gösterir 1,2 . Kesin tanı beyin biyopsisi ile koyulsa da invaziv ve ciddi komplikasyonları olan bir yöntem olduğu için tanı da sıkça kullanılmamaktadır.…”

Section: Introductionunclassified

“…Sponjiform ensefalopati grubunda yer alan ve bir prion hastalığı olan Creutzfeldt-Jacob hastalığının (CJH) yıllıkgörülmesıklığı 0.5-1/ milyon'dur. Orta-ileri yaşlarda başlayan hastalık hızlı ilerleyen demans, miyokloni ve psikiyatrik bozukluklar ile kendini gösterir 1,2…”

Section: Introductionunclassified

Sporadik Creutzfeldt-Jakob hastalığında difüzyon MR görüntüleme

Peköz¹,

Alkan²,

Gıray³

et al. 2014

Cukurova Medical Journal

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NörolojiAnabilimDalları, ADANA CukurovaMedicalJournal 2014;39(4):880-883. ÖZETCreutzfeldt-Jakob hastalığı (CJH) nadir görülen progresif demansiyel bir prion hastalığıdır.Hızl ıilerleyen demans, ataksi, miyoklonus, akinetik mutizm ve sonrasında ölüm ile karakterizedir. Kesin tanıya beyin biyopsisi veya otopsi ile ulaşılabilir.Difüzyon ağırlıklı görüntüleme yüksek sensitivitesi nedeniyle CJH tanısında oldukça önemli bir tanı yöntemidir. Bu makalede olası sporadik CJH tanısı konan ve tipik MR görüntüleme bulguları olan 59 yaşındaki kadın olgu sunulmuştur. AnahtarKelimeler:Bazal gangliyonlar, Creutzfeldt-Jakob hastalığı, Difüzyon MRG ABSTRACTCreutzfeldt-Jakob disease (CJD) is a rare dementing disease and is thought to caused by a prion. It is characterized by rapidly progressive dementia, ataxia, myoclonus, akineticmutism and eventual death. Brain biopsy or autopsy is required for a definitive diagnosis of CJD. Diffusion-weighted imaging became an important tool for early diagnosis of CJD because of the high sensitivity. We present 59-year-old female patient diagnosed as sporadic CJD with typical MR imagings.

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Diffusion-weighted imaging: As the first diagnostic clue to Creutzfeldt Jacob disease

Cited by 4 publications

References 7 publications

A Rare Case of Histopathologically Confirmed Creutzfeldt–Jakob Disease from Romania, Long Route to Diagnosis—Case Report and an Overview of the Romanian CJD Situation

A Rare Case of Histopathologically Confirmed Creutzfeldt–Jakob Disease from Romania, Long Route to Diagnosis—Case Report and an Overview of the Romanian CJD Situation

Recent Advances in Parameter Inference for Diffusion MRI Signal Models

Sporadik Creutzfeldt-Jakob hastalığında difüzyon MR görüntüleme

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