Diffusion-weighted imaging and positron emission tomography in various cytological subtypes of primary lung adenocarcinoma

The Cytomorphological Characteristics of Non-small Cell Lung Cancer are Associated with Its Radiological Features

“…The results of our previous study [12] which revealed a significantly positive correlation between the Ki67 labeling index and the SUV max were consistent with their finding. Our study suggests that the cytological factors solid type ADC with predominant 3D clusters and conspicuous nucleoli with a necrotic background predicted the presence of a solid nodule on CT and a high SUV max on PET, and that SQCC has the same radiological features.…”

“…Thus, their results are similar to the results of the present study in which the SUV max values of solid ADC and SQCC were higher than the values in nonsolid ADC. In our previous study, [12] the SUV max of poorly differentiated ADC (the same as solid adenocarcinoma with mucin) with malignant potential was significantly higher in comparison to the other cytological subtypes (classified by Shimosato's classification [18]). Sauter et al [19] investigated the correlation between the glucose metabolism registered by 18F-FDG PET/CT and tumor perfusion quantified based on volume perfusion CT and immunohistochemical markers (Ki67 and microvessel density [MVD]), which were evaluated by CD34 staining in 24 consecutive NSCLC patients.…”

“…Moreover, studies on PET have shown that the maximum standardized uptake value (SUV max) is an indicator of the potential for cancer cell proliferation, and the increased expression of cell proliferative biomarkers is associated with a worse prognosis in lung cancer [8,9]. Our previous study revealed that diffusion weighted imaging, which is one of the MRI sequences, might reflect the histological and cytomorphological characteristics of tumor cells [10,11], while PET only reflected poorly differentiated cancer cells in surgically resected ADC [12]. The purpose of this study was to retrospectively evaluate the characteristic differences between the cytomorphological findings with the histological subtypes of the bronchoscopic materials and the radiological features of HRCT and PET in the preoperative setting based on our database.…”

A Population-Based Gaussian Mixture Model Incorporating 18F-FDG PET and Diffusion-Weighted MRI Quantifies Tumor Tissue Classes

“…This implicates a complex link between glucose consumption and many opposing factors involved in the multifaceted tumor microenvironment. Moreover, 18 F-FDG can potentially stage tumors in patients with histologically verified NSCLC (10)(11)(12), and changes in 18 F-FDG uptake after therapeutic intervention are correlated to patient prognosis (13)(14)(15), possibly predicting response (14). Adding biologic information measured with DWI might further improve staging and help decide on patient-individualized therapies for treating noninvasive adenocarcinomas (15).…”

PET/MRI in Lung Cancer

“…31 In addition, SI of DWI can differentiate the cell differentiation and subtypes of lung adenocarcinomas. 32,33 With DWI, pooled sensitivity and specificity were 84% in distinguishing benign and malignant nodules in a metaanalysis of 10 studies with 586 nodules 34 and 80% sensitivity and 93% specificity in another meta-analysis of 755 malignant and 294 benign pulmonary nodules. 35 ADC mean exhibited a significant inverse correlation with SUV max as well as with SUVmean assessed by FDG-PET/MRI in NSCLC.…”