Diffusion‐weighted chemical shift imaging of human brain metabolites at 7T

Ercan, Ece; Techawiboonwong, Aranee; Versluis, Mieke; Webb, Andrew; Ronen, Itamar

doi:10.1002/mrm.25346

Cited by 21 publications

(46 citation statements)

References 41 publications

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“…Approaches that use navigators, i.e. short time-domain signal acquired after the diffusion encoding but prior to the spatial encoding, have been proposed and implemented on clinical scanners (159,160), but robustness and sensitivity to disease effects has yet to be demonstrated. Efforts to shorten acquisition time would thus benefit from the use of parallel imaging (161), and if SNR is high enough, perhaps a degree of compressed sensing (162,163).…”

Section: Multivoxel Dw-mrs and Dw-mrsimentioning

confidence: 99%

Insights into brain microstructure from in vivo DW-MRS

et al. 2018

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Many developmental processes, such as plasticity and aging, or pathological processes such as neurological diseases are characterized by modulations of specific cellular types and their microstructures. Diffusion-weighted Magnetic Resonance Imaging (DW-MRI) is a powerful technique for probing microstructure, yet its information arises from the ubiquitous, non-specific water signal. By contrast, diffusion-weighted Magnetic Resonance Spectroscopy (DW-MRS) allows specific characterizations of tissues such as brain and muscle in vivo by quantifying the diffusion properties of MR-observable metabolites. Many brain metabolites are predominantly intracellular, and some of them are preferentially localized in specific brain cell populations, e.g., neurons and glia. Given the microstructural sensitivity of diffusion-encoding filters, investigation of metabolite diffusion properties using DW-MRS can thus provide exclusive cell and compartment-specific information. Furthermore, since many models and assumptions are used for quantification of water diffusion, metabolite diffusion may serve to generate a-priori information for model selection in DW-MRI. However, DW-MRS measurements are extremely challenging, from the acquisition to the accurate and correct analysis and quantification stages. In this review, we survey the state-of-the-art methods that have been developed for the robust acquisition, quantification and analysis of DW-MRS data and discuss the potential relevance of DW-MRS for elucidating brain microstructure in vivo. The review highlights that when accurate data on the diffusion of multiple metabolites is combined with accurate computational and geometrical modeling, DW-MRS can provide unique cell-specific information on the intracellular structure of brain tissue, in health and disease, which could serve as incentives for further application in vivo in human research and clinical MRI.

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Section: Multivoxel Dw-mrs and Dw-mrsimentioning

confidence: 99%

Insights into brain microstructure from in vivo DW-MRS

et al. 2018

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“…Another method that was originally proposed for the combination of spectra from a phase‐array coil, based on the singular value decomposition method, can also be used for this purpose . For diffusion‐weighted spectroscopic imaging, an additional navigator echo is needed to facilitate the phase realignment .…”

Section: Technical Considerations Of Diffusion Mrs Experimentsmentioning

confidence: 99%

“…A number of recent studies have employed diffusion MRS to characterize the macroscopic isotropic diffusion of metabolites in normal brains (25)(26)(27)(28). To probe the microstructure of neuronal cells effectively, a broad range of b-values and diffusion times are often used (15)(16)(17)(18)27,28).…”

Section: Diffusion Mrs Studies In Brainsmentioning

confidence: 99%

“…More recently, the diffusion spectroscopic imaging approach with a nominal voxel size of 6 × 6 × 8 mm 3 has been successfully demonstrated in mapping metabolite diffusion properties in human brains (26). Briefly, voxel-wise negative correlation of NAA and Cr ADCs with grey matter fraction was found, whereas no correlation between Cho ADC and grey matter fraction was observed (26). These findings illustrate the differences in metabolite diffusion behaviors in grey and white matter, probably caused by their difference in molecular crowding effects and organelle densities.…”

Section: Diffusion Mrs In Normal Brainsmentioning

confidence: 99%

“…Another method that was originally proposed for the combination of spectra from a phase-array coil, based on the singular value decomposition method, can also be used for this purpose (109). For diffusionweighted spectroscopic imaging, an additional navigator echo is needed to facilitate the phase realignment (26). The spectral quantification is usually performed using fitting algorithms that incorporate prior knowledge, such as frequency, phase, and amplitude ratios, into the model of spectral components.…”

Section: Spectral Processing and Adc Quantitationmentioning

confidence: 99%

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In vivo diffusion MRS investigation of non‐water molecules in biological tissues

Cao¹,

2016

NMR in Biomedicine

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Diffusion MRS of non-water molecules offers great potential in directly revealing various tissue microstructures and physiology at both cellular and subcellular levels. In brain, H diffusion MRS has been demonstrated as a new tool for probing normal tissue microstructures and their pathological changes. In skeletal muscle, H diffusion MRS could characterize slow and restricted intramyocellular lipid diffusion, providing a sensitive marker for metabolic alterations, while P diffusion MRS can measure ATP and PCr diffusion, which may reflect the capacity of cellular energy transport, complementing the information from frequently used P MRS in muscle. In intervertebral disk, H diffusion MRS can directly monitor extracellular matrix integrity by quantifying the mobility of macromolecules such as proteoglycans and collagens. In tumor tissue, C diffusion MRS could probe intracellular glycolytic metabolism, while H diffusion MRS may separate the spectrally overlapped lactate and lipid resonances. In this review, recent diffusion MRS studies of these biologically relevant non-water molecules under normal and diseased conditions will be presented. Technical considerations for diffusion MRS experiments will be discussed. With advances in MRI hardware and diffusion methodology, diffusion MRS of non-water molecules is expected to provide increasingly valuable and biologically specific information on tissue microstructures and physiology, complementing the traditional diffusion MRI of small and ubiquitous water molecules. Copyright © 2016 John Wiley& Sons, Ltd.

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