Diffusion tensor MRI of the corpus callosum and cognitive function in adults born preterm

Kontis, Dimitrios; Catani, Marco; Cuddy, Marion; Walshe, Muriel; Nosarti, Chiara; Jones, Derek K.; Wyatt, John; Rifkin, Larry; Murray, Robin M.; Allin, Matthew

doi:10.1097/wnr.0b013e328325a8f9

Cited by 76 publications

(73 citation statements)

References 22 publications

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“…In a quantitative study of VLBW adolescents, including DTI, 35 a lower fractional anisotropy was detected in posterior aspects of CC. These findings have, however, been challenged in a recent DTI study 36 that demonstrated a higher MD in the genu of the CC and a significant association between the MD and IQ in prematurely-born females at age 18 years. No changes were seen in the splenium in this study nor in any parts of male CCs.…”

Section: Discussionmentioning

confidence: 72%

Selectively Reduced Posterior Corpus Callosum Size in a Population-Based Sample of Young Adults Born with Low Birth Weight

Aukland

Westerhausen²,

Plessen³

et al. 2011

AJNR Am J Neuroradiol

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Section: Discussionmentioning

confidence: 72%

Selectively Reduced Posterior Corpus Callosum Size in a Population-Based Sample of Young Adults Born with Low Birth Weight

Aukland

Westerhausen²,

Plessen³

et al. 2011

AJNR Am J Neuroradiol

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“…This finding matches the association reported between increased mean diffusivity in the splenium of the corpus callosum with a low performance intelligence quotient in adults born preterm. 22 Notably, we also observed decreased FA in the association fibers of the superior longitudinal fasciculus in children having decreased performance on any of the 3 subscales, suggesting that abnormalities in these regions presage subsequent global developmental impairment.…”

Section: Discussionmentioning

confidence: 72%

White Matter Injury and General Movements in High-Risk Preterm Infants

Peyton¹,

Yang

Msall

et al. 2016

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Very preterm infants (birth weight, Ͻ1500 g) are at increased risk of cognitive and motor impairment, including cerebral palsy. These adverse neurodevelopmental outcomes are associated with white matter abnormalities on MR imaging at term-equivalent age. Cerebral palsy has been predicted by analysis of spontaneous movements in the infant termed "General Movement Assessment." The goal of this study was to determine the utility of General Movement Assessment in predicting adverse cognitive, language, and motor outcomes in very preterm infants and to identify brain imaging markers associated with both adverse outcomes and aberrant general movements.

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“…Widespread differences in white matter development have been frequently described in very preterm children throughout childhood and adolescence (14)(15)(16)(17). In general, white matter development comprises a cascade of events including the development of preoligodendrocytes, axons, and subplate neurons, which may be negatively affected in preterm children by multiple factors with accompanying excitotoxicity and ischemic events (18).…”

Section: Discussionmentioning

confidence: 99%

A crucial role for white matter alterations in interference control problems of very preterm children

et al. 2014

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Background: Attention problems are among the most prominent behavioral deficits reported in very preterm children (below 32 wk of gestation) at school age. In this study, we aimed to elucidate the brain abnormalities underlying attention problems in very preterm children by investigating the role of abnormalities in white and gray brain matter during interference control, using functional magnetic resonance imaging (fMRI)-guided probabilistic diffusion tensor tractography. Methods: Twenty-nine very preterm children (mean (SD) age: 8.6 (0.3) y), and 47 term controls (mean (SD) age: 8.7 (0.5) y), performed a fMRI version of the Eriksen Flanker task measuring interference control. results: Very preterm children showed slower reaction times than term controls when interfering stimuli were presented, indicating poorer interference control. Very preterm children and term controls did not differ in mean activation of the cortical regions involved in interference control. However, impaired fractional anisotropy (FA) was found in very preterm children in specifically those fiber tracts that innervate the cortical regions involved in interference control. Lower FA was related to poorer interference control in very preterm children. conclusion: White matter alterations have a crucial role in the interference control problems of very preterm children at school age. i mproved perinatal care has increased survival rates of very preterm (<32 wk of gestation) infants. However, large alterations in brain development remain present throughout childhood and adolescence (1), and surviving very preterm children appear to have pervasive behavioral problems more frequently than term peers (2,3). At school age, attention problems are among the most prominent behavioral deficits in very preterm children (4,5), having a detrimental impact on school performance and social functioning.One core aspect of attention is interference control, the ability to suppress distracters that might slow the primary response (6). The brain attention network involved in interference control has been widely investigated using functional magnetic resonance imaging (fMRI) tasks including the Eriksen Flanker task (7-9), suggesting involvement of the dorsal anterior cingulate cortex (dACC), inferior and lateral prefrontal cortices, and inferior parietal cortices.This study aims to elucidate brain abnormalities underpinning attention problems in very preterm children, by investigating the role of impairments in white and gray brain matter in interference control in very preterm children and term controls. First, we examined interference control problems and potential differences in cortical activation between very preterm children and term controls using the Eriksen Flanker task adapted for fMRI. Second, by using fMRI-guided probabilistic diffusion tensor tractography, we studied potential differences between very preterm children and term controls in white matter development using values of fractional anisotropy (FA) of specifically those fiber tracts that inne...

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Diffusion tensor MRI of the corpus callosum and cognitive function in adults born preterm

Cited by 76 publications

References 22 publications

Selectively Reduced Posterior Corpus Callosum Size in a Population-Based Sample of Young Adults Born with Low Birth Weight

Selectively Reduced Posterior Corpus Callosum Size in a Population-Based Sample of Young Adults Born with Low Birth Weight

White Matter Injury and General Movements in High-Risk Preterm Infants

A crucial role for white matter alterations in interference control problems of very preterm children

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