Diffusion tensor MRI of chemotherapy-induced cognitive impairment in non-CNS cancer patients: a review

Deprez, Sabine; Billiet, Thibo; Sunaert, Stefan; Leemans, Alexander

doi:10.1007/s11682-012-9220-1

Cited by 88 publications

(74 citation statements)

References 232 publications

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“…A recent cross-sectional investigation provided evidence for hippocampal damage that was related to decreased verbal memory performance [29]. In line with the findings from the animal work reported above, diffusion tensor imaging (DTI) studies have found chemotherapy-related reductions of white matter integrity that correlated with cognitive performance [30]. A prospective DTI study Paradigms included verbal long-term memory [37,38], verbal working memory [39,40], and tasks requiring rule testing or planning, both involving prefrontal cortex [41,42].…”

Section: Manymentioning

confidence: 75%

Challenges in research on the neural basis of „chemobrain”

Kaiser

Dietrich

2014

Translational Neuroscience

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Cancer survivors treated with chemotherapy frequently complain about impairment of cognitive functions including attention and memory. While the contribution of factors like psychological distress, anxiety or fatigue to this "chemobrain" syndrome has been discussed, studies in rodents have demonstrated the toxicity of various chemotherapeutic substances to the adult central nervous system. In humans, structural brain imaging has revealed both reduced gray and white matter volume and decreased white matter integrity related to chemotherapeutic treatment. Studies of brain function have found alterations in brain activation patterns during different types of tasks. Nevertheless, further clinical research using prospective designs in larger samples is required to better understand the relationship between chemotherapy and cognitive deficits. Variables that need to be considered more systematically include drug dose, genetic variations, and psychological factors. Assessing both electroencephalographic and hemodynamic responses during tasks at different stages of the processing hierarchy and at di erent di culty levels should help in pinpointing the cortical processes a ected by chemotherapy.

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Section: Manymentioning

confidence: 75%

Challenges in research on the neural basis of „chemobrain”

Kaiser

Dietrich

2014

Translational Neuroscience

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“…Recent studies have documented that chemotherapy can disrupt hippocampal neurogenesis (Dietrich et al 2006), and is associated with alterations in white matter integrity (Inagaki et al 2007; Deprez et al 2013). Recent rodent studies have shown that cisplatin inhibits neurogenesis and disrupts cognitive function (Manohar et al 2014; Vichaya et al 2015), and that metformin may prevent cisplatin-related central neurotoxicity (Zhou et al 2016).…”

Section: Discussionmentioning

confidence: 99%

Brain structure and function in patients with ovarian cancer treated with first-line chemotherapy: a pilot study

Correa

Root

Kryza‐Lacombe

et al. 2016

Brain Imaging and Behavior

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Background Women with ovarian cancer often undergo chemotherapy involving multiple agents. However, little is known about treatment-related central neurotoxicity in this population. The goal of this cross-sectional study was to assess brain structure and function and neurocognitive abilities in patients with ovarian cancer following first-line chemotherapy. Methods Eighteen patients with ovarian, peritoneal and fallopian tube cancer and eighteen healthy controls matched for gender, age and education participated in the study. The patients were evaluated 1–4 months following completion of first-line taxane/platinum chemotherapy. All participants underwent structural and functional magnetic resonance imaging (MRI), and completed neuropsychological tests of attention, memory and executive functions. Neuroimaging assessments included voxel-based morphometry (VBM) for measuring gray matter (GM) volume, and functional MRI (fMRI) during the N-back working memory task. Results The results of VBM showed that patients had significantly reduced GM volume compared to healthy controls in the right middle/superior frontal gyrus, and in the left supramarginal gyrus and left inferior parietal lobule. fMRI results indicated significantly decreased activation in patients relative to healthy controls in the left middle frontal gyrus and left inferior parietal lobule during the N-back task (1/2/3-back > 0-back). There were no statistically significant differences between the two groups on the neuropsychological tests. Conclusions This is the first study showing structural and functional alterations involving frontal and parietal regions in patients with ovarian cancer treated with first-line chemotherapy. These findings are congruent with studies involving women with breast cancer, and provide additional supporting evidence for central neurotoxicity associated with taxane/platinum chemotherapy.

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“…DTI measurements show strong correspondence with post-mortem dissection (Lawes, et al, 2008) however; DTI should be considered only a very indirect assessment of white matter organization (Jones, et al, 2013). Despite its limitations, DTI-based measures have been shown to be sensitive to various brain pathologies, including breast cancer-related cognitive impairment (Deprez, et al, 2013). …”

Section: Introductionmentioning

confidence: 99%

Brain network alterations and vulnerability to simulated neurodegeneration in breast cancer

Kesler¹,

Watson²,

Blayney³

2015

Neurobiology of Aging

107

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Breast cancer and its treatments are associated with mild cognitive impairment and brain changes that could indicate an altered or accelerated brain aging process. We applied diffusion tensor imaging (DTI) and graph theory to measure white matter organization and connectivity in 34 breast cancer survivors compared to 36 matched healthy female controls. We also investigated how brain networks (connectomes) in each group responded to simulated neurodegeneration based on network attack analysis. Compared to controls, the breast cancer group demonstrated significantly lower fractional anisotropy (FA), altered small-world connectome properties, lower brain network tolerance to systematic region (node) and connection (edge) attacks and significant cognitive impairment. Lower tolerance to network attack was associated with cognitive impairment in the breast cancer group. These findings provide further evidence of diffuse white matter pathology following breast cancer and extend the literature in this area with unique data demonstrating increased vulnerability of the post-breast cancer brain network to future neurodegenerative processes.

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Diffusion tensor MRI of chemotherapy-induced cognitive impairment in non-CNS cancer patients: a review

Cited by 88 publications

References 232 publications

Challenges in research on the neural basis of „chemobrain”

Challenges in research on the neural basis of „chemobrain”

Brain structure and function in patients with ovarian cancer treated with first-line chemotherapy: a pilot study

Brain network alterations and vulnerability to simulated neurodegeneration in breast cancer

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