Diffusion Tensor Magnetic Resonance Imaging of Prostate Cancer

Manenti, Guglielmo; Carlani, M.; Mancino, Stefano; Colangelo, Vittorio; Roma, Mauro Di; Squillaci, Ettore; Simonetti, Giovanni

doi:10.1097/01.rli.0000264059.46444.bf

Cited by 97 publications

(78 citation statements)

References 43 publications

(41 reference statements)

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“…With the recent introduction of ultra-fast echo-planar sequences and parallel imaging techniques, DTI could be applied to the prostate [7][8][9][10][11][12]. Several studies have reported the results of DTI in a healthy prostate or prostate cancer at 1.5 T [9,11,12].…”

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confidence: 99%

“…3 T MR scanners have several benefits over 1.5 T MR scanners, such as a twofold increase in SNR, resulting in improved spatial and temporal resolution [13]. However, few studies have investigated the prostate DTI at 3 T [7,8,10].The possible applications of DTI in prostate tissue investigated so far [7][8][9][10][11][12] have focused on differentiating between benign prostate tissue and cancer and determining normative FA and ADC values in the prostate. No studies for optimising DTI parameters such as number of diffusion-encoding directions in the prostate have been published, and there is no consensus for optimal diffusion-encoding directions in prostate DTI.…”

mentioning

confidence: 99%

“…The prostate consists of histologically different components-glandular and fibromuscular elements. A few studies reported the potential of prostate tractography in evaluating the microstructural organisation of the prostate [7,8], but the role of tractography in the prostate has not been yet determined.With the recent introduction of ultra-fast echo-planar sequences and parallel imaging techniques, DTI could be applied to the prostate [7][8][9][10][11][12]. Several studies have reported the results of DTI in a healthy prostate or prostate cancer at 1.5 T [9,11,12].…”

mentioning

confidence: 99%

“…However, 1.5 T MR scanners have major limitations, such as poor signal-to-noise ratio (SNR), which may affect the accuracy of measuring the apparent diffusion coefficient (ADC) or fractional anisotropy (FA) values. More recently, 3 T MR scanners have been introduced into clinical practice and DTI at 3 T has been a feasible tool in the prostate [7,8,10]. 3 T MR scanners have several benefits over 1.5 T MR scanners, such as a twofold increase in SNR, resulting in improved spatial and temporal resolution [13].…”

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Diffusion tensor imaging of normal prostate at 3 T: effect of number of diffusion-encoding directions on quantitation and image quality

Kim

Park²

2012

BJR

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Objective: The purpose of this study was to prospectively investigate differences of diffusion tensor imaging (DTI) using a different number of diffusion-encoding directions and to evaluate the feasibility of tractography in healthy prostate at 3 T. Method: 12 healthy volunteers underwent DTI with single-shot echo-planar imaging at 3 T using a phased-array coil. Diffusion gradients of each DTI were applied in 6 (Group 1), 15 (Group 2) and 32 (Group 3) non-collinear directions. For each group, the mean apparent diffusion coefficient (ADC), fractional anisotrophy (FA) and signal-tonoise ratio (SNR) were measured in the peripheral zone (PZ) and central gland (CG). The quality of diffusion-weighted and tractographic images were also evaluated. Results: In all three groups, the mean ADC value of the CG was statistically lower than that of the PZ (p,0.01) and the mean FA value of the CG was statistically greater than that of the PZ (p,0.01). For the mean FA value of the CG, no statistical difference was seen among the three groups (p50.052). However, the mean FA value of the PZ showed a statistical difference among the three groups (p50.035). No significant difference in SNR values was seen among the three groups (p.0.05). Imaging quality of diffusionweighted tractographic images was rated as satisfactory or better in all three groups and was similar among the three groups. Conclusion: In conclusion, prostate DTI at 3 T was feasible with different numbers of diffusion-encoding directions. The number of diffusion-encoding directions did not have a significant effect on imaging quality. Diffusion tensor imaging (DTI) is a common noninvasive method of assessing the anisotropy and organisation of structures in neurological and musculoskeletal imaging [1][2][3][4]. Generally, water diffusion in tissues without a well-organised microstructure shows isotropic direction whereas that in structures with a high degree of structural order has a preferential direction or anisotropy [5,6]. The prostate consists of histologically different components-glandular and fibromuscular elements. A few studies reported the potential of prostate tractography in evaluating the microstructural organisation of the prostate [7,8], but the role of tractography in the prostate has not been yet determined.With the recent introduction of ultra-fast echo-planar sequences and parallel imaging techniques, DTI could be applied to the prostate [7][8][9][10][11][12]. Several studies have reported the results of DTI in a healthy prostate or prostate cancer at 1.5 T [9,11,12]. However, 1.5 T MR scanners have major limitations, such as poor signal-to-noise ratio (SNR), which may affect the accuracy of measuring the apparent diffusion coefficient (ADC) or fractional anisotropy (FA) values. More recently, 3 T MR scanners have been introduced into clinical practice and DTI at 3 T has been a feasible tool in the prostate [7,8,10]. 3 T MR scanners have several benefits over 1.5 T MR scanners, such as a twofold increase in SNR, resulting in improved spatial and tem...

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Diffusion tensor imaging of normal prostate at 3 T: effect of number of diffusion-encoding directions on quantitation and image quality

Kim

Park²

2012

BJR

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“…Preliminary studies of diffusion tensor imaging (DTI) in the prostate have been reported (21)(22)(23)(24). Sinha and Sinha demonstrated the feasibility of in vivo prostate DTI and found the diffusion ellipsoid in prostate tissue was anisotropic and mostly in the superior-inferior direction (23).…”

Section: Diffusion Tensor Imagingmentioning

confidence: 99%

MRI of the prostate: Clinical relevance and emerging applications

Mazaheri

Shukla–Dave

Muellner

et al. 2011

Magnetic Resonance Imaging

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MRI of the prostate can aid in many aspects of prostate cancer management, from initial detection to treatment planning and follow-up. This review describes the current strengths and limitations of conventional anatomic and molecular MR imaging techniques (including MR spectroscopic imaging and dynamic contrast-enhanced imaging) for aiding prostate cancer management. It also describes promising emerging approaches for acquiring, analyzing, and applying MR imaging data, and the major research and educational efforts that will be required to realize the potential of prostate MR imaging in routine clinical practice.

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Diffusion tensor MRI: Preliminary anisotropy measures and mapping of breast tumors

Partridge¹,

Ziadloo²,

Murthy³

et al. 2010

Magnetic Resonance Imaging

111

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Purpose: To investigate whether diffusion tensor imaging (DTI) measures of anisotropy in breast tumors are different from normal breast tissue and can improve the discrimination between benign and malignant lesions. Materials and Methods:The study included 81 women with 105 breast lesions (76 malignant, 29 benign). DTI was performed during breast MRI examinations, and fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values were measured for breast lesions and normal tissue in each subject. FA and ADC were compared between cancers, benign lesions, and normal tissue by univariate and multivariate analyses.Results: The FA of carcinomas (mean 6 SD: 0.24 6 0.07) was significantly lower than normal breast tissue in the same subjects (0.29 6 0.07; P < 0.0001). Multiple logistic regression showed that FA and ADC were each independent discriminators of malignancy (P < 0.0001), and that FA improved discrimination between cancer and normal tissue over ADC alone. However, there was no difference in FA between malignant and benign lesions (P ¼ 0.98).Conclusion: Diffusion anisotropy is significantly lower in breast cancers than normal tissue, which may reflect alterations in tissue organization. Our preliminary results suggest that FA adds incremental value over ADC alone for discriminating malignant from normal tissue but does not help with distinguishing benign from malignant lesions.

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Diffusion Tensor Magnetic Resonance Imaging of Prostate Cancer

Abstract: Three Tesla DTI of the prostate gland is feasible and has the potential for providing improved diagnostic information.

Cited by 97 publications

References 43 publications

Diffusion tensor imaging of normal prostate at 3 T: effect of number of diffusion-encoding directions on quantitation and image quality

Diffusion tensor imaging of normal prostate at 3 T: effect of number of diffusion-encoding directions on quantitation and image quality

MRI of the prostate: Clinical relevance and emerging applications

Diffusion tensor MRI: Preliminary anisotropy measures and mapping of breast tumors

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