Diffusion tensor imaging tractography study in bipolar disorder patients compared to first‐degree relatives and healthy controls

Mahapatra, Ananya; Khandelwal, Shubham; Sharan, Pratap; Garg, Ajay; Mishra, Nidhi

doi:10.1111/pcn.12530

Cited by 21 publications

(19 citation statements)

References 57 publications

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“…Reduced FA in the body of the CC could not be attributed to other clinical variables, which supports the idea that abnormal WM microstructure in the CC might be a trait marker of BD. Indeed, reduced FA in the CC has emerged as the most robust finding in several meta‐analyses in individuals with BD and has also been reported repeatedly in unaffected REL during late adolescence and adulthood . The cluster we identified in REL was located in the body of the CC known to interconnect parietal and temporal cortices.…”

Section: Discussionsupporting

confidence: 59%

“…Indeed, reduced FA in the CC has emerged as the most robust finding in several meta-analyses in individuals with BD 11,12 and has also been reported repeatedly in unaffected REL during late adolescence 15 and adulthood. 16 The cluster we identified in REL was located in the body of the CC known to interconnect parietal and temporal cortices. The body of the CC develops into the corona radiata, which has been associated with processing speed and working memory performance.…”

Section: Hypothesis 1 Alterations In Wm Microstructure a Trait Markermentioning

confidence: 90%

“…Moreover, seven studies in unaffected adult REL reported reduced FA in the CC, 15 cingulum bundle, 16 SLF, 16,17 ATR, 15,17 and UNC. [15][16][17] Based on these findings, it has been argued that altered WM microstructure might represent a quantitative risk marker for BD, meaning it plays an antecedent, possibly causal, role in the pathophysiology of BD. 13 However, the two studies that compared adolescent REL (n = 25-79, age: 15-21) to HV's yielded conflicting results.…”

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confidence: 99%

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White matter microstructure in youth with and at risk for bipolar disorder

et al. 2020

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Objectives Bipolar disorder (BD) and familial risk for BD have been associated with aberrant white matter (WM) microstructure in the corpus callosum and fronto‐limbic pathways. These abnormalities might constitute trait or state marker and have been suggested to result from aberrant maturation and to relate to difficulties in emotion regulation. Methods To determine whether WM alterations represent a trait, disease or resilience marker, we compared youth at risk for BD (n = 36 first‐degree relatives, REL) to youth with BD (n = 36) and healthy volunteers (n = 36, HV) using diffusion tensor imaging. Results Individuals with BD and REL did not differ from each other in WM microstructure and, compared to HV, showed similar aberrations in the superior corona radiata (SCR)/corticospinal tract (CST) and the body of the corpus callosum. WM microstructure of the anterior CC showed reduced age‐related in‐creases in BD compared to REL and HV. Further, individuals with BD and REL showed in‐creased difficulties in emotion regulation, which were associated with the microstructure of the anterior thalamic radiation. Discussion Alterations in the SCR/CST and the body of the corpus callosum appear to represent a trait marker of BD, whereas changes in other WM tracts seem to be a disease state marker. Our findings also support the role of aberrant developmental trajectories of WM microstructure in the risk architecture of BD, although longitudinal studies are needed to confirm this association. Finally, our findings show the relevance of WM microstructure for difficulties in emotion regulation—a core characteristic of BD.

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Section: Discussionsupporting

confidence: 59%

Section: Hypothesis 1 Alterations In Wm Microstructure a Trait Markermentioning

confidence: 90%

mentioning

confidence: 99%

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White matter microstructure in youth with and at risk for bipolar disorder

et al. 2020

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“…6,7 In studies of patients with BD, however, various regions showing both FA increases and decreases have been reported: for example in the prefrontal white matter, temporal white matter and cingulum bundle. [8][9][10] Performing a metaanalysis is a powerful way to integrate the results from many studies in an unbiased way. 11 Therefore, using voxel-based meta-analysis to detect common abnormalities in patients with BD from multiple original studies is of particular importance.…”

Section: Introductionmentioning

confidence: 99%

Psychoradiologic abnormalities of white matter in patients with bipolar disorder: diffusion tensor imaging studies using tract-based spatial statistics

Yang

Luo

et al. 2019

jpn

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Background: An increasing number of psychoradiology studies that use tract-based spatial statistics (TBSS) of diffusion tensor imaging have reported abnormalities of white matter in patients with bipolar disorder; however, robust conclusions have proven elusive, especially considering some important clinical and demographic factors. In the present study, we performed a quantitative meta-analysis of TBSS studies to elucidate the most consistent white-matter abnormalities in patients with bipolar disorder. Methods: We conducted a systematic search up to May 2017 for all TBSS studies comparing fractional anisotropy (FA) between patients with bipolar disorder and healthy controls. We performed anisotropic effect size-signed differential mapping meta-analysis. Results: We identified a total of 22 data sets including 556 patients with bipolar disorder and 623 healthy controls. We found significant FA reductions in the genu and body of the corpus callosum in patients with bipolar disorder relative to healthy controls. No regions of increased FA were reported. In subgroup analyses, the FA reduction in the genu of the corpus callosum retained significance in patients with bipolar disorder type I, and the FA reduction in the body of the corpus callosum retained significance in euthymic patients with bipolar disorder. Meta-regression analysis revealed that the percentage of female patients was negatively correlated with reduced FA in the body of the corpus callosum. Limitations: Data acquisition, patient characteristics and clinical variables in the included studies were heterogeneous. The small number of diffusion tensor imaging studies using TBSS in patients with bipolar disorder type II, as well as the lack of other clinical information, hindered the application of subgroup meta-analyses. Conclusion: Our study consistently identified decreased FA in the genu and body of the corpus callosum, suggesting that interhemispheric communication may be the connectivity most affected in patients with bipolar disorder.

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“…Findings also include tractography studies being more accurate than VBA and TBSS studies in terms of tract specificity. For instance ( Mahapatra et al, 2017 ) reported reduced FA in remitted BD in comparison to healthy controls (HC) and healthy relatives in the CC. ( Toteja et al, 2015 ) demonstrated lower FA and age-associated increases of mean diffusivity in the genu and the splenium of the CC, whilst ( Sarrazin et al, 2014 ) found reduced FA in the body and the splenium of the CC.…”

Section: Introductionmentioning

confidence: 99%

Physical activity is associated with left corticospinal tract microstructure in bipolar depression

Bracht

Steinau

Federspiel

et al. 2018

NeuroImage: Clinical

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Psychomotor retardation and reduced daily activities are core features of the depressive syndrome including bipolar disorder (BD). It was the aim of this study to investigate white matter microstructure of the motor system in BD during depression and its association with motor activity. We hypothesized reduced physical activity, microstructural alterations of motor tracts and different associations between activity levels and motor tract microstructure in BD. Nineteen bipolar patients with a current depressive episode (BD) and 19 healthy controls (HC) underwent diffusion weighted magnetic resonance imaging (DW-MRI)-scans. Quantitative motor activity was assessed with 24 h actigraphy recordings. Bilateral corticospinal tracts (CST), interhemispheric connections between the primary motor cortices (M1) and between the pre-supplementary motor areas (pre-SMA) were reconstructed individually based on anatomical landmarks using Diffusion Tensor Imaging (DTI) based tractography. Mean fractional anisotropy (FA) was sampled along the tracts. To enhance specificity of putative findings a segment of the optic radiation was reconstructed as comparison tract. Analyses were complemented with Tract Based Spatial Statistics (TBSS) analyses. BD had lower activity levels (AL). There was a sole increase of fractional anisotropy (FA) in BD in the left CST. Further, there was a significant group x AL interaction for FA of the left CST pointing to a selective positive association between FA and AL in BD. The comparison tract and TBSS analyses did not detect significant group differences. Our results point to white matter microstructure alterations of the left CST in BD. The positive association between motor activity and white matter microstructure suggests a compensatory role of the left CST for psychomotor retardation in BD.

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Diffusion tensor imaging tractography study in bipolar disorder patients compared to first‐degree relatives and healthy controls

Abstract: These findings suggest that BD patients and their FDR show alterations in microstructural integrity of white matter tracts, compared to the healthy population.

Cited by 21 publications

References 57 publications

White matter microstructure in youth with and at risk for bipolar disorder

White matter microstructure in youth with and at risk for bipolar disorder

Psychoradiologic abnormalities of white matter in patients with bipolar disorder: diffusion tensor imaging studies using tract-based spatial statistics

Physical activity is associated with left corticospinal tract microstructure in bipolar depression

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