Diffusion Tensor Imaging: Structural Connectivity Insights, Limitations and Future Directions

Lanyon, Linda

doi:10.5772/23245

Cited by 4 publications

(1 citation statement)

References 115 publications

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“…Currently, diffusion tensor imaging (DTI) has been widely used as a noninvasive tool to investigate and measure the integrity of white matter in vivo [15]. Fractional anisotropy (FA), one of DTI parameters, can quantify the degree of water diffusion and reliably visualize the microstructural status, but it is susceptible to axonal myelination as well as density and orientational coherence [16].…”

Section: Introductionmentioning

confidence: 99%

Ipsilesional High Frequency Repetitive Transcranial Magnetic Stimulation Add-On Therapy Improved Diffusion Parameters of Stroke Patients with Motor Dysfunction: A Preliminary DTI Study

et al. 2016

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Purpose. The aim of this study was to evaluate the effects of high frequency repetitive transcranial magnetic stimulation (HF-rTMS) on stroke patients with motor dysfunction and to investigate the underlying neural mechanism. Methods. Fifteen stroke patients were assigned to the rTMS treatment (RT) group and conventional treatment (CT) group. Patients in the RT received 10 Hz rTMS stimulation on the ipsilesional primary motor cortex for 10 days plus conventional treatment of CT, which consisted of acupuncture and antiplatelet aggregation medication. Difference in fractional anisotropy (FA) between pretreatment and posttreatment and between two groups was determined. Correlations between FA values and neurological assessments were also calculated. Results. Both groups significantly improved the neurological function after treatment. rTMS-treated patients showed better improvement in Fugl-Meyer Assessment (FMA) score and increased FA value in motor-related white matter and gray matter cortices compared with CT-treated patients and pretreatment status. Besides, the increased FA value in the ipsilesional posterior limb of the internal capsule in RT group was significantly correlated with the improved FMA score. Significance. HF-rTMS could be a supplement therapy to CT in improving motor recovery in patients with stroke. And this benefit effect may be achieved through modulating the ipsilesional corticospinal tracts and motor-related gray matter cortices.

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Section: Introductionmentioning

confidence: 99%

Ipsilesional High Frequency Repetitive Transcranial Magnetic Stimulation Add-On Therapy Improved Diffusion Parameters of Stroke Patients with Motor Dysfunction: A Preliminary DTI Study

et al. 2016

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IRM fonctionnelle cérébrale : les principes

Andréelli

Mosbah

2014

Médecine des Maladies Métaboliques

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New transmission condition accounting for diffusion anisotropy in thin layers applied to diffusion MRI

Caubet

Haddar

et al. 2017

ESAIM: M2AN

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Abstract. The Bloch−Torrey Partial Differential Equation (PDE) can be used to model the diffusion Magnetic Resonance Imaging (dMRI) signal in biological tissue. In this paper, we derive an Anisotropic Diffusion Transmission Condition (ADTC) for the Bloch−Torrey PDE that accounts for anisotropic diffusion inside thin layers. Such diffusion occurs, for example, in the myelin sheath surrounding the axons of neurons. This ADTC can be interpreted as an asymptotic model of order two with respect to the layer thickness and accounts for water diffusion in the normal direction that is low compared to the tangential direction. We prove uniform stability of the asymptotic model with respect to the layer thickness and a mass conservation property. We also prove the theoretical quadratic accuracy of the ADTC. Finally, numerical tests validate these results and show that our model gives a better approximation of the dMRI signal than a simple transmission condition that assumes isotropic diffusion in the layers.Mathematics Subject Classification. 35C20, 35Q92.

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Diffusion Tensor Imaging: Structural Connectivity Insights, Limitations and Future Directions

Cited by 4 publications

References 115 publications

Ipsilesional High Frequency Repetitive Transcranial Magnetic Stimulation Add-On Therapy Improved Diffusion Parameters of Stroke Patients with Motor Dysfunction: A Preliminary DTI Study

Ipsilesional High Frequency Repetitive Transcranial Magnetic Stimulation Add-On Therapy Improved Diffusion Parameters of Stroke Patients with Motor Dysfunction: A Preliminary DTI Study

IRM fonctionnelle cérébrale : les principes

New transmission condition accounting for diffusion anisotropy in thin layers applied to diffusion MRI

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