Diffusion tensor imaging of the brain white matter microstructure in patients with chronic kidney disease and its correlation with cognition

Zhang, Chaoyang; Yu, Huan; Cai, Yan; Wu, Ning; Liang, Shouyun; Zhang, Chun; Duan, Zhi-Yu; Zhang, Zhou; Cai, Guangyan

doi:10.3389/fneur.2022.1086772

Cited by 4 publications

(1 citation statement)

References 19 publications

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“…22,23 Diffusion tensor imaging and diffusion kurtosis imaging found that patients with CKD showed cognitive impairment and changes in the brain white matter (WM) microstructure. 24,25 Previous studies mainly focused on neural activity and cerebral perfusion, but neurovascular coupling evidence from fMRI disregarded the relationship between neuronal activity and vascular injury.…”

Section: Introductionmentioning

confidence: 99%

Dysfunctional Coupling of Cerebral Blood Flow and Susceptibility Value in the Bilateral Hippocampus is Associated with Cognitive Decline in Nondialysis Patients with CKD

Liu

Song

Yang

et al. 2023

JASN

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Background: Cerebral blood flow (CBF) and susceptibility values reflect vascular and iron metabolism, providing mechanistic insights into conditions of health and disease. Non-dialysis patients with chronic kidney disease (CKD) show a cognitive decline, but the pathophysiological mechanisms underlying this remain unclear. Methods: Three-dimensional pseudo-continuous arterial spin labeling and quantitative susceptibility mapping were prospectively performed in 40 patients with stage 1–4 CKD (CKD 1–4), 47 non-dialysis patients with stage 5 CKD (CKD 5ND), and 44 healthy controls. Voxel-based global and regional analyses of CBF, susceptibility values, and vascular-susceptibility coupling were performed. Furthermore, the association between clinical performance and cerebral perfusion and iron deposition was analyzed. Results: For CBF, patients with CKD 5ND had higher normalized CBF in the hippocampus and thalamus than healthy controls. Patients with CKD 5ND had higher normalized CBF in the hippocampus and thalamus than those with CKD 1–4. The susceptibility values in the hippocampus and thalamus were lower in patients with CKD 5ND than in healthy controls. Patients with CKD 5ND had higher susceptibility value in the caudate nucleus than those with CKD 1–4. More importantly, patients with CKD 5ND had lower CBF-susceptibility coupling than healthy controls. Additionally, CBF and susceptibility values were significantly associated with clinical performance. Conclusions: Our findings demonstrate a new neuropathological mechanism in patients with CKD, which leads to regional changes in CBF-susceptibility coupling. These changes are related to cognitive decline, providing potential imaging markers for assessing clinical disability and cognitive decline in these patients.

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Section: Introductionmentioning

confidence: 99%

Dysfunctional Coupling of Cerebral Blood Flow and Susceptibility Value in the Bilateral Hippocampus is Associated with Cognitive Decline in Nondialysis Patients with CKD

Liu

Song

Yang

et al. 2023

JASN

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Comparison of brain gray matter volume changes in peritoneal dialysis and hemodialysis patients with chronic kidney disease: a VBM study

Xiao,

Zhou,

et al. 2024

Front. Neurosci.

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ObjectiveThis study aims to compare gray matter volume changes in patients with chronic kidney disease (CKD) undergoing peritoneal dialysis (PD) and hemodialysis (HD) using voxel-based morphometry (VBM).MethodsA total of 27 PD patients, 25 HD patients, and 42 healthy controls were included. VBM analysis was performed, and cognitive function was assessed using the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment Scale (MoCA). The correlation between cognitive function and changes in brain gray matter volume was analyzed.ResultsBoth peritoneal dialysis and hemodialysis patients had partial gray matter volume reduction compared to the controls, but the affected brain regions were not uniform. The hemodialysis patients had greater volume reduction in certain brain regions than the PD patients. The MMSE and MoCA scores were positively correlated with gray matter volume changes.ConclusionDifferent dialysis modalities cause damage to specific areas of the brain, which can be detected using VBM. VBM, combined with cognitive function assessment, can help detect structural brain changes and cognitive impairment in patients with different dialysis modalities. The comprehensive application of VBM in the field of neurological function deserves further exploration.

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The Relationship Between Sleep and Brain Function in Older Adults With Chronic Kidney Disease and Self-Identified Cognitive Impairment

Hannan¹,

Jeamjitvibool²,

Luo³

et al. 2023

J Gerontol Nurs

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Older adults with chronic kidney disease (CKD) are at risk for cognitive impairment and sleep disturbances. The purpose of the current study was to investigate the relationship between sleep and brain structure/function in older adults with CKD and self-identified cognitive impairment. The sample ( N = 37) had a mean age of 68 years ( SD = 4.9 years), estimated glomerular filtration rate of 43.7 mL/min/1.73m 2 ( SD = 10.98), median sleep time of 7.4 hours, and was 70% female. Sleeping <7.4 hours, compared to ≥7.4 hours, was associated with better attention/information processing (β = 11.46, 95% confidence interval [CI] [3.85, 19.06]) and better learning/memory (β = 2.06, 95% CI [0.37, 3.75]). Better sleep efficiency was associated with better global cerebral blood flow (β = 3.30, 95% CI [0.65, 5.95]). Longer awake length after sleep onset was associated with worse fractional anisotropy of the cingulum (β = −0.01, 95% CI [−0.02, −0.003]). Sleep duration and continuity may be related to brain function in older adults with CKD and self-identified cognitive impairment. [ Journal of Gerontological Nursing, 49 (7), 31–39.]

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Diffusion tensor imaging of the brain white matter microstructure in patients with chronic kidney disease and its correlation with cognition

Cited by 4 publications

References 19 publications

Dysfunctional Coupling of Cerebral Blood Flow and Susceptibility Value in the Bilateral Hippocampus is Associated with Cognitive Decline in Nondialysis Patients with CKD

Dysfunctional Coupling of Cerebral Blood Flow and Susceptibility Value in the Bilateral Hippocampus is Associated with Cognitive Decline in Nondialysis Patients with CKD

Comparison of brain gray matter volume changes in peritoneal dialysis and hemodialysis patients with chronic kidney disease: a VBM study

The Relationship Between Sleep and Brain Function in Older Adults With Chronic Kidney Disease and Self-Identified Cognitive Impairment

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