Diffusion Tensor Imaging of the Superior Longitudinal Fasciculus and Working Memory in Recent-Onset Schizophrenia

Karlsgodt, Katherine H.; Erp, Theo G.M. van; Poldrack, Russell A.; Bearden, Carrie E.; Nuechterlein, Keith H.; Cannon, Tyrone D.

doi:10.1016/j.biopsych.2007.06.017

Cited by 311 publications

(238 citation statements)

References 38 publications

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“…We have linked DTI-derived measures of probabilistic connectivity with cortical physiology measured with fMRI and working memory performance, which is critically affected in the developmental pathophysiology of schizophrenia. Others have shown a relationship of FA and working memory performance in patients with schizophrenia (eg, Karlsgodt et al, 2008;Lim et al, 2006), and recent papers found correlations between working memory performance and anisotropy of the ALIC (Mamah et al, 2010) and of the left thalamus (Qiu et al, 2009) in schizophrenia, and mean diffusivity of the medial thalamus in healthy aging subjects (Charlton et al, 2010). Our findings also indicate that bulk thalamocortical connectivity is relevant to neurocognitive processes such as working memory.…”

Section: Discussionsupporting

confidence: 75%

Investigation of Anatomical Thalamo-Cortical Connectivity and fMRI Activation in Schizophrenia

Marenco

Stein

Savostyanova

et al. 2011

Neuropsychopharmacol

138

101

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The purpose of this study was to examine measures of anatomical connectivity between the thalamus and lateral prefrontal cortex (LPFC) in schizophrenia and to assess their functional implications. We measured thalamocortical connectivity with diffusion tensor imaging (DTI) and probabilistic tractography in 15 patients with schizophrenia and 22 age-and sex-matched controls. The relationship between thalamocortical connectivity and prefrontal cortical blood-oxygenation-level-dependent (BOLD) functional activity as well as behavioral performance during working memory was examined in a subsample of 9 patients and 18 controls. Compared with controls, schizophrenia patients showed reduced total connectivity of the thalamus to only one of six cortical regions, the LPFC. The size of the thalamic region with at least 25% of model fibers reaching the LPFC was also reduced in patients compared with controls. The total thalamocortical connectivity to the LPFC predicted working memory task performance and also correlated with LPFC BOLD activation. Notably, the correlation with BOLD activation was accentuated in patients as compared with controls in the ventral LPFC. These results suggest that thalamocortical connectivity to the LPFC is altered in schizophrenia with functional consequences on working memory processing in LPFC.

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Section: Discussionsupporting

confidence: 75%

Investigation of Anatomical Thalamo-Cortical Connectivity and fMRI Activation in Schizophrenia

Marenco

Stein

Savostyanova

et al. 2011

Neuropsychopharmacol

138

101

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“…This is in correspondence with the concept of reduced fronto-temporal connectivity (Kubicki et al, 2002;Shergill et al, 2002;Hubl et al, 2004;Frith et al, 2009;Vercammen et al, 2010). A number of other functional MRI studies also found evidence of reduced connectivity between these regions during different language processes, including talking, verbal learning, verbal fluency and word detection, supporting our finding (Karlsgodt et al, 2008;Jeong et al, 2009;Ford et al, 2010;Hashimoto et al, 2010). Functional changes may also be linked to reduced anatomical connectivity, as revealed by DTI studies measuring white matter integrity (Hubl et al, 2004;O'Daly et al, 2007;Li et al, 2010).…”

Section: Discussionsupporting

confidence: 92%

“…The fronto-temporal dysconnectivity idea is supported by electrophysiological studies showing reduced fronto-temporal connectivity during talking (Ford et al, 2010), and reduced synchrony during the prespeech phase (Ford et al, 2007) in people with schizophrenia, particularly in those with AVH. Diffusion tensor imaging (DTI) studies and functional magnetic resonance imaging (fMRI) studies also showed a decreased connectivity between lateral frontal and the temporal areas in people with schizophrenia (Hubl et al, 2004;O'Daly et al, 2007;Li et al, 2010), also related to verbal learning (Karlsgodt et al, 2008;Hashimoto et al, 2010), verbal fluency capacity (Jeong et al, 2009) and hallucinations (Lawrie et al, 2002). Finally, computer simulations, verified by patient studies, showed that fronto-temporal dysconnectivity may result in erroneous word detection and spontaneous word generation (Hoffman and McGlashan, 1998;Hoffman, 1999).…”

Section: Introductionmentioning

confidence: 99%

Abnormal connectivity between attentional, language and auditory networks in schizophrenia

Liemburg

Vercammen

Horst

et al. 2012

Schizophrenia Research

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“…Further, as with proactive cognitive control, there is evidence suggesting a key role for impaired connectivity between DLPFC and other WM related regions (e.g., parietal cortex, thalamus and striatum) in explaining WM impairments in schizophrenia (51)(52)(53)(54)(55), as well as evidence for altered gamma and theta oscillatory activity in prefrontal regions associated with WM impairments in this disorder (e.g., [56][57][58].…”

Section: Prefrontal Recruitment During Working Memory In Schizophreniamentioning

confidence: 99%

Cognitive impairments in psychotic disorders: common mechanisms and measurement

2014

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Decades of research have provided robust evidence of cognitive impairments in psychotic disorders. Individuals with schizophrenia appear to be impaired on the majority of neuropsychological tasks, leading some researchers to argue for a "generalized deficit", in which the multitude of cognitive impairments are the result of a common neurobiological source. One such common mechanism may be an inability to actively represent goal information in working memory as a means to guide behavior, with the associated neurobiological impairment being a disturbance in the function of the dorsolateral prefrontal cortex. Here, we provide a discussion of the evidence for such impairment in schizophrenia, and how it manifests in domains typically referred to as cognitive control, working memory and episodic memory. We also briefly discuss cognitive impairment in affective psychoses, reporting that the degree of impairment is worse in schizophrenia than in bipolar disorder and psychotic major depression, but the profile of impairment is similar, possibly reflecting common mechanisms at the neural level. Given the recent release of the DSM-5, we end with a brief discussion on assessing cognition in the context of diagnosis and treatment planning in psychotic disorders.

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Diffusion Tensor Imaging of the Superior Longitudinal Fasciculus and Working Memory in Recent-Onset Schizophrenia

Cited by 311 publications

References 38 publications

Investigation of Anatomical Thalamo-Cortical Connectivity and fMRI Activation in Schizophrenia

Investigation of Anatomical Thalamo-Cortical Connectivity and fMRI Activation in Schizophrenia

Abnormal connectivity between attentional, language and auditory networks in schizophrenia

Cognitive impairments in psychotic disorders: common mechanisms and measurement

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