“…Several studies have reported the infiltrative growth of glioblastoma multiforme (GBM) cells in apparently unaffected brain regions remote from the confirmed primary lesion [5,17,24,32] without correlating changes on computed tomographic or MR images [20,38]. Diffusion tensor imaging (DTI) [2,14,34] and localized proton MRS provided subtle hints towards remote infiltration of GBM cells [4,14,18]. This work investigated the use of DTI and corresponding metrics as putative indicators of the invasiveness of malignant brain tumors.…”