Diffusion Tensor Imaging in Patients With Adult Chronic Idiopathic Hydrocephalus

Hattingen, Elke; Jurcoane, Alina; Melber, Julia; Blasel, Stella; Zanella, Friedhelm E.; Neumann‐Haefelin, Tobias; Singer, Oliver C.

doi:10.1227/01.neu.0000367801.35654.ec

Cited by 91 publications

(108 citation statements)

References 26 publications

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“…10,26) Several previous studies have shown that INPH patients exhibit lower FA values in the frontal areas, including the forceps minor, than normal subjects. 6,27) In addition, our analyses revealed some association of lower FA values in these areas with the clinical symptoms of INPH (Table 3). Taken together, these findings suggest that neural degeneration in these areas could contribute to the essential pathology that causes INPH symptoms.…”

Section: Discussionmentioning

confidence: 59%

“…This finding conflicts with previous studies that reported higher FA values within the corticospinal tracts for INPH patients than for normal subjects. 6,22) Such changes were even reversible after shunt implantation. 22) This could mean that higher corticospinal tract FA values may be important to better characterize INPH white matter changes.…”

Section: Discussionmentioning

confidence: 99%

“…6,9,20,22,27) DTI can sensitively detect the direction of diffusion of water molecules and so reveals the orientation of the white matter tracts. 36) This anatomical detail enables clinically useful characterization of the degeneration of neural fibers affected by various neural diseases.…”

Section: Dti Of Inphmentioning

confidence: 99%

“…37) Recent studies based on fractional anisotropy (FA) values in some brain regions, including the corpus callosum and corticospinal tracts, have reported that patients with INPH exhibit white matter changes. 6,20,22,27) Quantitative analysis of FA values would be useful to better characterize the white matter changes in INPH patients. 6,20) The present study used a computer-automated technique for FA evaluation and showed that, compared with control subjects in a similar age range, FA values in the forceps minor (anterior portion of corpus callosum) were much lower in INPH patients and that low values were associated with more severe clinical manifestations.…”

Section: Dti Of Inphmentioning

confidence: 99%

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Diffusion Tensor Imaging of Idiopathic Normal Pressure Hydrocephalus: A Voxel-Based Fractional Anisotropy Study

Koyama

Marumoto

Domen

et al. 2012

Neurol. Med. Chir.(Tokyo)

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Diffusion tensor imaging (DTI) using a 3.0 tesla magnetic resonance scanner was used to investigate white matter changes caused by idiopathic normal pressure hydrocephalus (INPH) in 10 patients diagnosed by clinical symptoms (gait disturbance, dementia, and/or urinary incontinence) and Evans index À0.3, and compared with findings for 10 age-matched controls (AE60 years). Then, using a computer-automated method, fractional anisotropy (FA) brain maps were generated and finally transformed into the standard space. Voxel-based FA values within two regions of interests (ROIs), the forceps minor and corticospinal tracts, were then separately evaluated. Within each ROI, statistical comparisons of results from the INPH and control groups were performed. In addition, for INPH patients, grading scores for clinical symptoms and FA values were correlated. The forceps minor mean FA value was much smaller for the INPH group (0.504) than for the control group (0.631). The corticospinal tract mean FA value was slightly smaller for the INPH group (0.588) than for the control group (0.632). Additional analyses indicated that lower FA values within the forceps minor tended to be associated with clinical symptoms such as urinary incontinence and gait disturbance. Our findings indicate FA values decreased in the forceps minor of INPH patients. We also found that lower values were associated with severer clinical symptoms, implying that DTI techniques may be developed for more accurate diagnosis.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Dti Of Inphmentioning

confidence: 99%

Section: Dti Of Inphmentioning

confidence: 99%

See 2 more Smart Citations

Diffusion Tensor Imaging of Idiopathic Normal Pressure Hydrocephalus: A Voxel-Based Fractional Anisotropy Study

Koyama

Marumoto

Domen

et al. 2012

Neurol. Med. Chir.(Tokyo)

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“…However, the involvement of the CST in gait disturbance in patients with iNPH has been controversial in previous studies. 18,25,26 In contrast, a recent hypothesis for gait disturbance in patients with iNPH is frontal lobe dysfunction 27,28 and/or malfunction of the cortex-basal ganglia-thalamus-cortex circuit, including the supplementary motor cortex. 29 On the other hand, the origin of dementia in patients with iNPH is also unknown.…”

Section: Discussionmentioning

confidence: 98%

White Matter Alteration in Idiopathic Normal Pressure Hydrocephalus: Tract-Based Spatial Statistics Study

Hattori¹,

Ito²,

Aoki³

et al. 2011

AJNR Am J Neuroradiol

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Alterations in white matter microstructure are associated with goal‐directed upper‐limb movement segmentation in children born extremely preterm

Lenfeldt

Johansson

Domellöf

et al. 2017

Human Brain Mapping

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Altered white matter microstructure is commonly found in children born preterm (PT), especially those born at an extremely low gestational age (GA). These children also commonly show disturbed motor function. This study explores the relation between white matter alterations and upper-limb movement segmentation in 41 children born PT (19 girls), and 41 children born at term (18 girls) at 8 years. The PT group was subdivided into extremely PT (E-PT; GA = 25-27 weeks, N = 10), very PT (V-PT; GA = 28-32 weeks, N = 13), and moderately PT (M-PT; GA = 33-35 weeks, N = 18). Arm/hand preference (preferred/non-preferred) was determined through object interactions and the brain hemispheres were designated accordingly. White matter alterations were assessed using diffusion tensor imaging in nine areas, and movement segmentation of the body-parts head, shoulder, elbow, and wrist were registered during a unimanual goal-directed task. Increased movement segmentation was demonstrated consistently on the preferred side in the E-PT group compared with the term born group. Also compared with the term born peers, the E-PT group demonstrated reduced fractional anisotropy (FA) in the cerebral peduncle (targeting the corticospinal tract) in the hemisphere on the non-preferred side and in the splenium of corpus callosum. In contrast, in the anterior internal capsule on the preferred side, the E-PT group had increased FA. Lower FA in the cerebral peduncle, but higher FA in the anterior internal capsule, was associated with increased movement segmentation across body-parts in a contralateral manner. The results suggest that impaired development of sensorimotor tracts in E-PT children could explain a sub-optimal spatiotemporal organization of upper-limb movements. Hum Brain Mapp 38:5051-5068, 2017. © 2017 Wiley Periodicals, Inc.

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Diffusion Tensor Imaging in Patients With Adult Chronic Idiopathic Hydrocephalus

Abstract: Microstructural changes in periventricular functionally relevant white matter structures (CSF, CC) in chronic idiopathic hydrocephalus can be visualized using DTI. Further studies should investigate the change of DTI parameters after CSF shunting and its relation to neurologic outcome.

Cited by 91 publications

References 26 publications

Diffusion Tensor Imaging of Idiopathic Normal Pressure Hydrocephalus: A Voxel-Based Fractional Anisotropy Study

Diffusion Tensor Imaging of Idiopathic Normal Pressure Hydrocephalus: A Voxel-Based Fractional Anisotropy Study

White Matter Alteration in Idiopathic Normal Pressure Hydrocephalus: Tract-Based Spatial Statistics Study

Alterations in white matter microstructure are associated with goal‐directed upper‐limb movement segmentation in children born extremely preterm

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