Diffusion tensor imaging in biomechanical studies of skeletal muscle function

Donkelaar, Corrinus C. van; Kretzers, L.J.G.; Bovendeerd, P.H.M.; Lataster, L. M. A.; Nicolay, Klaas; Janssen, JD Jan; Drost, Maarten R.

doi:10.1046/j.1469-7580.1999.19410079.x

Cited by 132 publications

(127 citation statements)

References 21 publications

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“…By combined DTI and anatomical studies of rat hindleg skeletal muscle, the diffusion tensor eigenvector that corresponds to the highest eigenvalue has been shown to represent the fiber direction (163,164). This finding agrees with the intuitive idea that diffusion of water is least hindered along the fibers (i.e.…”

Section: Diffusion Mri Of Fiber Architecture and Myocyte Integritysupporting

confidence: 79%

Dynamic MRS and MRI of skeletal muscle function and biomechanics

et al. 2006

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MR is a powerful technique for studying the biomechanical and functional properties of skeletal muscle in vivo in health and disease. This review focuses on 31 P, 1 H and 13 C MR spectroscopy for assessment of the dynamics of muscle metabolism and on dynamic 1 H MRI methods for non-invasive measurement of the biomechanical and functional properties of skeletal muscle. The information thus obtained ranges from the microscopic level of the metabolism of the myocyte to the macroscopic level of the contractile function of muscle complexes. The MR technology presented plays a vital role in achieving a better understanding of many basic aspects of muscle function, including the regulation of mitochondrial activity and the intricate interplay between muscle fiber organization and contractile function. In addition, these tools are increasingly being employed to establish novel diagnostic procedures as well as to monitor the effects of therapeutic and lifestyle interventions for muscle disorders that have an increasing impact in modern society.

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Section: Diffusion Mri Of Fiber Architecture and Myocyte Integritysupporting

confidence: 79%

Dynamic MRS and MRI of skeletal muscle function and biomechanics

et al. 2006

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“…For comparison with the literature data, the mean FA values in healthy human calf were approximately 0.32 for lg muscle, 0.28 for mg muscle, and 0.27 for soleus muscle (7). The mean FA for rat bipinnate skeletal muscle has been reported to be 0.259 (20), and for rat lateral gastrocnemius in vivo FA was 0.35 (19). Comparing mean FA values for controls and patients in Fig.…”

Section: Discussionmentioning

confidence: 68%

Diffusion tensor imaging in evaluation of human skeletal muscle injury

Zaraiskaya

Kumbhare

Noseworthy

2006

Magnetic Resonance Imaging

192

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Purpose: To explore the capability and reliability of diffusion tensor magnetic resonance imaging (DTI) in the evaluation of human skeletal muscle injury. Materials and Methods:DTI of four patients with gastrocnemius and soleus muscles injuries was compared to eight healthy controls. Imaging was performed using a GE 3.0T short-bore scanner. A diffusion-weighted 2D spin echo echo-planar imaging (EPI) pulse sequence optimized for skeletal muscle was used. From a series of axially acquired diffusion tensor images the diffusion tensor eigenparameters (eigenvalues and eigenvectors), fractional anisotropy (FA), and apparent diffusion coefficient (ADC) were calculated and compared for injured and healthy calf muscles. Two dimensional (2D) projection maps of the principal eigenvectors were plotted to visualize the healthy and pathologic muscle fiber architectures.Results: Clear differences in FA and ADC were observed in injured skeletal muscle, compared to healthy controls. Mean control FA was 0.23 Ϯ 0.02 for medial and lateral gastrocnemius (mg and lg) muscles, and 0.20 Ϯ 0.02 for soleus (sol) muscles. In all patients FA values were reduced compared to controls, to as low as 0.08 Ϯ 0.02. The ADC in controls ranged from 1.41 to 1.31 ϫ 10 -9 m 2 /second, while in patients this was consistently higher. The 2D projection maps revealed muscle fiber disorder in injured calves, while in healthy controls the 2D projection maps show a well organized (ordered) fiber structure. Conclusion:DTI is a suitable method to assess human calf muscle injury.

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“…DTI has been successfully applied to the analysis and depiction of neuronal fibers in the living human brain (Mori and van Zijl, 2002). Furthermore, qualitative agreement between main diffusion directions and the fiber orientation in myocardium (Garrido et al, 1994;Reese et al, 1995;Scollan et al, 1998;Schmid et al, 2005) and skeletal muscle (Van Donkelaar et al, 1999;Napadow et al, 2001;Damon et al, 2002;Mori and van Zijl, 2002;Heemskerk et al, 2005) was observed.…”

mentioning

confidence: 88%

Three‐dimensional fiber architecture of the nonpregnant human uterus determined ex vivo using magnetic resonance diffusion tensor imaging

et al. 2005

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The global muscle and collagen fiber orientation in the human uterus has been analyzed hitherto by various standard microscopic techniques. However, no widely accepted model of the fiber architecture of the myometrium could be acquired. The purpose of the present study was to investigate the uterus by magnetic resonance (MR) diffusion tensor imaging (DTI) in a 3D macroscopic approach. Ex vivo MR DTI measurements were performed on five uteri from nonpregnant patients. The main diffusion directions reflecting the orientation of directional structures in the examined tissues were determined from diffusion-weighted spin-echo measurements. A fiber tracking algorithm was used to extrapolate the fiber architecture. The method was validated against histological slides and indirectly through the analysis of leiomyomas, which exhibit less anisotropy than normal myometrium. Significant anisotropy was found in most regions of all examined nonpregnant human uteri. But only two systems of fibers were found running circularly along the intramural part of the uterine tubes. They merged caudally and built a close fitting envelope of circular layers around the uterine cavity. On the cervix, circular fibers were observed in the outer part as well as mostly longitudinal fibers in the inner part. These results confirm the existence of directional structures in the complex fiber architecture of the human uterus. They also indicate that MR DTI is a beneficial and complementary tool to standard microscopic techniques to determine the intrinsic fiber architecture in human organs.

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Diffusion tensor imaging in biomechanical studies of skeletal muscle function

Cited by 132 publications

References 21 publications

Dynamic MRS and MRI of skeletal muscle function and biomechanics

Dynamic MRS and MRI of skeletal muscle function and biomechanics

Diffusion tensor imaging in evaluation of human skeletal muscle injury

Three‐dimensional fiber architecture of the nonpregnant human uterus determined ex vivo using magnetic resonance diffusion tensor imaging

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