Diffusion tensor imaging findings diagnosis for patients with chronic kidney disease

Abstract

Background Chronic kidney disease (CKD) can lead to systemic inflammatory responses and other cardiovascular disease. Diffusion tensor imaging findings generated by gadolinium-based MRI (DTI-GBMRI) is regarded as a standard method for assessing the pathology of CKD. To evaluate the diagnostic value of DTI-MRI for renal histopathology and renal efficiency, renal fibrosis and damage, noninvasive quantification of renal blood flow (RBF) were investigated in patients with CKD.Methods CKD patients (n = 186) were recruited and underwent diagnosis of renal DTI-GBMRI or DTI-MRI to identify the pathological characteristics and depict renal efficiency. The cortical RBFs and estimated glomerular filtration rate (eGFR) were compared in CKD patients undergone DTI-GBMRI (n=92) or DTI-MRI (n=94). Results Results showed that gadolinium enhanced the diagnosis generated by DTI-MRI in renal fibrosis, renal damage and eGFR. The superiority in sensitivity and accuracy of DTI-GBMRI method in assessing renal function and evaluating renal impairment was observed in CKD patients compared with DTI-MRI. Outcomes demonstrated that DTI-GBMRI had higher accuracy, sensitivity and specificity than DTI-MRI in diagnosing patients with CKD. Conclusions In conclusion, these outcomes indicate that DTI-GBMRI is a potential noninvasive method for measuring renal function, which can provide valuable information for clinical CKD diagnosis (Trial registration number: ChiCTR-IPR-16010073, 02/12/2016, registered status).

Recent advances in medical image processing for the evaluation of chronic kidney disease

“…Recently, DTI parameters, FA and track length were shown to be significantly different between kidneys with and without Uretero Pelvic Junction (UPJ) obstruction, supporting that DTI is able to assess parenchymal damage (Otero et al, 2020). Moreover, Gadolinium-based DTI was reported to be more accurate in measuring renal pathological characteristics, renal fibrosis and renal blood flow in CKD patients stage I and II (60<=eGFR<=90 mL/min/1.73 m 2 ) (Liu et al, 2020). Alterations in diffusion parameters caused by Renal Artery Stenosis (RAS), a renal disease promoting fibrosis by collagen deposition, could be detected by DTI were medullary FA was significantly reduced in patients with RAS (Gaudiano et al, 2020).…”