Diffusion tensor imaging (DTI) and tractography of the cerebellar projections to prefrontal and posterior parietal cortices: A study at 3T

Jissendi, Patrice; Baudry, Stéphane; Balériaux, Danielle

doi:10.1016/j.neurad.2007.11.001

Cited by 79 publications

(54 citation statements)

References 24 publications

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“…However, as the DN represents the sole neocerebellar output, it could be inferred that it also takes part in the executive control network and the default-mode network in relation to lobule VII (crus I and II) and lobule IX, respectively. These functional results are in line with human structural data based on tractography showing cerebellar projections from the dentate nucleus to prefrontal and posterior parietal cortices [56,57]. More generally, these results strongly agree with and support the emerging concept of cerebellar contribution to higher function mainly based upon: (1) histological studies tracing in monkey afferents to the cerebellum from associative cortex [58] and to prefrontal cortex [59] and dentate efferents to prefrontal and parietal cortices [60]; (2) functional imaging studies showing activation of the cerebellar cortex during executive, visuo-spatial, linguistic, and emotional tasks [61]; and (3) clinical data showing cerebellar morphological abnormalities in psychiatric disorders [62] and the existence of a specific cerebellar cognitive and affective syndrome caused by focal cerebellar lesions in adults [63] and in children [64].…”

Section: Dentate Nucleussupporting

confidence: 87%

Functional Imaging of the Deep Cerebellar Nuclei: A Review

Habas

2009

Cerebellum

107

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The present mini-review focused on functional imaging of human deep cerebellar nuclei, mainly the dentate nucleus. Although these nuclei represent the unique output channel of the cerebellum, few data are available concerning their functional role. However, the dentate nucleus has been shown to participate in a widespread functional network including sensorimotor and associative cortices, striatum, hypothalamus, and thalamus, and plays a minor role in motor execution and a major role in sensorimotor coordination and learning, and cognition. The dentate nucleus appears to be predominantly involved in conjunction with the neocerebellum in executive and affective networks devoted, at least, to attention, working memory, procedural reasoning, and salience detection.

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Section: Dentate Nucleussupporting

confidence: 87%

Functional Imaging of the Deep Cerebellar Nuclei: A Review

Habas

2009

Cerebellum

107

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“…We found STN DBS enhanced glucose metabolism in the occipital and parietal cortices, whereas it inhibited the glucose metabolism in the frontal cortex and cerebellar cortex. These findings suggest that STN DBS intervenes in the CSTC circuitry, including deactivating the premotor cortex and cerebellum, and activating the somatosensory cortex and related cerebellocortical pathways, which is consistent with a previous study [4,8,9,10]. PD with autonomic failure has been reported to present a markedly reduced glucose metabolism in the occipital cortex, inferior parietal cortex and superior parietal cortex [4].…”

Section: Discussionsupporting

confidence: 91%

Modified Fluorodeoxyglucose Metabolism in Motor Circuitry by Subthalamic Deep Brain Stimulation

Cao

Zhang²,

Li³

et al. 2017

Stereotact Funct Neurosurg

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Background: Adjustment of the motor circuitry has been described in the treatment of Parkinson disease (PD). Objectives: To evaluate the modulation of the motor circuitry of PD patients by subthalamic deep brain stimulation (STN DBS) using ¹⁸F-fluorodeoxyglucose (FDG) and positron emission tomography (PET). Methods: Resting-state brain ¹⁸F-FDG PET imaging was performed for 8 PD patients before surgery and also 1 year after STN DBS treatment; changes in regional glucose metabolism were identified. The PD-related pattern (PDRP) of metabolic covariation was also evaluated. In addition, the correlations between glucose metabolism and clinical alleviation were determined. Results: Pronounced elevations in parietal and occipital glucose metabolism due to STN DBS modification were found; an obvious reduction in caudate, putamen, cerebellum, and frontal cortex glucose metabolism was detected after STN DBS interventions. The alleviation of rigidity correlated with an increment in glucose metabolism in the parietal lobe. STN DBS inhibited the PDRP; the decrease in the PDRP correlated with the inhibition of the glucose metabolism of the caudate and the augmented glucose metabolism of the occipital lobe. Conclusion: STN DBS modulates cortical function through the cortical-striatothalamocortial motor circuitry and cerebellothalamocortical motor circuitry.

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“…Cerebellar and cerebral areas co-activate during the performance of a wide range of cognitive tasks (Balsters et al, 2014;Stoodley and Schmahmann, 2009) and several studies using resting state functional magnetic resonance imaging (fMRI) report functional connectivity between the cerebellum and cerebral networks involved in both cognitive functions and motor control (Bernard et al, 2014;Buckner et al, 2011;Habas et al, 2009;Krienen and Buckner, 2009;O'Reilly et al, 2010;Ramnani, 2006;Sang et al, 2012). In line with these observations, diffusion tensor imaging (DTI) based tractography has provided evidence for white-matter tracts between the dentate nucleus -a major source of cerebellar output -and prefrontal and parietal areas (Jissendi et al, 2008;Palesi et al, 2014;Ramnani, 2006), suggesting extensive structural connections between the cerebellum and the associative cerebral cortex in humans.…”

Section: Introductionmentioning

confidence: 84%