Diffusion tensor imaging and voxel based morphometry study in early progressive supranuclear palsy

Padovani, Alessandro; Borroni, Barbara; Brambati, Simona Maria; Agosti, Chiara; Broli, Marcella; Alonso, Raphael; Scifo, Paola; Bellelli, Giuseppe; Alberici, Antonella; Gasparotti, Roberto; Perani, Daniela

doi:10.1136/jnnp.2005.075713

Cited by 170 publications

(176 citation statements)

References 35 publications

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“…34 -37 Reduced glucose metabolism has also been found in the cerebellar cortex 38 and cerebral atrophy in the anterior insula. 34 The atrophy found in PSP is similar to that found in FTD: frontal 39 -41 and temporal lobes, 41 caudate nuclei 39 -40,42 -45 and insula 46 seem to be affected. Glucose hypometabolism of atrophy, although one study did find atrophy in the head of the caudate nuclei.…”

Section: Discussionmentioning

confidence: 62%

H1 haplotype of the MAPT gene is associated with lower regional gray matter volume in healthy carriers

et al. 2008

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The microtubule-associated protein Tau (MAPT) gene codes for the protein Tau that is involved in the pathogenesis of neurodegenerative diseases. Recent studies have detected an over-representation of the H1 haplotype of the MAPT gene in neurodegenerative disorders such as progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), frontotemporal dementia (FTD) and Parkinson's disease (PD), whereas the H2 haplotype has been found to be related to familial FTD. We aimed to investigate the association between MAPT haplotype status and brain morphology in healthy adults. A total of 150 healthy subjects underwent 3D high-resolution magnetic resonance (MR). MR images were processed following an optimized protocol to perform the Voxel-based morphometry (VBM) comparisons of the gray matter (GM) in H1 carriers (n ¼ 141) in contrast to H2H2 homozygous (n ¼ 9), and H1H1 homozygous (n ¼ 85) in contrast to H2 carriers (n ¼ 65). The threshold for statistical significance was 0.005 uncorrected. Opposite comparisons were also carried out. The groups had similar demographic and cognitive features. Compared with H2H2, the H1 carriers showed up to 19% smaller GM volume in the head of the right caudate nucleus, in the right middle frontal gyrus, in the left insula and orbito-frontal cortex, and in the inferior temporal and inferior cerebellar lobes, bilaterally. Compared with all H2 carriers, H1H1 displayed lower GM in the same regions, but the effect was smaller (5%), possibly due to a dilution effect by H1 in the H2 carriers group. The data suggest that H1 haplotype is associated with a particular cerebral morphology that may increase the susceptibility of the healthy carriers to develop neurodegenerative diseases such as sporadic tauopathies.

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Section: Discussionmentioning

confidence: 62%

H1 haplotype of the MAPT gene is associated with lower regional gray matter volume in healthy carriers

et al. 2008

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“…ADC in CC1 was significantly higher in PSP than controls. Three other studies 27,30,32 also detected reductions in FA in at least 1 region of the CC and 1 study 29 detected an increase. One of 10 studies in PSP detected elevated FA in at least 1 region.…”

Section: Resultsmentioning

confidence: 86%

Diffusion tensor imaging in parkinsonian syndromes

2013

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Objectives: We performed a systematic review to assess alterations in measures of diffusion tensor imaging (DTI) in parkinsonian syndromes, exploring the potential role of DTI in diagnosis and as a candidate biomarker. Methods:We searched EMBASE and Medline databases for DTI studies comparing parkinsonian syndromes or related dementias with controls or another defined parkinsonian syndrome. Key details for each study regarding participants, imaging methods, and results were extracted. Estimates were pooled, where appropriate, by random-effects meta-analysis. Results:Of 333 results, we identified 43 studies suitable for inclusion (958 patients, 764 controls). DTI measures detected alterations in all parkinsonian syndromes, with distribution varying differentially with disease type. Nine studies were included in a meta-analysis of the substantia nigra in Parkinson disease. A notable effect size was found for lowered fractional anisotropy in the substantia nigra for patients with Parkinson disease vs controls (20.639, 95% confidence interval 20.860 to 20.417, p , 0.0001).Conclusion: DTI may be a promising biomarker in parkinsonian syndromes and have a future role in differential diagnosis. Larger cohort studies are required to investigate some encouraging preliminary findings. Given the complexity of the parkinsonian syndromes, it is likely that any potential DTI biomarker would be used in combination with other relevant biomarkers. Differences in natural history and therapy options make early and accurate diagnosis of parkinsonian syndromes important. 1 Emission tomography (SPECT or PET) has a role but it can be expensive, with limited availability, and requires radioactive tracers. 2 There is particular interest in the potential of advanced structural MRI techniques to differentiate among parkinsonian syndromes and to offer candidate biomarkers, facilitating early or premanifest diagnosis and monitoring of disease progression.Diffusion tensor imaging (DTI) is an MRI technique assessing the orientation and integrity of white matter tracts in vivo by measuring the diffusion of water molecules in neural fibers 3 and it also shows promise for studying gray matter areas. It estimates both the degree of directionality using anisotropy (frequently fractional anisotropy [FA]) and the overall movement of molecules (mean diffusivity [MD]; trace; apparent diffusion coefficient [ADC]). These measurements can either be extracted locally in predefined regions using region of interest (ROI) analysis or tractography or, alternatively, globally using voxel-based analysis (VBA) or tract-based spatial statistics (TBSS). Disruptions to microstructural tissue integrity, such as those found in the neurodegeneration of parkinsonian syndromes can be associated with alterations in anisotropy and diffusivity measures. 3 We therefore performed a systematic review of the literature to assess

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“…27,28,32 To our knowledge, this study is the first to show that the superior longitudinal fasciculus, known to degenerate in PSP, is also affected in patients with PD with no dementia. 33 Although its exact functional correlates remain unclear, the cingulum subserves communication among different components of the limbic system and is involved in emotion formation, response initiation, and inhibition, as well as in learning. 34 Atrophy in the limbic and paralimbic regions occurs in patients without dementia, though less markedly than in patients with dementia.…”

Section: Discussionmentioning

confidence: 99%

White Matter Involvement in Idiopathic Parkinson Disease: A Diffusion Tensor Imaging Study

Gattellaro¹,

Minati²,

Grisoli³

et al. 2009

AJNR Am J Neuroradiol

215

164

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Diffusion tensor imaging and voxel based morphometry study in early progressive supranuclear palsy

Abstract: These data provide evidence for both grey and white matter degeneration in PSP from the early disease stage. These structural changes suggest that atrophy of cortical and subcortical structures and neurodegeneration of specific fibre tracts contribute to neurological deficits in PSP.

Cited by 170 publications

References 35 publications

H1 haplotype of the MAPT gene is associated with lower regional gray matter volume in healthy carriers

H1 haplotype of the MAPT gene is associated with lower regional gray matter volume in healthy carriers

Diffusion tensor imaging in parkinsonian syndromes

White Matter Involvement in Idiopathic Parkinson Disease: A Diffusion Tensor Imaging Study

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