Diffusion tensor imaging and tractography to evaluate sacral nerve root abnormalities in endometriosis-related pain: A pilot study

Manganaro, Lucia; Porpora, Maria Grazia; Vinci, Valeria; Bernardo, Silvia; Lodise, Pietro; Sollazzo, Paolo; Sergi, Maria Eleonora; Saldari, Matteo; Pace, Gianvito; Vittori, Giorgio; Catalano, Carlo; Pantano, P.

doi:10.1007/s00330-013-2981-0

Cited by 47 publications

(35 citation statements)

References 28 publications

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“…New modalities for the study of women with chronic pelvic pain are being developed using 3T MRI as described in a recent study dealing with the feasibility of diffusion tensor imaging and tractography in abnormalities of the sacral roots [63].…”

Section: Deep Infiltrating Endometriosis Of the Posterior-lateral Commentioning

confidence: 99%

Imaging for the evaluation of endometriosis and adenomyosis

Exacoustòs

Manganaro

Zupi

2014

Best Practice & Research Clinical Obstetrics & Gynaecol

204

143

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Endometriosis affects between 5 and 45% of women in reproductive age, is associated with significant morbidity, and constitutes a major public health concern. The correct diagnosis is fundamental in defining the best treatment strategy for endometriosis. Therefore, non-invasive methods are required to obtain accurate diagnoses of the location and extent of endometriotic lesions. Transvaginal sonography and magnetic resonance imaging are used most frequently to identify and characterise lesions in endometriosis. Subjective impression by an experienced sonologist for identifying endometriomas by ultrasound showed a high accuracy. Adhesions can be evaluated by real-time dynamic transvaginal sonography, using the sliding sign technique, to determine whether the uterus and ovaries glide freely over the posterior and anterior organs and tissues. Diagnosis is difficult when ovarian endometriomas are absent and endometriosis causes adhesions and deep infiltrating nodules in the pelvic organs. Magnetic resonance imaging seems to be useful in diagnosing all locations of endometriosis, and its diagnostic accuracy is similar to those obtained using ultrasound. Transvaginal ultrasound has been proposed as first line-line imaging technique because it is well accepted and widely available. The main limitation of ultrasound concerns lesions located above the rectosigmoid junction owing to the limited field-of-view of the transvaginal approach and low accuracy in detecting upper bowel lesions by transabdominal ultrasound. A detailed non-invasive diagnosis of the extension in the pelvis of endometriosis can facilitate the choice of a safe and adequate surgical or medical treatment

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Section: Deep Infiltrating Endometriosis Of the Posterior-lateral Commentioning

confidence: 99%

Imaging for the evaluation of endometriosis and adenomyosis

Exacoustòs

Manganaro

Zupi

2014

Best Practice & Research Clinical Obstetrics & Gynaecol

204

143

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“…Among these metrics, the FA values consistently respond to nerve injury and consistently correlate with histological markers of nerve health[Morisaki et al, 2011], [Kakuda et al, 2011; Manganaro et al, 2014]. Studies in both human patients and animal models demonstrate that the FA values are significantly lower in injured nerves than in healthy nerves, due to the decrease in myelination and anisotropic diffusion [Morisaki et al, 2011; Kakuda et al, 2011; Mathys et al, 2013; Chhabra et al, 2013].…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

Noninvasive Imaging of Peripheral Nerves

Rangavajla

Mokarram

Masoodzadehgan

et al. 2014

Cells Tissues Organs

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Recent developments in the field of peripheral nerve imaging extend the capabilities of imaging modalities to assist in the diagnosis and treatment of patients with peripheral nerve maladies. Methods such as magnetic resonance imaging (MRI) and its derivative diffusion tensor imaging (DTI), ultrasound (US) and positron emission tomography (PET) are capable of assessing nerve structure and function following injury and relating the state of the nerve to electrophysiological and histological analysis. Of the imaging methods surveyed here, each offered unique and interesting advantages related to the field. MRI offered the opportunity to visualize immune activity on the injured nerve throughout the course of the regeneration process, and DTI offered numerical characterization of the injury and the ability to develop statistical bases for diagnosing injury. US extends imaging to the treatment phase by enabling more precise analgesic applications following surgery, and PET represents a novel method of assessing nerve injury through analysis of relative metabolism rates in injured and healthy tissue. Exciting new possibilities to enhance and extend the abilities of imaging methods are also discussed, including innovative contrast agents, some of which enable multimodal imaging approaches and present opportunities for treatment application.

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“…The MRI is increasingly used for endometriosis and CPP, and tractography can be used to show altered microstructure of sacral roots affected by endometriosis and CPP. 149 It is now possible under certain circumstances to image nerves and alterations in nerve properties noninvasively, to image receptor level expression and inflammatory processes in injured tissue, to image astrocyte and glial roles in neuroinflammatory processes, and to image pain conduction functionally in the trigeminal ganglion. 150 These advances will ultimately allow description of the pain pathway from injury site to behavioral consequence in a quantitative manner.…”

Section: Imagingmentioning

confidence: 99%

Research Priorities for Endometriosis: Recommendations From a Global Consortium of Investigators in Endometriosis

et al. 2017

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The 3rd International Consensus Workshop on Research Priorities in Endometriosis was held in São Paulo on May 4, 2014, following the 12th World Congress on Endometriosis. The workshop was attended by 60 participants from 19 countries and was divided into 5 main sessions covering pathogenesis/pathophysiology, symptoms, diagnosis/classification/prognosis, disease/ symptom management, and research policy. This research priorities consensus statement builds on earlier efforts to develop research directions for endometriosis. Of the 56 research recommendations from the 2011 meeting in Montpellier, a total of 41 remained unchanged, 13 were updated, and 2 were deemed to be completed. Fifty-three new research recommendations were made at the 2014 meeting in Sao Paulo, which in addition to the 13 updated recommendations resulted in a total of 66 new recommendations for research. The research recommendations published herein, as well as those from the 2 previous papers from international consensus workshops, are an attempt to promote high-quality research in endometriosis by identifying and

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Diffusion tensor imaging and tractography to evaluate sacral nerve root abnormalities in endometriosis-related pain: A pilot study

Cited by 47 publications

References 28 publications

Imaging for the evaluation of endometriosis and adenomyosis

Imaging for the evaluation of endometriosis and adenomyosis

Noninvasive Imaging of Peripheral Nerves

Research Priorities for Endometriosis: Recommendations From a Global Consortium of Investigators in Endometriosis

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