2004
DOI: 10.1007/s00223-004-0019-y
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Diffusion Systems for Evaluation of Biomineralization

Abstract: A variety of in vitro study methods have been used to elucidate the roles of matrix molecules in biomineralization processes. Among these, gel diffusion-precipitation studies have proved to be an effective tool. This methodology is uniquely capable of characterizing the effects of matrix molecules on mineralization while only using very small quantities of material. Furthermore, gel methods have been extended for use as a mineralization assay system to characterize modified matrix molecules and synthetic analo… Show more

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Cited by 83 publications
(84 citation statements)
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“…[1,2,16] Many in vitro studies have demonstrated the importance of proteins and peptides in controlling the nucleation and/or growth of crystals. [17] Biominerals are usually formed at the surface of organic matrices.…”
Section: Mechanismmentioning
confidence: 99%
“…[1,2,16] Many in vitro studies have demonstrated the importance of proteins and peptides in controlling the nucleation and/or growth of crystals. [17] Biominerals are usually formed at the surface of organic matrices.…”
Section: Mechanismmentioning
confidence: 99%
“…The advantages of double diffusion systems are that they not only need very little test molecule but also the slow diffusion process more realistically mimics the unique mineralized tissue matrix environment compared with non-gel solution studies [20]. The influence of PAMAM-MG on the morphology and phase of CaP crystals formed was also studied in a one way diffusion system without gels to investigate the contribution of the gel to the results in the double diffusion systems.…”
Section: Introductionmentioning
confidence: 99%
“…However, these methods form 2D mineralised surfaces on the biomaterial, which is not useful in bone repair and osseoregeneration processes. As 3D mineralization was observed in the hydrogels, very recently they started been used as a good model to study this process, in consequence that many mineralization processes take place in gelling environments [10][11][12]. Most of the research in this field was performed using physical gels such as gelatin, agarose, silica, starch, polyvinyl alcohol) hydrogels [2, 13,14]whilst only few studies were conducted with chemical gels [15].…”
Section: Introductionmentioning
confidence: 99%