Diffusion spectrum imaging of patients with middle cerebral artery stenosis

Wan, Xinghua; Yu, Xiao; Liu, Zhenghua

doi:10.1016/j.nicl.2022.103133

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…With the improvement in DSI data acquisition, more attention has recently been paid to its application in clinical diseases, including attention-deficit/hyperactivity disorder (ADHD) [2,64,65], schizophrenia [66][67][68], stroke [69][70][71][72], Parkinson's disease [73,74], hypertension [75], autism [76], epilepsy [77], and gliomas [78] (see Table 2).…”

Section: Clinical Applicationsmentioning

confidence: 99%

Research Progress in Diffusion Spectrum Imaging

Sun,

Huang,

Wang

et al. 2023

Brain Sciences

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Studies have demonstrated that many regions in the human brain include multidirectional fiber tracts, in which the diffusion of water molecules within image voxels does not follow a Gaussian distribution. Therefore, the conventional diffusion tensor imaging (DTI) that hypothesizes a single fiber orientation within a voxel is intrinsically incapable of revealing the complex microstructures of brain tissues. Diffusion spectrum imaging (DSI) employs a pulse sequence with different b-values along multiple gradient directions to sample the diffusion information of water molecules in the entire q-space and then quantitatively estimates the diffusion profile using a probability density function with a high angular resolution. Studies have suggested that DSI can reliably observe the multidirectional fibers within each voxel and allow fiber tracking along different directions, which can improve fiber reconstruction reflecting the true but complicated brain structures that were not observed in the previous DTI studies. Moreover, with increasing angular resolution, DSI is able to reveal new neuroimaging biomarkers used for disease diagnosis and the prediction of disorder progression. However, so far, this method has not been used widely in clinical studies, due to its overly long scanning time and difficult post-processing. Within this context, the current paper aims to conduct a comprehensive review of DSI research, including the fundamental principles, methodology, and application progress of DSI tractography. By summarizing the DSI studies in recent years, we propose potential solutions towards the existing problem in the methodology and applications of DSI technology as follows: (1) using compressed sensing to undersample data and to reconstruct the diffusion signal may be an efficient and promising method for reducing scanning time; (2) the probability density function includes more information than the orientation distribution function, and it should be extended in application studies; and (3) large-sample study is encouraged to confirm the reliability and reproducibility of findings in clinical diseases. These findings may help deepen the understanding of the DSI method and promote its development in clinical applications.

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Section: Clinical Applicationsmentioning

confidence: 99%

Research Progress in Diffusion Spectrum Imaging

Sun,

Huang,

Wang

et al. 2023

Brain Sciences

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“…Middle cerebral artery (MCA) atherosclerotic stenosis is an important cause of recurrent cerebral ischemic strokes (1)(2)(3)(4)(5)(6), and stent angioplasty is a valuable approach for treatment of severe MCA stenosis, mainly by endovascular revascularization to improve cerebral blood flow perfusion and prevent the occurrence of MCA stenosis-related hypoperfusion cerebral infarction (7,8). The Enterprise stent (Codman, Raynham, MA) was the second one to receive US FDA approval for stentassisted coiling and the first one with a closed-cell design.…”

Section: Introductionmentioning

confidence: 99%

Sub-satisfactory recanalization of severe middle cerebral artery stenoses can significantly improve hemodynamics

Zhang

Ren²,

Li³

et al. 2022

Front. Cardiovasc. Med.

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PurposeTo investigate the effect of sub-satisfactory stent recanalization on hemodynamic stresses for severe stenoses of the middle cerebral artery (MCA) M 1 segment.Materials and methodsPatients with severe stenoses of the MCA M1 segment treated with endovascular stent angioplasty were retrospectively enrolled. Three-dimensional digital subtraction angiography before and after stenting was performed; the computational fluid dynamics (CFD) analysis of hemodynamic stresses at the stenosis and normal segments proximal and distal to the stenoses was analyzed.ResultsFifty-one patients with severe stenosis at the MCA M1 segment were enrolled, with the stenosis length ranging from 5.1 to 12.8 mm (mean 9 ± 3.3 mm). Stent angioplasty was successful in all (100%) the patients. The angiography immediately after stenting demonstrated a significant (P < 0.05) decrease in MCA stenosis after comparison with before stenting (31.4 ±12.5% vs. 87.5 ± 9.6%), with residual stenosis of 15–30% (mean 22.4 ± 3.5%). Before stenting, the total pressure was significantly higher (P < 0.0001), while the WSS, velocity, and vorticity were all significantly decreased (P < 0.0001) at the normal arterial segment proximal to the stenosis, and the total pressure, WSS, velocity, and vorticity were all significantly decreased (P < 0.0001) at the normal arterial segment distal to the stenosis compared with those at the stenosis. After sub-satisfactory stenting recanalization, all the hemodynamic stresses proximal or distal to the stenosis and at the perforator root were improved compared with those before stenting and were similar to those after virtual stenosis removal.ConclusionSub-satisfactory recanalization of severe MCA stenoses can significantly improve the hemodynamic status for cerebral perfusion at the stenoses.

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Clinical characteristics of post-stroke basal ganglia aphasia and the study of language-related white matter tracts based on diffusion spectrum imaging

Han,

Jing,

et al. 2024

NeuroImage

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Diffusion spectrum imaging of patients with middle cerebral artery stenosis

Cited by 3 publications

References 32 publications

Research Progress in Diffusion Spectrum Imaging

Research Progress in Diffusion Spectrum Imaging

Sub-satisfactory recanalization of severe middle cerebral artery stenoses can significantly improve hemodynamics

Clinical characteristics of post-stroke basal ganglia aphasia and the study of language-related white matter tracts based on diffusion spectrum imaging

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