Diffusion of local anesthetics through liquid membranes

Majumdar, Amitav; Stroeve, Pieter

doi:10.1016/s0376-7388(00)82116-x

Cited by 6 publications

(10 citation statements)

References 6 publications

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“…Such and other supported liquid membranes (SLM) have been studied for a number of years (Lonsdale, 1982) as selective separation barriers. Various applications of SLM-s for liquid separations have been investigated (Kuo and Gregor, 1983;Danesi, 1984-8s;Nishiki and Bautista, 1985;Majumdar and Stroeve, 1986;Babcock et al, 1986). Extensive reviews are also available (Marr and Kopp, 1982;Way et al, 1982;Danesi et al, 1984-85).…”

Section: Introductionmentioning

confidence: 99%

Separation of solutes from aqueous solutions by contained liquid membranes

1988

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The hollow fiber contained liquid membrane (CLM) is a thin liquid film contained in the interstices of two sets of intermingled microporous hollow fine fibers. Organic CLM-s have been used here for the separation of solutes from an aqueous feed into an aqueous strip. Solutes studied are phenol and acetic acid. The separations are carried out in either hydrophilic or hydrophobic hollow fiber CLM permeator modules, using a variety of organic liquids (e.g., decanol, methyl isobutyl ketone, xylene) as membranes. First-order models have been developed to predict the overall solute transfer coefficients adequately. The transfer coefficient can be enhanced significantly when a chemical reaction is carried out on the strip side using NaOH. The advantages of the CLM structure include operational stability, independent control of membrane phase pressure, automatic replenishment of the lost membrane liquid, and absence of the need for preequilibration. These features are demonstrated here, even for systems with considerable aqueous-organic mutual solubilities.

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Section: Introductionmentioning

confidence: 99%

Separation of solutes from aqueous solutions by contained liquid membranes

1988

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“…The system chosen for the experimental studies is completely nonionic, and electrostatic forces between micelles and pores are absent. Further, the solubilizate, surfactant, and membrane have been well-characterized with respect to physical and chemical properties. ,, …”

Section: Methodsmentioning

confidence: 99%

“…The surfactant soaking treatment ensured that the walls of the pores became hydrophilic and, hence, filled with water. The choice of surfactant concentration of 2.5 × CMC was based on the approximate amount of membrane and solution volume to ensure the formation of a close-packed layer of surfactant molecules on the pore walls. , …”

Section: Methodsmentioning

confidence: 99%

Micelle-Mediated Transport of a Sparingly Soluble Drug through Nanoporous Membranes

Bhown¹,

Stroeve

2006

Ind. Eng. Chem. Res.

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Micelle-mediated solute transport through nanoporous membranes can considerably increase total solute transport compared to free diffusion of solute alone. Micelle-mediated solute transport is of importance in chemical modification of porous media and controlled-release applications when the solute is sparingly soluble in water. Experimental and theoretical results are given for the transport of a local anesthetic, n-butyl-paminobenzoate, dissolved in a micellar solution of iso-octylphenoxypolyethoxyethanol through nanoporous polypropylene membranes. The membranes have slit-like pores with a characteristic dimension of 40 nm. The theory, based on the phase-separation model, is in good agreement with the experimental results on micelle-mediated transport of the anesthetic through the nanoporous membranes. Hindered diffusion of micelles inside the slit-like pores is taken into account in the theory since the micelles are spherical with a diameter of 9.28 nm.

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“…Diffusivities are calculated using the relation P = KD (where P: permeability, K: partition coefficient, D: diffusivity), and assuming that the partition coefficient is 1.0 for the large pore size relative to the protein size. [26][27][28] Since the pore size is relatively large compared to the solute size and the ionic strength is relatively high leading to a small Debye length, pore hindrance and geometric exclusion effects are small. Therefore, the diffusivity of the protein in the pore should approach the value of the bulk diffusivity and the partition coefficient in the pore should approach the value of one.…”

Section: Pccp Papermentioning

confidence: 99%

Molecular transport of proteins through nanoporous membranes fabricated by interferometric lithography

Ileri

Faller

Palazoğlu

et al. 2013

Phys. Chem. Chem. Phys.

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Millimeter sized arrays of uniformly-distributed nanopores (180-220 nm) were created in thin (200 nm) silicon nitride membranes using interferometric lithography. Molecular transport properties of the fabricated devices were investigated experimentally and compared with those of state-of-the-art polycarbonate track etched membranes. Two similarly-sized proteins, bovine serum albumin (BSA) and bovine hemoglobin (BHb), were used as permeates in the transport experiments. Up to 40 fold higher pore fluxes were achieved with unmodified silicon nitride membranes relative to thicker commercial nanoporous membranes. Similarly, in mixed protein experiments, ∼5.0 and 1.9 fold higher BSA and BHb selectivities were obtained with fabricated thin membranes at pH 4.7 and 7.0, respectively, relative to the commercial nanoporous membranes.

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Diffusion of local anesthetics through liquid membranes

Cited by 6 publications

References 6 publications

Separation of solutes from aqueous solutions by contained liquid membranes

Separation of solutes from aqueous solutions by contained liquid membranes

Micelle-Mediated Transport of a Sparingly Soluble Drug through Nanoporous Membranes

Molecular transport of proteins through nanoporous membranes fabricated by interferometric lithography

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