Diffusion of levofloxacin mesylate in agarose hydrogels monitored by a refractive‐index method

Abstract

The diffusion of levofloxacin mesylate (MSALVFX) within agarose hydrogels was investigated by an improved refractive-index method. The diffusion coefficient of MSALVFX in infinite dilution (D 0 ) was obtained as 4.01 Â 10 À6 cm 2 /s (25 C) through extrapolation according to Kohlrausch's law. The diffusion behavior of MSALVFX under conditions of different solute concentrations, polymer volume fractions, and temperatures was studied in detail. In the considered range of agarose concentrations (0.5-2.5%, w/w), the ratio of D g to D 0 (where D g is the effective diffusion coefficient of MSALVFX in the agarose hydrogel) decreased from 0.938 to 0.835 because of the retardance effect of agarose fiber. Furthermore, the experimental data were analyzed with the Amsden, Clague and Philips, and Ogston models, and the data fit the Amsden model best.

Polyelectrolyte Complex Materials Consisting of Antibacterial and Cell‐Supporting Layers

“…Figure 3c shows that this loss profile fits a diffusion coefficient of 10 −7 cm 2 · s −1 . The calculated diffusion coefficient of levofloxacin in the film is slower compared to that in water (40 × 10 −7 cm 2 · s −1 , albeit at lower temperature 25 °C) 30. Regardless of the difference in temperature it is clear that levofloxacin mobility is retarded due to the effect of the chitosan network, i.e., available space for diffusion through the chitosan mesh 31…”

Non-invasive measurement of oxygen diffusion in model foods

“…This model is applicable for heterogonous hydrogel with very stiff polymer chains (Amsden, 1998b). Mathematical models based on physical parameters were used to describe the diffusion of solutes such as proteins in agarose (Johnson et al, 1996;Liang et al, 2006), alginate (Amsden, 1998a), and drugs in agarose (Dai et al, 2011). However, to our knowledge, none of the mathematical models based on physical parameters were used to model gas diffusion in hydrogels.…”