Diffusion Mediates Molecular Transport through the Perivascular Space in the Brain
Marie Tanaka,
Yoko Hirayoshi,
Shinobu Minatani
et al.
Abstract:The perivascular space has been proposed as a clearance pathway for degradation products in the brain, including amyloid β, the accumulation of which may induce Alzheimer’s disease. Live images were acquired using a two-photon microscope through a closed cranial window in mice. In topical application experiments, the dynamics of FITC-dextran were evaluated from 30 to 150 min after the application and closure of the window. In continuous injection experiments, image acquisition began before the continuous injec… Show more
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