Diffusion Measure Changes of Substantia Nigra Subregions and the Ventral Tegmental Area in Newly Diagnosed Parkinson’s Disease

Shim, Jae-Hyuk; Baek, Hyeon‐Man

doi:10.5607/en21025

Cited by 2 publications

(1 citation statement)

References 45 publications

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“…However, such associations had neither been assessed using neuropathologic evaluations nor in the context of clinical AD. Additional studies combining FDG-PET with imaging modalities aimed to evaluate SN degeneration in-vivo (44)(45)(46)(47) would be of great interest for replicating and studying these associations in larger observational cohorts.…”

Section: Discussionmentioning

confidence: 99%

Differential Effects of Tau Stage, Lewy Body Pathology, and Substantia Nigra Degeneration on¹⁸F-FDG PET Patterns in Clinical Alzheimer Disease

Silva‐Rodríguez

Labrador‐Espinosa²,

Moscoso³

et al. 2022

J Nucl Med

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Purpose: Comorbid Lewy body (LB) pathology is common in AD. The effect of LB co-pathology on FDG-PET patterns in AD is yet to be studied. We analysed associations of neuropathologically-assessed tau pathology, LB pathology, and substantia nigra neuron loss (SNnl) with ante-mortem FDG-PET hypometabolism in patients with a clinical AD presentation.Methods: Twenty-one patients with autopsy-confirmed AD ('pure-AD'), 24 with AD and LB co-pathology ('AD-LB'), and 7 with LB but no or low evidence of AD pathology ('pure-LB') were studied. Pathologic groups were compared on regional and voxel-wise FDG-PET patterns, the cingulate island sign ratio (CISr), and neuropathological ratings of SNnl. Additional analyses assessed continuous associations of Braak tangle stage and SNnl with FDG-PET patterns.Results: Pure-AD and AD-LB showed highly similar patterns of AD-typical temporo-parietal hypometabolism and did not differ in CISr, regional FDG SUVR, or SNnl. By contrast, pure-LB showed the expected DLB-like pattern, accompanied by pronounced occipital hypometabolism and elevated CISr and SNnl compared to the AD groups. In continuous analyses, Braak tangle stage was significantly correlated with more AD-like, and SNnl with more DLB-like, FDG-PET patterns. Conclusions:In autopsy-confirmed AD dementia patients, comorbid LB pathology did not have a notable effect on the regional FDG-PET pattern. A more DLB-like FDG-PET pattern was observed in relation to SNnl, but advanced SNnl was mostly limited to relatively pure LB cases. AD pathology may have a dominant effect over LB pathology in determining the regional neurodegeneration phenotype.

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Section: Discussionmentioning

confidence: 99%

Differential Effects of Tau Stage, Lewy Body Pathology, and Substantia Nigra Degeneration on¹⁸F-FDG PET Patterns in Clinical Alzheimer Disease

Silva‐Rodríguez

Labrador‐Espinosa²,

Moscoso³

et al. 2022

J Nucl Med

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Four-modality imaging of unmedicated subjects with schizophrenia: 18F-fluorodeoxyglucose and 18F-fallypride PET, diffusion tensor imaging, and MRI

Buchsbaum

Mitelman

Christian

et al. 2022

Psychiatry Research: Neuroimaging

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Diffusion Measure Changes of Substantia Nigra Subregions and the Ventral Tegmental Area in Newly Diagnosed Parkinson’s Disease

Cited by 2 publications

References 45 publications

Differential Effects of Tau Stage, Lewy Body Pathology, and Substantia Nigra Degeneration on¹⁸F-FDG PET Patterns in Clinical Alzheimer Disease

Differential Effects of Tau Stage, Lewy Body Pathology, and Substantia Nigra Degeneration on¹⁸F-FDG PET Patterns in Clinical Alzheimer Disease

Four-modality imaging of unmedicated subjects with schizophrenia: 18F-fluorodeoxyglucose and 18F-fallypride PET, diffusion tensor imaging, and MRI

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Diffusion Measure Changes of Substantia Nigra Subregions and the Ventral Tegmental Area in Newly Diagnosed Parkinson’s Disease

Cited by 2 publications

References 45 publications

Differential Effects of Tau Stage, Lewy Body Pathology, and Substantia Nigra Degeneration on18F-FDG PET Patterns in Clinical Alzheimer Disease

Differential Effects of Tau Stage, Lewy Body Pathology, and Substantia Nigra Degeneration on18F-FDG PET Patterns in Clinical Alzheimer Disease

Four-modality imaging of unmedicated subjects with schizophrenia: 18F-fluorodeoxyglucose and 18F-fallypride PET, diffusion tensor imaging, and MRI

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Differential Effects of Tau Stage, Lewy Body Pathology, and Substantia Nigra Degeneration on¹⁸F-FDG PET Patterns in Clinical Alzheimer Disease

Differential Effects of Tau Stage, Lewy Body Pathology, and Substantia Nigra Degeneration on¹⁸F-FDG PET Patterns in Clinical Alzheimer Disease