Diffusion kurtosis imaging in diffuse axonal injury

Захарова, Н. Е.; Потапов, А. А.; Pronin, Igor; Danilov, Gleb; Aleksandrova, E V; Фадеева, Л. М.; Pogosbekyan, E L; Баталов, А И; Goryaynov, S A

doi:10.17116/neiro2019830315

“…For the long-term period, additional correlations are present for the cortical segments. The demonstrated importance of the splenium for the recovery of consciousness aligns with other studies (Arenth et al 2014;Zakharova et al 2010;Zhang et al 2017). This may be apparently explained by presence of the largest number of dense nerve bers with similar directions.…”

Section: Discussionsupporting

confidence: 90%

Significance of the Corpus Callosum and Inferior Fronto-Occipital Fasciculus in Recovery after Traumatic Brain Injury

Pogosbekian,

Sharova,

Fadeeva

et al. 2024

Preprint

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Objective: To analyze the correlations between the consciousness state scores and the fractional anisotropy (FA) values in various segments of the Corpus Callosum (CC) and Inferior Fronto-Occipital Fasciculus (IFOF) at different stages of recovery after traumatic brain injury (TBI). Methods: Diffusion tensor imaging (DTI) was performed in 43 TBI patients and 22 healthy volunteers. The consciousness levels were estimated with the CRS-R scale. The tracts were divided into segments using a template based on tractograms of healthy volunteers, and the correlations between the CRS-R scores and the FA values were calculated for each tract segment. Results: In the acute period after TBI, 15 segments of the CC and IFOF demonstrated significant correlations (p<0.05). In the long-term period, the highest number (24) of correlations were found in the studied tracts segments. In the subacute period, only 3 segments with correlations were detected. Conclusions: We propose a new pipeline, which yields spatial localization of correlations between the fractional anisotropy values and the CRS-R scores in patients after TBI. It allows to make assumptions about the functioning of neural networks. Significance: This work provides new information concerning the organization of fiber tracts and neural networks in TBI patients and may improve neurorehabilitation approaches.

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“…For the long-term period, additional correlations are present for the cortical segments. The demonstrated importance of the splenium for the recovery of consciousness aligns with other studies (Arenth et al 2014;Zakharova et al 2010;Zhang et al 2017).…”

Section: Discussionsupporting

confidence: 90%

Significance of the Corpus Callosum and Inferior Fronto-Occipital Fasciculus in Recovery after Traumatic Brain Injury

Pogosbekian,

Sharova,

Fadeeva

et al. 2024

Preprint

0

View full text Add to dashboard Cite

Objective: To analyze the correlations between the consciousness state scores and the fractional anisotropy (FA) values in various segments of the Corpus Callosum (CC) and Inferior Fronto-Occipital Fasciculus (IFOF) at different stages of recovery after traumatic brain injury (TBI). Methods: Diffusion tensor imaging (DTI) was performed in 43 TBI patients and 22 healthy volunteers. The consciousness levels were estimated with the CRS-R scale. The tracts were divided into segments using a template based on tractograms of healthy volunteers, and the correlations between the CRS-R scores and the FA values were calculated for each tract segment. Results: In the acute period after TBI, 15 segments of the CC and IFOF demonstrated significant correlations (p<0.05). In the long-term period, the highest number (24) of correlations were found in the studied tracts segments. In the subacute period, only 3 segments with correlations were detected. Conclusions: We propose a new pipeline, which yields spatial localization of correlations between the fractional anisotropy values and the CRS-R scores in patients after TBI. It allows to make assumptions about the functioning of neural networks. Significance: This work provides new information concerning the organization of fiber tracts and neural networks in TBI patients and may improve neurorehabilitation approaches.

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“…Diffusion-kurtosis imaging (DKI) is an advanced MRI modality capable of reflecting neuronal damage in the gray and white matter of the brain, which is not visualized with standard MRI sequences [1]. However, its application in DAI is extremely rare, and to date, it has been limited to calculating only average values of DKI maps within regions of interest (ROIs) [2]. We believe that applying radiomics to analyze the signal intensity distribution in various ROIs across different DKI parametric maps can enhance the informativeness of DKI in TBI.…”

Section: Introductionmentioning

confidence: 99%

Radiomics Enhances Diagnostic and Prognostic Value of Diffusion Kurtosis Imaging in Diffuse Axonal Injury

Danilov,

Afandiev,

Pogosbekyan

et al. 2023

Telehealth Ecosystems in Practice

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The aim of our study was to investigate the potential of advanced radiomics in analyzing diffusion kurtosis MRI (DKI) to increase the informativeness of DKI in diffuse axonal injury (DAI). We hypothesized that DKI radiomic features could be used to detect microstructural brain injury and predict outcomes in DAI. The study enrolled 31 patients with DAI (mean age 31.48 ± 11.10 years, 8 (25.8%) female) and 12 healthy volunteers (mean age 33.67 ± 11.06 years, 4 (33.3%) female). A total of 342,300 radiomic features were calculated (2282 features per each combination of 10 parametric DKI maps with 15 ROIs). Our results showed that several radiomic features were capable of distinguishing between healthy and injured brain tissue and accurately predicting outcomes with an accuracy of over 0.9. Advanced DKI radiomic features show high diagnostic and prognostic potential in DAI and may outperform average ROI values in DKI maps.

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Diffusion kurtosis imaging in diffuse axonal injury

Cited by 8 publications

References 34 publications

Significance of the Corpus Callosum and Inferior Fronto-Occipital Fasciculus in Recovery after Traumatic Brain Injury

Significance of the Corpus Callosum and Inferior Fronto-Occipital Fasciculus in Recovery after Traumatic Brain Injury

Significance of the Corpus Callosum and Inferior Fronto-Occipital Fasciculus in Recovery after Traumatic Brain Injury

Radiomics Enhances Diagnostic and Prognostic Value of Diffusion Kurtosis Imaging in Diffuse Axonal Injury

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