Diffusion kurtosis imaging–derived histogram metrics for prediction of resistance to neoadjuvant chemoradiotherapy in rectal adenocarcinoma: Preliminary findings

Li, Dandan; Cui, Yanfen; Hou, Lina; Bian, Zeyu; Yang, Zhao; Xu, Ruxin; Jia, Yaju; Wu, Zhiyong; Yang, Xiaotang

doi:10.1016/j.ejrad.2021.109963

Cited by 4 publications

(1 citation statement)

References 29 publications

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“…Current evidence of aging-associated biomarker in PLWH includes monocyte activation markers [ 45 ], neurofilament light chain (NFL) [ 9 , 45 ], inflammatory cytokines, and cell-based activation [ 46 ]. However, these markers are from peripheral blood, which may not fully reflect the neuropathology associated with aging.…”

Section: Discussionmentioning

confidence: 99%

Accelerated Neuroimmune Dysfunction in Aged HIV-1-Infected Humanized Mice

Zhang,

Su,

Waight

et al. 2024

Pharmaceuticals

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Disordered immunity, aging, human immunodeficiency virus type one (HIV-1) infection, and responses to antiretroviral therapy are linked. However, how each factor is linked with the other(s) remains incompletely understood. It has been reported that accelerated aging, advanced HIV-1 infection, inflammation, and host genetic factors are associated with host cellular, mitochondrial, and metabolic alterations. However, the underlying mechanism remains elusive. With these questions in mind, we used chronically HIV-1-infected CD34-NSG humanized mice (hu-mice) to model older people living with HIV and uncover associations between HIV-1 infection and aging. Adult humanized mice were infected with HIV-1 at the age of 20 weeks and maintained for another 40 weeks before sacrifice. Animal brains were collected and subjected to transcriptomics, qPCR, and immunofluorescence assays to uncover immune disease-based biomarkers. CD4+ T cell decline was associated with viral level and age. Upregulated C1QA, CD163, and CXCL16 and downregulated LMNA and CLU were identified as age-associated genes tied to HIV-1 infection. Ingenuity pathway analysis affirmed links to innate immune activation, pyroptosis signaling, neuroinflammation, mitochondrial dysfunction, cellular senescence, and neuronal dysfunction. In summary, CD34-NSG humanized mice are identified as a valuable model for studying HIV-1-associated aging. Biomarkers of immune senescence and neuronal signaling are both age- and virus-associated. By exploring the underlying biological mechanisms that are linked to these biomarkers, interventions for next generation HIV-1-infected patients can be realized.

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