Diffusion in Aqueous Solutions of Poly(ethylene glycol) at Low Concentrations

Waggoner, R. Allen; Blum, Frank D.; Lang, John C.

doi:10.1021/ma00112a010

Cited by 61 publications

(60 citation statements)

References 18 publications

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“…The relationship between log (r PEG ) and log (PEG molecular weight) was fitted to a line with an inclination of 0.53. This scaling coefficient (n) of 0.53 is close to that reported by Waggoner et al [33] and was larger than that by Shimada et al [34]. Because the range of PEG molecular weight in our study was relatively small, the calculated n might have some inaccuracy.…”

Section: Hydrodynamic Radius Of Peg Moleculessupporting

confidence: 83%

Relationship between molecular weight of poly(ethylene)glycol and intermolecular interaction of Taka-amylase A monomers

Onuma

Furubayashi

Shibata

et al. 2010

Journal of Crystal Growth

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Section: Hydrodynamic Radius Of Peg Moleculessupporting

confidence: 83%

Relationship between molecular weight of poly(ethylene)glycol and intermolecular interaction of Taka-amylase A monomers

Onuma

Furubayashi

Shibata

et al. 2010

Journal of Crystal Growth

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“…Considerable data have been accumulated regarding the diffusion coefficient of PEG and poly͑ethylene oxide͒ ͑PEO͒ in solution. [4][5][6][7][8][9][10][11][12][13][14] In 1971, Tanner et al 4 determined the self-diffusion coefficient, D, of PEO in CCl 4 by pulsed NMR methods. They found that the logarithmic function of D, ln D, is proportional to the polymer concentration in low molecular weight samples; whereas, for high molecular weight polymers, plots of ln D versus concentration exhibit a marked upward curvature.…”

Section: Introductionmentioning

confidence: 99%

Precise measurement of the self-diffusion coefficient for poly(ethylene glycol) in aqueous solution using uniform oligomers

Shimada

Kato

Saito

et al. 2005

The Journal of Chemical Physics

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Uniform poly(ethylene glycol) (PEG) oligomers, with a degree of polymerization n=1-40, were separated by preparative supercritical fluid chromatography from commercial monodispersed samples. Diffusion coefficients, D, for separated uniform PEG oligomers were measured in dilute solutions of deuterium oxide (D(2)O) at 30 degrees C, using pulsed-field gradient nuclear magnetic resonance. The measured D for each molecular weight was extrapolated to infinite dilution. Diffusion coefficients obtained at infinite dilution follow the scaling behavior of Zimm-type diffusion, even in the lower molecular weight range. Molecular-dynamics simulations for PEG in H(2)O also showed this scaling behavior, and reproduced close hydrodynamic interactions between PEG and water. These findings suggest that diffusion of PEG in water is dominated by hydrodynamic interaction over a wide molecular weight range, including at low molecular weights around 1000.

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“…The a value of 1.3 for CA(PEG) 4 indicates molecules that are close to rigid random coils, probably as a result of the cholic acid core. Based upon these experimental results, the scaling relations between radii and molecular masses ( R h ~ M v ) were established, where v ranges from 0.5–0.6 depending on whether the polymer is in a theta solvent or good solvent [33, 34]. Essentially, the scaling constant for the CA(PEG) 4 polymers were within the range of a random coil conformation, as for linear polymers [32].…”

Section: Resultsmentioning

confidence: 99%

Effects of amphiphilic star-shaped poly(ethylene glycol) polymers with a cholic acid core on human red blood cell aggregation

Janvier¹,

Zhu²,

Armstrong³

et al. 2013

Journal of the Mechanical Behavior of Biomedical Materials

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Elevated red blood cell (RBC) aggregation increases low-shear blood viscosity and is closely related to several pathophysiological diseases such as atherosclerosis, thrombosis, diabetes, hypertension, cancer, and hereditary chronic hemolytic conditions. Non-ionic linear polymers such as poly(ethylene glycol) (PEG) and Pluronic F68 have shown inhibitory effects against RBC aggregation. However, hypersensitivity reactions in some individuals, attributed to a diblock component of Pluronic F68, have been reported. Therefore, we investigated the use of an amphiphilic star-shaped PEG polymer based on a cholic acid core as a substitute for Pluronics to reduce RBC aggregation. Cholic acid is a natural bile acid produced in the human liver and therefore should assure biocompatibility. Cholic acid based PEG polymers, termed CA(PEG)4, were synthesized by anionic polymerization. Size exclusion chromatography indicated narrow mass distributions and hydrodynamic radii less than 2 nm were calculated. The effects of CA(PEG)4 on human RBC aggregation and blood viscosity were investigated and compared to linear PEGs by light transmission aggregometry. Results showed optimal reduction of RBC aggregation for molar masses between 10–16 kDa of star-shaped CA(PEG)4 polymers. Cholic acid based PEG polymers affect the rheology of erythrocytes and may find applications as alternatives to linear PEG or Pluronics to improve blood fluidity.

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Diffusion in Aqueous Solutions of Poly(ethylene glycol) at Low Concentrations

Cited by 61 publications

References 18 publications

Relationship between molecular weight of poly(ethylene)glycol and intermolecular interaction of Taka-amylase A monomers

Relationship between molecular weight of poly(ethylene)glycol and intermolecular interaction of Taka-amylase A monomers

Precise measurement of the self-diffusion coefficient for poly(ethylene glycol) in aqueous solution using uniform oligomers

Effects of amphiphilic star-shaped poly(ethylene glycol) polymers with a cholic acid core on human red blood cell aggregation

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