Diffusion-driven fed-batch fermentation in perforated ring flasks
Clara Lüchtrath,
Felix Lamping,
Sven Hansen
et al.
Abstract:Purpose
Simultaneous membrane-based feeding and monitoring of the oxygen transfer rate shall be introduced to the newly established perforated ring flask, which consists of a cylindrical glass flask with an additional perforated inner glass ring, for rapid bioprocess development.
Methods
A 3D-printed adapter was constructed to enable monitoring of the oxygen transfer rate in the perforated ring flasks. Escherichia coli experiments in batch were performed … Show more
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