Diffusion-based tractography in neurological disorders: concepts, applications, and future developments

Ciccarelli, Olga; Catani, Marco; Johansen‐Berg, Heidi; Clark, Christopher A.; Thompson, Alan J.

doi:10.1016/s1474-4422(08)70163-7

Cited by 359 publications

(299 citation statements)

References 121 publications

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“…This barrier is the reason for the high anisotropy of white matter when compared to gray matter, in which the diffusion of water is almost isotropic 13 . There are many ways of measuring anisotropy, but one *P values for bilateral test; GTSD: right superior temporal gyrus; GTMD: right medium temporal gyrus; GTID: right inferior temporal gyrus; GTSE: left superior temporal gyrus; GTME: left medium temporal gyrus; GTIE: left inferior temporal gyrus; GSME: left supramarginal gyrus; GSMD: right supramarginal gyrus.…”

Section: Discussionmentioning

confidence: 99%

Primary progressive aphasia patients evaluated using diffusion tensor imaging and voxel based volumetry-preliminary results

Oliveira

Costa

Marroni

et al. 2011

Arq. Neuro-Psiquiatr.

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There are individuals who have a progressive language deficit without presenting cognitive deficits in other areas. One of the diseases related to this presentation is primary progressive aphasia (PPA). Objective: Identify by means of diffusion tensor imaging (DTI) and measurements of cortical volume, brain areas that lead to dysphasia when presenting signs of impaired connectivity or reduced volume. Method: Four patients with PPA were evaluated using DTI, and measurements of cortical volumes in temporal areas. These patients were compared with two normal volunteers. Results: There is a trend to a difference in the number and volume of related fibers between control group and patients with PPA. Comparing cortical volumes in temporal areas between groups yielded a trend to a smaller volume in PPA patients. Conclusion: Patients with PPA have a trend to impairment in cortical and subcortical levels regarding relevant areas. Key words: anomia, primary progressive aphasia, DTI, tractography, arcuate fasciculus, language Avaliação de pacientes com afasia primária progressiva com imagem tensor de difusão e volumetria baseada em voxels RESUMO Existem indivíduos que apresentam deterioração progressiva da linguagem sem apresentar déficits em outros domínios cognitivos; estes pacientes em geral apresentam afasia primária progressiva (APP). Objetivo: Identificar, pela imagenologia, áreas cerebrais que quando sofrem atrofia, ou quando seu sistema de conexões apresenta alterações, levam a disfasia. Método: Foram avaliados quatro pacientes com APP, utilizando-se ressonância magnética com as técnicas de imagem por tensores da difusão (DTI) e medida do volume cortical em áreas de interesse previamente definidas. Estes pacientes foram comparados com um grupo controle constituído por dois voluntários. Resultados: Redução da média dos volumes dos giros temporais esquerdos no grupo de pacientes, em relação ao grupo controle, e alterações quanto ao volume e número de fibras nos tratos correspondentes. Conclusão: Pacientes com APP têm tendência a apresentar danos tanto ao nível cortical quanto subcortical. Palavras-chave: anomia, afasia primária progressiva, DTI, tratografia, volume cerebral, fascículo arqueado, linguagem. Correspondence Fábio Pascotto de Oliveira

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Section: Discussionmentioning

confidence: 99%

Primary progressive aphasia patients evaluated using diffusion tensor imaging and voxel based volumetry-preliminary results

Oliveira

Costa

Marroni

et al. 2011

Arq. Neuro-Psiquiatr.

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“…Based on animal studies, it is generally accepted that the degree of axon packing and myelin sheaths are the main features that cause water diffusion to be anisotropic (Beaulieu, 2002). As a noninvasive marker of white matter pathology, DTI has tremendous potential and has been extensively used to infer the micro-structural characteristics of brain tissue in a myriad of human conditions, including normal development and aging, and neurological and psychiatric disorders (Johansen-Berg and Behrens, 2006;Ciccarelli et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

In VivoDiffusion Tensor Imaging and Histopathology of the Fimbria-Fornix in Temporal Lobe Epilepsy

Concha¹,

Livy²,

Beaulieu³

et al. 2010

J. Neurosci.

198

165

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While diffusion tensor imaging (DTI) has been extensively used to infer micro-structural characteristics of cerebral white matter in human conditions, correlations between human in vivo DTI and histology have not been performed. Temporal lobe epilepsy (TLE) patients with mesial temporal sclerosis (MTS) have abnormal DTI parameters of the fimbria-fornix (relative to TLE patients without MTS) which are presumed to represent differences in axonal/myelin integrity. Medically intractable TLE patients who undergo temporal lobe resection including the fimbria-fornix provide a unique opportunity to study the anatomical correlates of water diffusion abnormalities in freshly excised tissue. Eleven patients with medically intractable TLE were recruited (six with and five without MTS) for presurgical DTI followed by surgical excision of a small specimen of the fimbria-fornix which was processed for electron microscopy. Blinded quantitative analysis of the microphotographs included axonal diameter, density and area, cumulative axon membrane circumference, and myelin thickness and area. As predicted by DTI the fimbria-fornix of TLE patients with MTS had increased extra-axonal fraction, and reduced cumulative axonal membrane circumference and myelin area. Consistent with the animal literature, water diffusion anisotropy over the crus of the fimbria-fornix was strongly correlated with axonal membranes (cumulative membrane circumference) within the surgical specimen (ϳ15% of what was analyzed with DTI). The demonstration of a correlation between histology and human in vivo DTI, in combination with the observation that in vivo DTI accurately predicted white matter abnormalities in a human disease condition, provides strong validation of the application of DTI as a noninvasive marker of white matter pathology.

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“…MD can also be divided into axial diffusivity (AD), the magnitude of diffusion along the principal direction of diffusion, and radial diffusivity (RD), or the average magnitude of diffusion along the two perpendicular directions of diffusion. These metrics may provide additional information related to demyelination [89] and axonal damage [90]. There are two main approaches to analyse diffusion data: a voxel-based approach using regions-of-interest (ROIs) or whole-brain data, or tractography (Figure 6), where reconstruction of major white matter tracts can be performed by following the continuity and direction of maximum diffusion from contiguous voxels [91].…”

Section: Diffusion Tensor Imagingmentioning

confidence: 99%

Neurological Complications and MRI

Kawadler¹,

Kirkham²

2016

Sickle Cell Disease - Pain and Common Chronic Complications

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Cerebrovascular diseases (cerebral infarction, intracranial haemorrhage and vasculopathy) are common manifestations of sickle cell disease (SCD) associated with significant morbidity and mortality. These neurological complications and potential corresponding neuropsychological compromise may have devastating consequences for a child with SCD. This chapter aims to review the neurological complications in SCD using magnetic resonance imaging (MRI) as both a qualitative and a quantitative tool for detecting abnormality. Advanced MRI pulse sequences, such as high-resolution 3D T1-weighted imaging for brain volumetrics, diffusion tensor imaging for white matter integrity and non-invasive perfusion MRI for cerebral blood flow (CBF) measurement, can provide additional information about the structure and function of brain tissue beyond the scope of conventional clinical imaging. These studies have set to establish quantitative biomarkers that relate to disease severity and neuropsychological sequelae.

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Diffusion-based tractography in neurological disorders: concepts, applications, and future developments

Cited by 359 publications

References 121 publications

Primary progressive aphasia patients evaluated using diffusion tensor imaging and voxel based volumetry-preliminary results

Primary progressive aphasia patients evaluated using diffusion tensor imaging and voxel based volumetry-preliminary results

In VivoDiffusion Tensor Imaging and Histopathology of the Fimbria-Fornix in Temporal Lobe Epilepsy

Neurological Complications and MRI

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