Diffusion and Controlled Release in Physically Crosslinked Poly (Vinyl Alcohol)/Iota-Carrageenan Hydrogel Blends

Croitoru, Cătălin; Roată, Ionuţ Claudiu; Pascu, Alexandru; Stanciu, Elena Manuela

doi:10.3390/polym12071544

Cited by 27 publications

(11 citation statements)

References 69 publications

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“…The weakly basic conjugated phenolic enone system was reported to take place at pH = 7.3 which could account for a 25% increase in the value of the tetracycline diffusion coefficients, compared to pH = 3. It has been revealed that amino groups turn out to be ionized only at pH > 8, which is well outside the pH thresholds for the human body [ 54 ]. After the TC release for 2 days, as demonstrated in Figure 11 E,F, E-CMC-CEL showed highest amount of tetracycline release at 5.06 mg g −1 dry gel, followed by E-CMC which was released at 4.37 mg g −1 dry gel.…”

Section: Resultsmentioning

confidence: 99%

Cryo-Induced Cellulose-Based Nanogel from Elaeis guineensis for Antibiotic Delivery Platform

Hajidariyor

Nuntawad

Somsaen

et al. 2023

IJMS

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Cryo-induced hydrogel from cellulose is a new class of biomaterials for drug delivery, cell delivery, bone and skin tissue engineering for cell proliferation and regeneration applications. This research aimed to synthesize cryo-induced hydrogel from cellulose and carboxymethyl cellulose (CMC) produced from empty bunch’s cell wall of Elaeis guineensis. First, the experiment was to produce cellulose-rich material using hot-compressed water extraction followed by alkaline delignification and bleaching with H2O2. The obtained bleached EFB cellulose was used as the substrate for CMC, and the optimal condition with the highest degree of carboxyl substitution (DS) of 0.75 was achieved when varying NaOH and monochloroacetic acid concentration as well as etherification temperature using fractional factorial design. For cryogelation study, hydrogels were synthesized from cellulose, CMC and beta-cyclodextrin (β-CD) by dissolving cellulose-based matrix in a NaOH/urea system, and the cellulose (CEL) solution was frozen spontaneously at −40 °C followed by high speed mixing to loosen cellulose fibrils. Epichlorohydrin (ECH) and Polyethylene glycol diglycidyl ether (PEGDE) were used as a cross-linker. First, the ratio of cellulose and CMC with different amounts of ECH was investigated, and subsequently the proper ratio was further studied by adding different crosslinkers and matrices, i.e., CMC and β-CD. From the result, the ECH crosslinked CMC-CEL (E-CMC-CEL) gel had the highest swelling properties of 5105% with the average pore size of lyophilized hydrogel of 300 µm. In addition, E-CMC-CEL gel had the highest loading and release capability of tetracycline in buffer solution at pH 7.4 and 3.2. At pH 7.4, tetracycline loading and release properties of E-CMC-CEL gel were 65.85 mg g−1 dry hydrogel and 46.48 mg g−1 dry hydrogel (70.6% cumulative release), respectively. However, at pH 3.2, the loading and release capabilities of Tetracycline were moderately lower at 16.25 mg g−1 dry hydrogel and 5.06 mg g−1 dry hydrogel, respectively. The findings presented that E-CMC-CEL hydrogel was a suitable material for antibiotic tetracycline drug carrying platform providing successful inhibitory effect on Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, respectively.

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Section: Resultsmentioning

confidence: 99%

Cryo-Induced Cellulose-Based Nanogel from Elaeis guineensis for Antibiotic Delivery Platform

Hajidariyor

Nuntawad

Somsaen

et al. 2023

IJMS

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“…Carrageenan is presented as a gold candidate in pharmaceutical and biotechnological applications because of its biocompatibility, high viscosity, and gelling capacity, and the ability for its controlled release of drugs [ 9 , 34 , 116 ]. However, the fast degeneration and quick swelling of carrageenan cause the fast release of drugs with less effectivity [ 117 ]. In this regard, the interaction of different types of carrageenan with each other or other polymers is helpful to achieve ideal drug release platforms [ 118 ].…”

Section: Hybrid Carrageenan-based Platforms and Its Applicationmentioning

confidence: 99%

Recent Advances in Chemically-Modified and Hybrid Carrageenan-Based Platforms for Drug Delivery, Wound Healing, and Tissue Engineering

et al. 2021

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Recently, many studies have focused on carrageenan-based hydrogels for biomedical applications thanks to their intrinsic properties, including biodegradability, biocompatibility, resembling native glycosaminoglycans, antioxidants, antitumor, immunomodulatory, and anticoagulant properties. They can easily change to three-dimensional hydrogels using a simple ionic crosslinking process. However, there are some limitations, including the uncontrollable exchange of ions and the formation of a brittle hydrogel, which can be overcome via simple chemical modifications of polymer networks to form chemically crosslinked hydrogels with significant mechanical properties and a controlled degradation rate. Additionally, the incorporation of various types of nanoparticles and polymer networks into carrageenan hydrogels has resulted in the formation of hybrid platforms with significant mechanical, chemical and biological properties, making them suitable biomaterials for drug delivery (DD), tissue engineering (TE), and wound healing applications. Herein, we aim to overview the recent advances in various chemical modification approaches and hybrid carrageenan-based platforms for tissue engineering and drug delivery applications.

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“…111) However, there are some controlling factors like swelling force, mechanical strength, diffusion release (matrix or reservoir system), and viscosity that need to be considered to release the drug from the matrix. 3,[112][113][114][115] Ulvan has been modified with lysozyme that has cationic charged. The complex formation results in stable nanoparticles and increasing antibacterial activity.…”

Section: Drug Deliverymentioning

confidence: 99%

A Comprehensive Review on Ulvan Based Hydrogel and Its Biomedical Applications

et al. 2021

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Diffusion and Controlled Release in Physically Crosslinked Poly (Vinyl Alcohol)/Iota-Carrageenan Hydrogel Blends

Cited by 27 publications

References 69 publications

Cryo-Induced Cellulose-Based Nanogel from Elaeis guineensis for Antibiotic Delivery Platform

Cryo-Induced Cellulose-Based Nanogel from Elaeis guineensis for Antibiotic Delivery Platform

Recent Advances in Chemically-Modified and Hybrid Carrageenan-Based Platforms for Drug Delivery, Wound Healing, and Tissue Engineering

A Comprehensive Review on Ulvan Based Hydrogel and Its Biomedical Applications

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