Diffusion analysis of fluid dynamics with incremental strength of motion proving gradient (DANDYISM) to evaluate cerebrospinal fluid dynamics

Taoka, Toshiaki; Kawai, Hisashi; Nakane, Toshiki; Abe, Takashi; Nakamichi, Rei; Ito, Rintaro; Sato, Yuki; Sakai, Mayuko; Naganawa, Shinji

doi:10.1007/s11604-020-01075-4

Cited by 17 publications

(25 citation statements)

References 19 publications

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“…The theory of estimating diffusion properties from different levels of diffusion weightings has been well characterized 30 and the approach proposed here is similar to a calculation of the apparent diffusion coe cient, albeit over a range of diffusion weightings relevant to CSF motion. Recent work has applied DWI at different b-values to qualitatively estimate neuro uid motion from categorical scoring of the rate of decay in ten healthy adults (aged = 25-58 years) in posterior fossa, suprasellar cistern, and Sylvian vallecula compared to the lateral ventricle and frontal and parietal CSF spaces 11 . This work also provided support for greater CSF uid motion in the third ventricles in younger versus older participants, however, the method required radiological scoring and non-continuous, quantitative assessment was not proposed.…”

Section: Expansion Of Methodologies To Assess Uid Movement Non-invasi...mentioning

confidence: 99%

“…To begin to address this limitation, we implemented a novel diffusion weighted imaging (DWI) magnetic resonance imaging (MRI) protocol and analysis approach, which incorporates dynamic diffusion weighting cycling over the approximate kinetic range of CSF motion within the suprasellar cistern. This approach, which has previously been proposed in healthy adults using categorical scoring of signal attenuation for increasing diffusion weighting 11 , is applied here to (i) demonstrate sensitivity to regions with known differences in neuro uid motion and (ii) quantify relationships between neuro uid motion and choroid plexus perfusion in older adults with and without PD. The hypothesis to be investigated is that neuro uid motion within the suprasellar cistern of patients with PD is reduced relative to agematched controls.…”

Section: Introductionmentioning

confidence: 99%

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Reduced suprasellar cistern cerebrospinal fluid motion in patients with Parkinson’s disease revealed by magnetic resonance imaging with dynamic cycling of diffusion weightings

Mays,

Hett,

Eisma

et al. 2023

Preprint

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BACKGROUND: Parkinson’s disease is characterized by dopamine-responsive symptoms as well as aggregation and accumulation of a-synuclein protofibrils. New diagnostic methods assess a-synuclein aggregation characteristics from cerebrospinal fluid and recent pathophysiologic mechanisms suggest that cerebrospinal fluid circulation disruptions may precipitate a-synuclein retention. Here, we test the hypothesis that cerebrospinal fluid motion at the level of the suprasellar cistern is reduced in Parkinson’s disease relative to healthy participants and this reduction relates to choroid plexus perfusion. METHODS: Diffusion weighted imaging (spatial resolution=1.8x1.8x4 mm) magnetic resonance imaging with cycling of diffusion weightings (b-values=0, 50, 100, 200, 300, 700, and 1000 s/mm2) over the approximate kinetic range of suprasellar cistern neurofluid motion was applied at 3-Tesla in Parkinson’s disease (n=27; age=66±6.7 years) and healthy (n=32; age=68±8.9 years) participants. Wilcoxon rank-sum tests were applied to test the primary hypothesis that the decay rate of cerebrospinal fluid signal as a function of b-value, which reflects increasing fluid motion, is reduced in persons with versus without Parkinson’s disease and inversely relates to choroid plexus activity assessed from perfusion-weighted magnetic resonance imaging (Spearman rank-order correlation; significance-criteria: p<0.05). RESULTS: Consistent with the primary hypothesis, decay rates were higher in healthy (D=0.00328±0.00123mm2/s) relative to Parkinson’s disease (D=0.00256±0.0094mm2/s) participants (p=0.016). This finding was preserved after controlling for age and sex. An inverse correlation between choroid plexus perfusion and decay rate (p=0.011) was observed in Parkinson’s disease participants. CONCLUSIONS: Cerebrospinal fluid motion at the level of the suprasellar cistern is often reduced in adults with versus without Parkinson’s disease and this reduction correlates on average with choroid plexus perfusion.

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Section: Expansion Of Methodologies To Assess Uid Movement Non-invasi...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Reduced suprasellar cistern cerebrospinal fluid motion in patients with Parkinson’s disease revealed by magnetic resonance imaging with dynamic cycling of diffusion weightings

Mays,

Hett,

Eisma

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Epub ahead of print brain with 16,17,19,27,33,39,40 and without IV-GBCA. [41][42][43][44][45][46][47] The significance of the PML-PSS might be evaluated in a future study combined with previously proposed methods.…”

Section: Meningeal Lymphatics Along Sigmoid Sinusmentioning

confidence: 99%

Association between the Putative Meningeal Lymphatics at the Posterior Wall of the Sigmoid Sinus and Delayed Contrast-agent Elimination from the Cerebrospinal Fluid

et al. 2024

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To investigate the characteristics of the putative meningeal lymphatics located at the posterior wall of the sigmoid sinus (PML-PSS) in human subjects imaged before and after intravenous administration (IV) of a gadolinium-based contrast agent (GBCA). The appearance of the PML-PSS and the enhancement of the perivascular space of the basal ganglia (PVS-BG) were analyzed for an association with gender, age, and clearance of the GBCA from the cerebrospinal fluid (CSF).Methods: Forty-two patients with suspected endolymphatic hydrops were included. Heavily T2-weighted 3D-fluid attenuated inversion recovery (hT2w-3D-FLAIR) and 3D-real inversion recovery (IR) images were obtained at pre-administration, immediately post-administration, and at 4 and 24 hours after IV-GBCA. The appearance of the PML-PSS and the presence of enhancement in the PVS-BG were analyzed for a relationship with age, gender, contrast enhancement of the CSF at 4 hours after IV-GBCA, and the washout ratio of the GBCA in the CSF from 4 to 24 hours after IV-GBCA. Results:The PML-PSS and PVS-BG were seen in 23 of 42 and 21 of 42 cases, respectively, at 4 hours after IV-GBCA. In all PML-PSS positive cases, hT2w-3D-FLAIR signal enhancement was highest at 4 hours after IV-GBCA. A multivariate analysis between gender, age, CSF signal elevation at 4 hours, and washout ratio indicated that only the washout ratio was independently associated with the enhancement of the PML-PSS or PVS-BG. The odds ratios (95% CIs; P value) were 4.

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“…Low b-value diffusion imaging is a simple method to observe CSF dynamics over a large area in a short time. Diffusion-weighted images with low b-values such as b = 500 s/mm 2 can evaluate CSF dynamics as the stationary CSF signal remains to some extent, and the signal decrease reflects the magnitude of the water movement 34,35 . Even with this simple method, there is almost no signal reduction in the bilateral lateral ventricles, including the region surrounding the choroid plexus.…”

Section: Cerebrospinal Fluid Production and Dynamicsmentioning

confidence: 99%

The Glymphatic System in Humans: Investigations With Magnetic Resonance Imaging

Naganawa¹,

Taoka

Ito

et al. 2023

Invest Radiol

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The concept of the glymphatic system was proposed more than a decade ago as a mechanism for interstitial fluid flow and waste removal in the central nervous system. The function of the glymphatic system has been shown to be particularly activated during sleep. Dysfunction of the glymphatic system has been implicated in several neurodegenerative diseases. Noninvasive in vivo imaging of the glymphatic system is expected to be useful in elucidating the pathophysiology of these diseases. Currently, magnetic resonance imaging is the most commonly used technique to evaluate the glymphatic system in humans, and a large number of studies have been reported. This review provides a comprehensive overview of investigations of the human glymphatic system function using magnetic resonance imaging. The studies can be divided into 3 categories, including imaging without gadolinium-based contrast agents (GBCAs), imaging with intrathecal administration of GBCAs, and imaging with intravenous administration of GBCAs. The purpose of these studies has been to examine not only the interstitial fluid movement in the brain parenchyma, but also the fluid dynamics in the perivascular and subarachnoid spaces, as well as the parasagittal dura and meningeal lymphatics. Recent research has even extended to include the glymphatic system of the eye and the inner ear. This review serves as an important update and a useful guide for future research directions.

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Diffusion analysis of fluid dynamics with incremental strength of motion proving gradient (DANDYISM) to evaluate cerebrospinal fluid dynamics

Cited by 17 publications

References 19 publications

Reduced suprasellar cistern cerebrospinal fluid motion in patients with Parkinson’s disease revealed by magnetic resonance imaging with dynamic cycling of diffusion weightings

Reduced suprasellar cistern cerebrospinal fluid motion in patients with Parkinson’s disease revealed by magnetic resonance imaging with dynamic cycling of diffusion weightings

Association between the Putative Meningeal Lymphatics at the Posterior Wall of the Sigmoid Sinus and Delayed Contrast-agent Elimination from the Cerebrospinal Fluid

The Glymphatic System in Humans: Investigations With Magnetic Resonance Imaging

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