Diffuse Uterine Adenomatoid Tumor in a Patient With Chronic Hepatitis C Virus Infection

Açıkalın, Mustafa Fuat; Tanir, H. Mete; Özalp, Sinan; Dündar, Emine; Çiftçi, Evrim; Özalp, Emel

doi:10.1111/igc.0b013e31819bc8f9

Cited by 10 publications

(12 citation statements)

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“…Genetically, the adenomatoid tumor is reported to be a TRAF7 mutation that drives aberrant NF‐kB pathway activation, unlike malignant mesothelioma 8 . Almost all adenomatoid tumors are solitary; only a few case reports have described multiple adenomatoid tumors occurring exclusively outside the genital tract 9–11 . There is no case report of >10 tumors with adenomatoid tumor, as in our patient's case.…”

Section: Discussionmentioning

confidence: 61%

Peritoneal adenomatoid (microcystic) mesothelioma

Mori

Kido

Hiraki

et al. 2020

Pathology International

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There are several reports of pleural adenomatoid (microcystic) mesothelioma, but peritoneal adenomatoid mesothelioma is extremely rare. A 64‐year‐old Japanese woman presented with no symptoms and no asbestos exposure history. An abdominal computed tomography scan revealed multiple hypervascular masses on the liver surface, pelvic cavity and anterior peritoneum. Over 10 pieces of the multiple resected tumors showed numerous microcysts composed of a bland mesothelial cell background with rich capillary vessels. Focally, atypical cells with bizarre nuclei with prominent nucleoli were observed. Adenomatoid mesothelioma was suspected based on histochemical, immunohistochemical and fluorescence in situ hybridization findings. The tumors relapsed 4 years later and metastasized to the lung, but the patient remains alive 7 years after the first tumor resection surgery. Although the prognosis of adenomatoid mesothelioma of pleural origin is poor, the progression of this peritoneal case is slow.

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Section: Discussionmentioning

confidence: 61%

Peritoneal adenomatoid (microcystic) mesothelioma

Mori

Kido

Hiraki

et al. 2020

Pathology International

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“…There was no recurrence, malign transformation or matastasis reported in the follow-up of the patients with adenomatoid tumors. It was also suggested that it may be related to immunosupresive conditions like hapatitis C (15) or renal tranplant (16,17). Our patient was also asymptomatic and the diagnosis of adenomatoid tumor was done by the pathologic examination.…”

Section: Discussionmentioning

confidence: 99%

Xanthogranulomatous inflammation of the ovary with the uterine adenomatoid tumor in a patient with diabetes mellitus: A case report

et al. 2018

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Adenomatoid tumor of the uterus and xanthogranulomatous inflammation of the ovary are very rare lesions. This case report is to document both lesions in a patient with diabetes mellitus. A postmenopausal patient, ultrasonographic examination revealed 72*42mm cystic lesion in adnexial region and 120*40mm sized collection of intraabdominal fluid .The patient had diabetes mellitus for 6 years. Total abdominal hysterectomy and bilateral salphingooferectomy were performed. The pathology report came out as uterin adenomatoid tumor, ovarian xanthogranulomatous inflammation, abcess formation in the same fallopian tube. This is the first reported case, both lesions in the same patient. Immunesupression is the common etiologic factor for both lesions. Uncontrolled diabetes mellitus resulting in impaired leukocyte function and immunocompromised status may be predisposing factors. Preoperative diagnosis of both adenomatoid tumor and xantogranulamatous inflammation may be important in avoiding aggressive surgical intervention but mostly the exact diagnosis can only be made by pathologic examination.

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“…Los TA generalmente son nodulares, sin embargo, se han descrito casos difusos que infiltran prácticamente todo el miometrio. En la mitad de los reportes que hay en la literatura, estos últimos corresponden a casos en pacientes inmunodeprimidos (2,(21)(22)(23). Algunos autores creen que la variedad difusa podría corresponder a una entidad biológica distinta (24).…”

Section: Discussionunclassified

“…Este término fue utilizado por primera vez en 1945 por Golden y Ash (1). Se trata de tumores que suelen ser únicos, afectando mayoritariamente al aparato reproductor femenino, y principalmente al útero durante la edad reproductiva (2)(3)(4). También pueden encontrarse en el aparato genital masculino (5), glándula suprarrenal, linfonodos, mediastino, corazón, páncreas y pleura (6)(7)(8)(9).…”

Section: Introductionunclassified

Tumores Adenomatoides Uterinos: Estudio Anatomo-Patológico E Inmunohistoquímico De 32 Casos

et al. 2009

Rev. chil. obstet. ginecol.

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RESUMENAntecedentes: Los tumores adenomatoides (TA) son poco frecuentes. Se encuentran principalmente en el aparato reproductor femenino y especialmente en el útero. No existen reportes a nivel nacional sobre estos. Objetivos: Describir las características histológicas e inmunohistoquímicas de los TA uterinos. Método: Estudio descriptivo de 32 muestras ingresadas al Servicio de Anatomía Patológica de Clínica Las Condes. Las muestras estudiadas fueron recopiladas entre noviembre de 1999 y noviembre de 2008. Resultados: El diagnóstico de TA fue realizado en 21 histerectomías y 11 miomectomías. En 14 casos se diagnosticaron como lesiones nodulares únicas (43,8%) y en 18 junto a leiomiomas (56,2%). El tamaño promedio de las lesiones únicas fue 2,6 cm, significativamente mayor que aquellas asociadas a leiomiomas. El patrón histológico predominante más frecuente correspondió al tipo angiomatoide (81,3%), seguido por los patrones adenoide (9,4%), sólido (6,3%) y mixto (3%), no se encontraron TA quísticos. El estudio inmunohistoquími-co fue positivo en el 100% de los casos para citoqueratina AE1/AE3, calrretinina, vimentina y D2-40. Fue negativo para CD31 y CEA. Sólo un 6,3% (2 casos) fue positivo para citoqueratina 5/6. Conclusiones: Los TA corresponden a tumores benignos de origen mesotelial. Generalmente su diagnóstico es un hallazgo. Al presentarse en el útero, se confunden generalmente con leiomiomas o se presentan en conjunto con estos. En base a lo anterior el tratamiento de estas lesiones debe ser conservador, bastando con la resección del tumor.PALABRAS CLAVE: Tumor adenomatoide uterino, tumor benigno uterino, inmunohistoquímica, tumor mesotelial SUMMARY Background:The adenomatoid tumors (AT) are rare. They are found mainly in the female reproductive system and especially in the uterus. There is not national reporting on these. Objective: To describe the histological and immunohistochemical features of uterine AT. Method: Descriptive study of 32 patients admitted to the Pathology Department of Clínica Las Condes. The cases studied were collected between November 1999 and November 2008. Results: The diagnosis of AT was performed in 21 hysterectomies and 11 myomectomies. In 14 patients were diagnosed as nodular single lesions (43.8%) and in 18 cases associated with leiomyomas (56.2%), the average size of single lesions was 2.6 cm, significantly greater than those associated with leiomyomas. The predominant histologic type most often correspond to angiomatoid (81.3%), followed by adenoid patterns (9.4%), solid (6.3%) and mixed (3%), the cystic pattern was not observed. The

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Diffuse Uterine Adenomatoid Tumor in a Patient With Chronic Hepatitis C Virus Infection

Cited by 10 publications

References 9 publications

Peritoneal adenomatoid (microcystic) mesothelioma

Peritoneal adenomatoid (microcystic) mesothelioma

Xanthogranulomatous inflammation of the ovary with the uterine adenomatoid tumor in a patient with diabetes mellitus: A case report

Tumores Adenomatoides Uterinos: Estudio Anatomo-Patológico E Inmunohistoquímico De 32 Casos

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