Diffuse-type giant cell tumor of the subcutaneous thigh

Sanghvi, Darshana; Purandare, N.; Jambhekar, Nirmala A.; Agarwal, Manish; Agarwal, Aditi

doi:10.1007/s00256-006-0112-6

Cited by 17 publications

(9 citation statements)

References 6 publications

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“…The next most common site of localized extraarticular disease is the foot and ankle, which account for 5%-15% of lesions (5)(6)(7)12). Rare sites of PVNTS include the knee, hip, elbow, and shoulder (22,23). PVNB most commonly occurs about the hip or knee in our experience.…”

Section: Clinical Characteristicsmentioning

confidence: 55%

Pigmented Villonodular Synovitis: Radiologic-Pathologic Correlation

Rhee²,

et al. 2008

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Pigmented villonodular synovitis (PVNS) represents an uncommon benign neoplastic process that may involve the synovium of the joint diffusely or focally (PVNS) or that may occur extraarticularly in a bursa (pigmented villonodular bursitis [PVNB]) or tendon sheath (pigmented villonodular tenosynovitis [PVNTS]). Pathologic specimens of the hypertrophic synovium may appear villous, nodular, or villonodular, and hemosiderin deposition, often prominent, is seen in most cases. The knee, followed by the hip, is the most common location for PVNS or PVNB, whereas PVNTS occurs most often in the hand and foot. PVNTS is also referred to as giant cell tumor of the tendon sheath (GCTTS). PVNTS is the most common form of this disease by a ratio of approximately 3:1. Radiographs reveal nonspecific features of a joint effusion in PVNS, a focal soft-tissue mass in PVNB or PVNTS, or a normal appearance. Extrinsic erosion of bone (on both sides of the joint) may also be seen and is most frequent with intraarticular involvement of the hip (>90% of cases). Cross-sectional imaging reveals diffuse involvement of the synovium (PVNS), an intimate relationship to the tendon (PVTNS), or a typical bursal location (PVNB), findings that suggest the diagnosis. However, the magnetic resonance (MR) imaging findings of prominent low signal intensity (seen with T2-weighting) and "blooming" artifact from the hemosiderin (seen with gradient-echo sequences) are nearly pathognomonic of this diagnosis. In addition, MR imaging is optimal for evaluating lesion extent. This information is crucial to guide treatment and to achieve complete surgical resection. Recurrence is more common with diffuse intraarticular disease and is difficult to distinguish, both pathologically and radiologically, from the rare complication of malignant PVNS. Recognizing the appearances of the various types of PVNS, which reflect their pathologic characteristics, improves radiologic assessment and is important for optimal patient management.

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Section: Clinical Characteristicsmentioning

confidence: 55%

Pigmented Villonodular Synovitis: Radiologic-Pathologic Correlation

Rhee²,

et al. 2008

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“…Because extra-articular diffuse-type GCTs are rare, the differential diagnosis is challenging. Our pre-operative differential diagnosis included soft-tissue sarcoma and desmoid tumor [9] .…”

Section: Discussionmentioning

confidence: 99%

Giant cell tumor of soft tissues: A case report of extra-articular diffuse-type giant cell tumor of the quadriceps

Rateb¹,

Hassen²,

Abid³

et al. 2017

International Journal of Surgery Case Reports

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“…This tumor was once regarded as a non-neoplastic condition, but their potential for recurrence and metastasis suggested the possibilities of neoplastic nature [ 5 , 7 ]. Furthermore, the cytogenetic studies identified clonal abnormalities, which suggested that this tumor was indeed a neoplasm [ 5 ].…”

Section: Discussionmentioning

confidence: 99%