Diffuse spinal spreading following previous intracranial intradural chordoma resection: A rare case report

Vellutini, Eduardo de Arnaldo Silva; Brock, Roger Schmidt; Martins, Henrique Oliveira; Taricco, Mario Augusto; Oliveira, Matheus Fernandes de

doi:10.1016/j.jocn.2019.03.020

Cited by 4 publications

(10 citation statements)

References 8 publications

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“…Maximal surgical resection and local high-dosage radiation have become the primary treatment course, as there is poor response to other treatment strategies. [1][2][3][4][5] Spontaneous regression of clival chordomas had never been described to the best of our knowledge, until Bander et al 1 published a recent case report, followed by Passeri et al 3 We present here what we believe to be the third case report of spontaneous regression of a clival chordoma and discuss similarities of cases and implications for clinical practice.…”

Section: Introductionmentioning

confidence: 57%

“…Chordomas are rare, locally aggressive neoplasms of notochordal origin, constituting 2 to 4% of primary bone tumors. [1][2][3][4][5] They characteristically tend to recur.…”

Section: Discussionmentioning

confidence: 99%

“…Chordoma is a malignant and aggressive tumor originating from remnants of the primitive notochord and usually involving the axial skeleton. [1][2][3][4][5] It has an incidence of approximately 35% in the clivus and 50% in the sacrococcygeal region. Chordomas account for 1% of all primary brain tumors.…”

Section: Introductionmentioning

confidence: 99%

“…Natural history of chordoma is characterized by local growth and invasion and propensity to recur. [1][2][3][4][5] For clival chordomas, symptom onset is insidious and includes diplopia associated with cranial nerve palsies and headache. Maximal surgical resection and local high-dosage radiation have become the primary treatment course, as there is poor response to other treatment strategies.…”

Section: Introductionmentioning

confidence: 99%

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Spontaneous Regression of a Clival Chordoma: An Unusual Case Report

Vellutini

Stamm

Oliveira

2021

J Neurol Surg A Cent Eur Neurosurg

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Introduction Chordoma is a malignant and aggressive tumor originating from remnants of the primitive notochord and usually involving the axial skeleton. Spontaneous regression of clival chordomas was described recently. We present the third case report of spontaneous regression of a clival chordoma and discuss similarities of cases and implications for clinical practice. Case Description We present the case of a previously healthy 21-year-old Caucasian woman who presented with progressive holocranial headache for 3 months, which encouraged image investigation. Magnetic resonance imaging (MRI) revealed an osteolytic clival lesion hyperintense in T2 and hypointense in T1 images. After 2 months of initial evaluation and surgical proposal, she repeated MRI to allow use for intraoperative neuronavigation. Surprisingly, there was tumor regression. Discussion The present reported case is somehow different from previous ones and does not share an underlying inflammatory/immunological recognizable fact, being interpreted by us as a spontaneous partial regression of the tumor. We highlight the need for continuous investigation of chordoma regression to uncover the underlying mechanisms.

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Section: Introductionmentioning

confidence: 57%

“…Chordomas are rare, locally aggressive neoplasms of notochordal origin, constituting 2 to 4% of primary bone tumors. [1][2][3][4][5] They characteristically tend to recur.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Spontaneous Regression of a Clival Chordoma: An Unusual Case Report

Vellutini

Stamm

Oliveira

2021

J Neurol Surg A Cent Eur Neurosurg

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“…In addition, the epidemiology of chordoma is unclear (9), particularly as regards its incidence rates and the most frequently affected parts of the axial skeleton (10,11). This is clinically significant, since the symptoms and treatment strategies of chordoma largely depend on its anatomical location (12,13).…”

Section: Discussionmentioning

confidence: 99%

Sacral and thoracic chordoma with pulmonary metastases: A case report and review of the literature

et al. 2020

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Chordoma is a sporadic type of cancer that affects the spine and is particularly challenging to treat due to the paucity of reported cases and scientific literature. In particular, primary chordomas affecting both the sacral and thoracic vertebrae are extremely rare. We herein report a rare case of chordoma in the sacral and thoracic vertebrae with pulmonary metastasis, along with a literature review. The objective of the present study was to explore treatment options and long-term outcomes in patients with metastatic chordoma. Posterior decompression was performed for the thoracic tumor, followed by extended resection of the sacral tumor. The symptoms of the patient were relieved after surgery, and the postoperative Nurick score decreased from grade 3 to grade 2, while the postoperative McCormick score was I. Therefore, complete chordoma excision and internal spinal fixation may effectively reduce tumor recurrence and metastasis.

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Nonenhancing intracranial intradural chordoma mimicking an epidermoid cyst on magnetic resonance imaging: a case report

Almeida

Januário

Carvalho

2021

Radiology Case Reports

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Chordomas are relatively rare malignant tumors derived from embryonic notochord remnants. Most intracranial chordomas show extradural extension and cause bone erosion. However, a small percentage of these tumors are exclusively intradural and tend to show less aggressive features, although local recurrence and metastatic spread have been described. Intradural chordomas with imaging features similar to epidermoid cysts are exceedingly rare. We describe the case of a nonenhancing and nondestructive intradural prepontine chordoma showing restricted diffusion on magnetic resonance imaging on a 44-year-old man who presented with acute-onset vertigo and vomiting. Subtotal resection of the lesion was performed followed by adjuvant radiation therapy. Histopathological examination revealed a chordoma. This case report highlights the need to include intradural chordomas in the differential diagnosis of a nonenhancing and nondestructive prepontine intradural lesion demonstrating restricted diffusion. Gross total resection, adjuvant radiation therapy in cases of macro/microscopical residual disease and regular follow-up imaging assessment are warranted due to the possibility of local recurrence and metastatic dissemination.

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Diffuse spinal spreading following previous intracranial intradural chordoma resection: A rare case report

Cited by 4 publications

References 8 publications

Spontaneous Regression of a Clival Chordoma: An Unusual Case Report

Spontaneous Regression of a Clival Chordoma: An Unusual Case Report

Sacral and thoracic chordoma with pulmonary metastases: A case report and review of the literature

Nonenhancing intracranial intradural chordoma mimicking an epidermoid cyst on magnetic resonance imaging: a case report

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