Diffuse scalp malignant peripheral nerve sheath tumor with intracranial extension in a patient with neurofibromatosis type 1

Ge, Pengfei; Fu, Shuanglin; Lu, Lan; Zhong, Yi; Qi, Bin; Luo, Yunfeng

doi:10.1016/j.jocn.2010.01.055

Cited by 12 publications

(10 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Primary scalp MPNST is extremely rare, with only 14 cases reported to date in English literature (Table 1) [6-18]. MPNST is considered to be associated with gene mutations, such as loss of the neurofibromatosis 1 gene protein product (neurofibroma) [13] and rearrangements of the p16 (INK4A) gene [12,14]. It has been reported that approximately one-third of MPNSTs arise de novo , whereas nearly 60% of all MPNSTs represent a sarcomatous degeneration of a benign neurofibroma.…”

Section: Discussionmentioning

confidence: 99%

Microsurgical management of giant malignant peripheral nerve sheath tumor of the scalp: two case reports and a literature review

Wang

Guo

et al. 2013

World J Surg Onc

View full text Add to dashboard Cite

Malignant peripheral nerve sheath tumors of the scalp are rare lesions of the nervous system. Only 14 cases have been reported to date. The field of neurosurgery has struggled with diagnosing and treating these tumors. In this report, we present two cases of giant malignant peripheral nerve sheath tumors of the scalp and retrospectively analyze the clinical features, imaging findings, pathological features, and prognoses of these two patients. Each underwent microsurgery and radiotherapy. In addition, based on a literature review, we discuss the diagnostic and therapeutic strategies used to treat these unusual lesions.

show abstract

Section: Discussionmentioning

confidence: 99%

Microsurgical management of giant malignant peripheral nerve sheath tumor of the scalp: two case reports and a literature review

Wang

Guo

et al. 2013

World J Surg Onc

View full text Add to dashboard Cite

show abstract

“…Six patients received adjuvant radiotherapy, and one patient with metastatic disease to the kidney and lungs received neoadjuvant chemotherapy with doxorubicin 16 . In three patients, calvarial destruction with intracranial invasion of the tumor was present at the time of diagnosis 11,12,15 . Two of these patients were alive and disease free after follow‐ups of 6 and 28 months, respectively; for the third patient, no follow‐up information was provided.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to classic MPNSTs of deep anatomic origin, which are mostly found on the extremities and trunk, more than half of cutaneous MPNSTs are located on the head and neck 7 . Of those, the majority have been found on the scalp, with a total of 10 reported cases 8–16 …”

mentioning

confidence: 99%

Malignant Peripheral Nerve Sheath Tumor of the Scalp: Case Report and Review of the Literature

Voth

Nakai²,

Wardelmann³

et al. 2011

Dermatologic Surgery

View full text Add to dashboard Cite

show abstract

“…There was no recurrence at 18 months of follow-up (Table 1). The etiology is still uncertain but MPNSTs are commonly associated with Von Recklinghausen disease in whom gene mutations are found, such as loss of the neurofibromatosis 1 gene and rearrangement of the p16 (INK4A) gene (4,5). It has been reported that 60% of all MPNSTs represent a malignant transformation of a preexisting benign neurofibroma, whereas 30% arise de novo, and approximately 10% occur in patients with history of previous radiation at the tumor site.…”

Section: Case Reportmentioning

confidence: 99%

Malignant Schwannoma of the Scalp: A Case Report and Review of the Literature

2018

J Neurol Neurocrit Care

View full text Add to dashboard Cite

Malignant peripheral nerve sheath tumors are uncommon malignant spindle cell tumors that account for 5% to 10% of all soft tissue sarcomas. Localization of such tumors in the scalp is extremely rare. Diagnosing and treating these tumors is very challenging. MethodsCase presentation and Literature review. ResultsWe found 18 cases of malignant peripheral nerve sheath tumors including our case. The occipital region was the most common site of the tumor. Five patients had h intracranial invasion and two patients had distant metastasis. All the patients were treated surgically. Four patients had recurrence of their tumors and two of them died from the disease ConclusionMPNSTs should be considered in the differential diagnosis of rapidly enlarging scalp tumors. Radical excision with wide margins and adjuvant radiation therapy should be considered as the standard treatment for these highly malignant tumors

show abstract

Diffuse scalp malignant peripheral nerve sheath tumor with intracranial extension in a patient with neurofibromatosis type 1

Cited by 12 publications

References 13 publications

Microsurgical management of giant malignant peripheral nerve sheath tumor of the scalp: two case reports and a literature review

Microsurgical management of giant malignant peripheral nerve sheath tumor of the scalp: two case reports and a literature review

Malignant Peripheral Nerve Sheath Tumor of the Scalp: Case Report and Review of the Literature

Malignant Schwannoma of the Scalp: A Case Report and Review of the Literature

Contact Info

Product

Resources

About