Diffuse reflectance spectroscopy of human adenomatous colon polyps in vivo

Zonios, George; Perelman, Lev T.; Backman, Vadim; Manoharan, Ramasamy; Fitzmaurice, Maryann; Dam, Jacques Van; Feld, Michael S.

doi:10.1364/ao.38.006628

Cited by 507 publications

(487 citation statements)

References 34 publications

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“…Zonios et al reported a clinical study in which scattering spectroscopy was used to distinguish adenomatous from hyperplastic colonic polyps. 27 Wallace et al employed scattering spectroscopy in the detection of dysplasia within Barrett's esophagus; 28 and Backman et al reported on development of a method using polarized scattering spectroscopy for quantitative assessment of nuclear size in epithelial cells. 29 Diagnostic Applications in Breast Cancer.…”

Section: Elastic Scattering Spectroscopymentioning

confidence: 99%

Spectrroscopic Sensing of Cancer and Cancer Therapy: Current Status of Translational Research

Bigio

Bown²

2004

Cancer Biology & Therapy

143

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Various types of optical spectroscopy have been investigated as methods to effect a non-invasive, real-time in-situ assessment of tissue pathology. All of these methods have one basic principle in common: the optical spectrum of a tissue contains information about the biochemical composition and/or the structure of the tissue, and that information conveys diagnostic information. The biochemical information can be obtained by measuring absorption, fluorescence, or Raman scattering signals. Structural and morphological information may be obtained by techniques that assess the elastic-scattering properties of tissue. These basic approaches are useful for the detection of cancer as well as for other diagnostic applications such as hemoglobin saturation, intra-luminal detection of atherosclerosis, and simply the identification of different tissue types during procedures. Optical spectroscopic measurements can also be employed in the management of disease treatment. The site-specific pharmacokinetics of chemotherapy and photodynamic therapy agents can be used to customize dosage to the patient, and diagnostic spectroscopy can be used to monitor response to treatment. In recent years clinical studies have provided indications of potential efficacy, and some of these modalities are now entering a translational research stage, with an eye to approval and commercialization. A benefit of these methods is their inherent low cost and ease of implementation, generally mediated with small portable instruments, not requiring any specialized facilities, and eventually not requiring expert interpretation. This paper reviews briefly the most common methods of diagnostic optical spectroscopy, and reviews in greater depth recent clinical translational research invoking scattering spectroscopy as the enabling technology, which has been the experience of the authors.

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Section: Elastic Scattering Spectroscopymentioning

confidence: 99%

Spectrroscopic Sensing of Cancer and Cancer Therapy: Current Status of Translational Research

Bigio

Bown²

2004

Cancer Biology & Therapy

143

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“…

R_{i}^{d} [μ_{s}^{'} (λ)] = \frac{1}{π^{2} r_{s}^{2} r_{i}^{2}} \int_{A_{s}} {d A}_{s} \int_{A_{i}} {d A}_{i} R^{d} [μ_{s}^{'} (λ) | {boldr}_{s} - {boldr}_{i} |]

where R d is the well-known diffuse reflectance density 26,50 . The integrals here are numerically calculated over the area of the source fiber A s with radius r s and collection fibers A i with radii r i ( i =1, 2).…”

Section: Methodsmentioning

confidence: 99%

Light scattering spectroscopy identifies the malignant potential of pancreatic cysts during endoscopy

et al. 2017

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Pancreatic cancers are usually detected at an advanced stage and have poor prognosis. About one fifth of these arise from pancreatic cystic lesions. Yet not all lesions are precancerous, and imaging tools lack adequate accuracy for distinguishing precancerous from benign cysts. Therefore, decisions on surgical resection usually rely on endoscopic ultrasound-guided fine needle aspiration (EUS-FNA). Unfortunately, cyst fluid often contains few cells, and fluid chemical analysis lacks accuracy, resulting in dire consequences, including unnecessary pancreatic surgery for benign cysts and the development of cancer. Here, we report an optical spectroscopic technique, based on a spatial gating fibre-optic probe, that predicts the malignant potential of pancreatic cystic lesions during routine diagnostic EUS-FNA procedures. In a double-blind prospective study in 25 patients, with 14 cysts measured in vivo and 13 postoperatively, the technique achieved an overall accuracy of 95%, with a 95%confidence interval of 78–99%, in cysts with definitive diagnosis.

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“…[19] In vivo measurements of the reflectance spectral data and statistical analysis have been performed in an attempt to detect breast cancers, lesions in ovarian tissues, skin lesions including dysplastic nevi and basal cell carcinomas, and adenomatous colon polyps. [21][22][23][24] Recently, Johnson et al reported the study of spectral reflectance data, between 340 and 900 nm, acquired from 139 cancerous and normal sentinel nodes removed from 68 patients with breast cancers. [25] Statistical analysis of the spectral data yielded scores for discriminating different types of nodes with sensitivity and specificity comparable to those of frozen section histology.…”

Section: Spectroscopy Measurementsmentioning

confidence: 99%