Diffuse Reactive Angioendotheliomatosis Secondary to the Administration of Trabectedin and Pegfilgrastim

Abstract

Diffuse dermal angiomatosis is a rare benign condition considered a variant of reactive angioendotheliomatosis, usually related to vascular disease such as arteriovenous fistula or severe peripheral vascular disease. The most frequent clinical manifestations range from a solitary erythematous patch to an indurated plaque that may ulcerate. A clinical case of a 60-year-old woman who developed generalized livedoid lesions 2 days after the administration of intravenous trabectedin and subcutaneous pegfilgrastim for a recidivant myxoid liposarcoma has been reported. A biopsy of the skin lesions showed a pronounced proliferation of vessels in the upper dermis that was diagnosed as diffuse dermal angiomatosis.

Multifocal Diffuse Dermal Angiomatosis: A Reflection of High Cardiovascular Risk

“…After excluding cases with explicit unifocal involvement, involvement of both breasts, or un-reported location, 13 cases were found in the literature of DDA with multifocal involvement (1,(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14), as in our case (Table SI 1 ). Among them, 84.6% involved women, with mean age 58 years; 46.2% involved current smokers; and 46.2% featured atherosclerosis, as expected according to the review of Touloei et al (3) The thigh was the most common location, observed in 61.5% of cases.…”

Reticular Patches in a Patient With Multiple Myeloma: Answer

“…8 Several cases of RAE have been connected with antiphospholipid antibody syndrome and adverse drug reaction. 4,[9][10][11][12] Furthermore, RAE has been observed in adenopathy and extensive skin patch overlying a plasmacytoma syndrome, an early manifestation of polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes syndrome, which rapidly progresses without treatment and can become life-threatening. 13,14 Angiomatosis with cryoproteins, also known as angiopericytomatosis, is an infrequently recognized variant of RAE with few published cases in the literature.…”

Diffuse Dermal Angiomatosis of the Breast: A Distinct Entity in the Spectrum of Cutaneous Reactive Angiomatoses – Clinicopathologic Study of Two Cases and Comprehensive Review of the Literature

“…A wide spectrum of predisposing comorbid conditions have been associated with DDA in other body parts than the breast, such as advanced atherosclerotic vascular disease [ 6 , 7 , 8 , 9 , 10 ], iatrogenic arteriovenous fistula in the setting of chronic hemodialysis [ 11 , 12 ], monoclonal gammopathy [ 13 , 14 ], and the administration of trabectedin and pegfilgrastim in the context of liposarcoma in 1 case [ 15 ]. Cardiovascular risk factors, atherosclerotic vascular disease, and monoclonal gammopathy have also been described in association with DDAB.…”