Diffuse pulmonary ossification: an uncommon incidental autopsy finding

Tseung, Jason; Duflou, Johan

doi:10.1080/00313020500464912

Cited by 44 publications

(62 citation statements)

References 9 publications

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“…DPO has been reported in various contexts, including in patients with normal lungs (idiopathic DPO) (4,5); in those with preexisting cardiac diseases, particularly pulmonary congestion secondary to mitral stenosis (6,7); after severe lung injury (8,9); and in association with fibrosing interstitial lung disease (ILD) (10)(11)(12)(13)(14)(15). Previous studies of DPO have been limited by small patient numbers (11,14) or have been based on autopsy studies (1,16) and thus do not provide a clear idea of the frequency of ossification in fibrosing ILDs or its associations. The aims of our study were to determine the prevalence of DPO in patients with different types of fibrosing ILD and to determine whether there are differences among them.…”

Section: Advances In Knowledgementioning

confidence: 99%

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Diffuse Pulmonary Ossification in Fibrosing Interstitial Lung Diseases: Prevalence and Associations

et al. 2017

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Purpose:To investigate the prevalence of diffuse pulmonary ossification (DPO) in patients with fibrosing interstitial lung disease (ILD) and determine whether there are differences among the types of ILDs. Materials and Methods:Institutional review board approval was given and patient consent was not required for this study. Results:In the whole population, the prevalence of DPO was 166 (18.6%) and 106 (11.9%) of 892 patients according to definitions 1 and 2, respectively. The prevalence of DPO (definition 1) was significantly higher in patients with IPF (28.5%) than in those without IPF (8.3%, P , .001). Nine of 192 (4.7%) had chronic hypersensitivity pneumonitis (P , .001), and 27 of 244 (11.1%) had nonspecific interstitial pneumonia (P , .001). At multivariate analysis, DPO according to definition 1 was an independent predictor of IPF diagnosis (P , .001) and male sex (P = .003).Coarseness of fibrosing ILD (P = .011) and IPF diagnosis (P = .016) were independently associated with pulmonary ossification profusion. Conclusion:DPO is common in patients with fibrosing ILD and is significantly more prevalent in patients with IPF than in those with other fibrosing ILDs, and thus, computed tomographic signs of DPO may be helpful for diagnosis of IPF.q RSNA, 2017

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Section: Advances In Knowledgementioning

confidence: 99%

“…iffuse pulmonary ossification (DPO) in patients without background lung disease is a rare condition (1.63 of 1000 cases at autopsy) (1). The cause of the deposition of numerous small ossified nodules throughout the lung parenchyma is unknown (2,3).…”

Section: Advances In Knowledgementioning

confidence: 99%

Diffuse Pulmonary Ossification in Fibrosing Interstitial Lung Diseases: Prevalence and Associations

et al. 2017

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“…DPO is usually associated with cardiovascular or respiratory disease. Therefore, the number of idiopathic cases is very small (1)(2)(3)(4). We herein present an idiopathic case of DPO detected during a routine health examination.…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of Asymptomatic Diffuse Pulmonary Ossification Detected during a Routine Health Examination

et al. 2012

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A 26-year-old man presented at our hospital in 2008 to undergo detailed investigations as part of a routine health examination. Chest computed tomography (CT) showed linear and reticular opacities with, in part, diffuse calcification in the lung fields bilaterally. A surgical lung biopsy was performed and the histological findings were compatible with a diagnosis of diffuse pulmonary ossification (DPO) of the dendriform type. DPO usually occurs as a secondary disease. As the histological changes in interstitial fibrosis were minimal rather than diffuse and not significant enough to be regarded as interstitial pneumonia, we considered this to be an idiopathic case. However, the findings appear to suggest that inflammation and fibrosis were associated with ossification.

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“…Pulmonary ossification is a rare disorder in which mature bone is formed in the lung parenchyma in response to injury 1. Two histological types have been described: dendriform type ossification, and nodular pulmonary ossification.…”

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confidence: 99%

“…The dendriform type may be idiopathic or may be a consequence of chronic inflammation, and ossification occurs in and replaces the alveolar septae. However, nodular ossification may also be present in patients with no clinical or histological evidence of chronic pulmonary congestion, which indicates a degree of overlap between the two forms 1. Pulmonary ossification can occur quickly with relatively acute conditions 1.…”

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confidence: 99%

Pulmonary ossification: an unusual incidental finding of a transthoracic CT guided needle biopsy of a lung lesion

Fernández–Fernández

Durana-Tonder²,

Bello-Peón³

et al. 2010

Postgraduate Medical Journal

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Diffuse pulmonary ossification: an uncommon incidental autopsy finding

Cited by 44 publications

References 9 publications

Diffuse Pulmonary Ossification in Fibrosing Interstitial Lung Diseases: Prevalence and Associations

Diffuse Pulmonary Ossification in Fibrosing Interstitial Lung Diseases: Prevalence and Associations

A Rare Case of Asymptomatic Diffuse Pulmonary Ossification Detected during a Routine Health Examination

Pulmonary ossification: an unusual incidental finding of a transthoracic CT guided needle biopsy of a lung lesion

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