Diffuse optical detection of global cerebral ischemia in an adult porcine model

Abstract

Rapid screening for ischemic strokes in prehospital settings may improve patient outcomes by allowing early deployment of vascular recanalization therapies. However, there are no low‐cost and convenient methods that can assess ischemic strokes in such a setting. Diffuse correlation spectroscopy (DCS) is a promising method for continuous, noninvasive transcranial monitoring of cerebral blood flow. In this study, we used a DCS system to detect cerebral hemodynamics before and after acute ischemic stroke in pigs. Seven adult porcines were chosen to establish ischemic stroke models via bilateral common carotid artery ligation (n = 5) or air emboli (n = 2). The results showed a significant difference in blood flow index (BFI) between the normal and ischemic groups. Relative blood flow index (rBFI) exhibited excellent results. Therefore, the diffuse optical method can assess the hemodynamic changes in acute cerebral ischemic stroke onset in pigs, and rBFI may be a promising biomarker for identifying cerebral ischemic stroke.

Correlation of diabetic renal hypoperfusion with microvascular responses of the skeletal muscle: a rat model study using diffuse correlation spectroscopy

“…Even under the death condition, in which there was no blood supply owing to the removal of the heart, the renal BFI did not reach zero. The BFI values remaining during the occlusion and death conditions may indicate the biological zero state resulting from the Brownian motion of macromolecules within the interstitium [ 44 ], which is also supported by the previous flow phantom study [ 22 ] and the in vivo porcine DCS study [ 45 ].…”