Diffuse neonatal hemangiomatosis with partial response to propranolol

Ferrándiz, Lara; Toledo-Pastrana, T.; Moreno‐Ramírez, D.; Bardallo-Cruzado, Leonor; Pérez-Bertólez, S; Luna-Lagares, Salud; Ríos‐Martín, J.J.

doi:10.1111/ijd.12155

Cited by 6 publications

(5 citation statements)

References 14 publications

(18 reference statements)

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“…The rapid proliferation of the hemangiomas ceased and then regressed in all patients. The response to propranolol is more rapid than that to corticosteroids, usually 14 days; how ever, some studies have reported a response up to 8 months after treatment 18) . Propranolol downregulates angiogenetic growth factors such as vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) by blocking beta adrenoceptors 19,20) .…”

Section: Case Reportmentioning

confidence: 99%

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Diffuse Neonatal Hemangiomatosis with Unilateral Cranial Nerve Palsy Improved by Propranolol

et al. 2016

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Diffuse neonatal hemangiomatosis (DNH) is characterized by multiple capillary or cavernous hemangiomas on the skin and internal organs occurring during the neo natal period. It is a lifethreatening condition due to highoutput heart failure with a mortality rate of 6085% without proper treatment. The areas that are most commonly involved include the skin (100%), liver (64100%), and central nervous system (52%). Corticosteroids are the drugs of choice as an initial treatment and have a response rate of 3060%. We present here a case of a newborn baby with multiple hemangiomas on her skin (scalp, lips, neck, back, shoulder, arm, buttock, and leg), brain (right cere bellum, pons, and medulla oblongata), lungs, liver, kidney, and bones. She suffered from 6 th , 7 th , 9 th , 10 th , and 12 th cranial nerve palsy resulting from hemorrhage of the hemangiomas in the brain. The firstline treatment of prednisolone (4 mg/kg/day) was not effective and propranolol (2 mg/kg/day) was administered as a secondline treatment. After 2 weeks of treatment, the hemangio mas had decreased in size with no associated acute hemorrhage. The infant is now 10 months old and both the multiple hemangiomas and cranial nerve palsy have improved. Propranolol was effective without significant adverse effects in treating DNH resistant to corticoste roids.

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Section: Case Reportmentioning

confidence: 99%

“…(C) The hemangioma on the left kidney was decreased in size on abdominal CT. in some intensive care units, it is used as a firstline treatment. In one prospective study, 31 newborn patients with infantile hemangioma were treated with 3 mg/kg/day of propranolol as an initial treatment and this was shown to be effective without significant adverse effects18)…”

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Diffuse Neonatal Hemangiomatosis with Unilateral Cranial Nerve Palsy Improved by Propranolol

et al. 2016

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“…[2][3][4] However, there was a case in which cutaneous lesions enlarged despite the use of propranolol. In the past cases, propranolol was started at the rate of 0.5-1.5 mg/kg per day and the maximum was 2.0-4.0 mg/kg per day.…”

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confidence: 99%

“…The regression of IHH was recognized from 1 to 4 months, and CIH from 1 to 14 months. [2][3][4] However, there was a case in which cutaneous lesions enlarged despite the use of propranolol. 3 Our case showed remarkable responses within 1 month of the treatment, and CIH markedly regressed and IHH completely resolved after 1 year.…”

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confidence: 99%

“…[2][3][4] However, there was a case in which cutaneous lesions enlarged despite the use of propranolol. 3 Our case showed remarkable responses within 1 month of the treatment, and CIH markedly regressed and IHH completely resolved after 1 year. As the MIB-1 index of the tumor cells was high, we assume that propranolol administration was especially effective when the tumor is in the proliferating phase.…”

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