Diffuse Necrotic Ulcerations Revealing Lepromatous Leprosy with Lucio's Phenomenon

Abstract

We report a 62-year-old farmer who consulted with multiple chronic wounds over his limbs and chest. Physical examination revealed multiple ulceration, madarosis and infiltration of ear lobes. Slit skin smear showed numerous acid-fast bacilli consistent with a diagnosis of lepromatous leprosy associated with Lucio's phenomenon. Administration of thalidomide together with MDT resulted in a huge improvement.

Antiphospholipid antibodies in a patient of Lucio phenomenon presenting with the gangrene of digits

“…Lucio phenomenon can be the initial presentation of the disease, presenting as widespread necrotic ulcerations. 3 Necrotic lesions of Lucio phenomenon can mimic cutaneous small or mixed vessel vasculitis clinically, which was true for our patient too. Livedo racemosa-like lesions and gangrene involving multiple digits, in this case, can be attributed to the thrombotic vasculopathy of antiphospholipid syndrome.…”

Sebuah Kasus Lucio Phenomenon yang Fatal pada Pasien Lucio’s Leprosy

“…Perubahan-perubahan ini merupakan ciri khas Lucio's Leprosy. 10 Sedangkan gambaran histopatologi Lucio Phenomenon ditunjukkan dengan adanya lesi nekrotik yang pertama disebabkan karena terjadinya vaskulopati oklusif, tanpa disertai gejala sistemik, dan yang kedua disebabkan karena adanya reaksi kusta yang memperburuk kerusakan pembuluh darah dan menyebabkan munculnya tanda dan gejala sistemik, 10 hal ini juga tampak pada hasil biopsi pasien.…”