Diffuse Micronodular Lung Disease: HRCT and Pathologic Findings

Lee, Kyung Soo; Kim, Tae Sung; Han, Joungho; Hwang, Jung Hwa; Yoon, Jung Hwan; Kim, Yookyung; Yoo, Seon Young

doi:10.1097/00004728-199901000-00022

Cited by 83 publications

(45 citation statements)

References 15 publications

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“…Parenchymatous changes revealed in HRCT are often invisible, poorly visible, or doubtful in conventional radiography 14) . HRCT can reveal small opacities earlier than conventional radiograms and assessment of their concentration is more precise 15) . HRCT sections detected small and multivocal opacities than more accurately and earlier radiograms 16) .…”

Section: Discussionmentioning

confidence: 99%

The Value of High Resolution Computed Tomography in the Diagnostics of Small Opacities and Complications of Silicosis in Mine Machinery Manufacturing Workers, Compared to Radiography

Sun

Jin

et al. 2008

Journal of Occupational Health

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The Value of High Resolution Computed Tomography in the Diagnostics of Small Opacities and Complications of Silicosis in Mine Machinery M a n u f a c t u r i n g W o r k e r s , C o m p a r e d t o Radiography: Jinkai SUN, et al. Division of Pneumoconiosis, School of Public Health, ChinaMedical University, China-The purpose of this study was to assess the value and usefulness of high resolution computed tomography (HRCT) in the diagnostics of small opacities and complications of silicosis in mine machinery manufacturing workers, compared to conventional radiograms. The diagnosis of silicosis is mainly based on the radiological findings of workers exposed to the dust causing lung fibrosis. However, on radiograms many parenchymal structures overlap, which limits the sensitivity and specificity of the method. Difficulties in accurate interpretation of conventional radiograms in silicosis also result from their relatively low resolution. We randomly selected 30 I period silicosis patients from 77 I period silicosis patients working at a mine machinery manufacturing company. Out of 1078 non-silicosis and 162 0 + period silicosis subjects, 30 non-silicosis and 30 0 + period silicosis subjects were randomly selected and matched with the 30 I period silicosis subjects by age (± 3.0 yr) and occupational exposure time (± 2.0 yr). Chest Xrays were taken at maximal inspiration. For the HRCT examination, the GE Somatom plus apparatus was used. Eight, five and six subjects were respectively diagnosed as 0 + , I or I + period silicosis based on HRCT among 90 subjects whose original diagnoses were nonsilicosis, 0 + or I period silicosis based on radiography. The numbers of small opacities in HRCT scans were significantly higher than those seen in radiography in all lung zones (p<0.01). HRCT was more sensitive than radiography in detecting small opacities of midout zones of the lung, but no statistical significance was found between the two methods in the detection of small opacities of lower zones of the lung. A statistically significant increase in the detectability of bulla, emphysema, pleural, mediastinal and hilar changes was observed (p<0.05). HRCT might be more sensitive than radiography in detecting lung parenchymal changes suggestive of silicosis. (J Occup Health 2008; 50: 400-405)

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Section: Discussionmentioning

confidence: 99%

The Value of High Resolution Computed Tomography in the Diagnostics of Small Opacities and Complications of Silicosis in Mine Machinery Manufacturing Workers, Compared to Radiography

Sun

Jin

et al. 2008

Journal of Occupational Health

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“…(47) Miliary metastasis are frequently due to thyroid cancer, renal cancer, melanoma, or other malignancies, whereas larger and less profuse metastases tend to be adenocarcinomas in adults, typically originating from the lung, breast, or gastrointestinal tract.…”

Section: Clinical and Histopathological Correlationsmentioning

confidence: 99%

Padrões tomográficos das doenças intersticiais pulmonares difusas com correlação clínica e patológica

et al. 2008

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High-resolution computed tomography (HRCT) is the radiological imaging technique best suited to revealing changes in lung structure. Various HRCT findings, taken together, can represent typical patterns. These patterns, in conjunction with the anatomical distribution of findings and with clinical data, can narrow the differential diagnosis of diffuse interstitial lung disease and, in many cases, indicate the correct diagnosis with a high degree of accuracy. The most common HRCT patterns seen in cases of diffuse interstitial lung diseases are the nodular pattern, linear/reticular opacities, cystic lesions, ground-glass opacities and consolidations. This article reviews the correlations between HRCT patterns and pathologic findings, summarizing the most common causes, as well as detailing the methods of investigation employed in order to diagnose the most common types of chronic diffuse lung disease.Keywords: Lung diseases, interstitial/pathology; Tomography, X-Ray computed; Diagnostic techniques, respiratory system. ResumoA tomografia de alta resolução (TCAR) é a técnica de imagem radiológica que reflete mais de perto as alterações da estrutura pulmonar. Os vários achados tomográficos podem ser combinados para formar padrões típicos. Estes, conjuntamente com a distribuição anatômica dos achados, e com os dados clínicos, podem estreitar o diagnóstico das doenças intersticiais pulmonares difusas, e em vários casos sugerir o diagnóstico correto com alto grau de acurácia. Os padrões mais comuns das doenças intersticiais pulmonares difusas na TCAR são o nodular, linear e reticular, lesões císticas, opacidades em vidro fosco e consolidações. Este artigo revisa as correlações entre os padrões tomográficos na TCAR e os achados patológicos e resume as causas mais comuns e os métodos de investigação para se atingir um diagnóstico nas doenças pulmonares crônicas difusas mais comuns.Descritores: Doenças pulmonares intersticiais/patologia; Tomografia computadorizada por raios X; Técnicas de diagnóstico do sistema respiratório.* Study carried out in the

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“…A tomografia computadorizada de alta resolução (TCAR) mostrou-se superior à radiografia simples e à tomografia convencional de tórax na avaliação da presença e extensão das alterações parenquimatosas, já que permite a localização da doença ao nível do lóbulo pulmonar secundário (8)(9)(10) . Por isso, esse método pode, em determinadas circunstâncias, ser capaz de distinguir lesões residuais de lesões recentes, mostrar precocemente nódulos miliares e lesões centrolobulares, estas últimas caracterizando a disseminação broncogênica, avaliar a presença de pequenas cavitações, de opacidades em vidro fosco e de espessamento dos septos interlobulares, sendo especialmente útil nos pacientes com baciloscopia negativa, já que pode determinar a instituição de antibioticoterapia antes dos resultados da cultura (5,8,11) .…”

Section: Introductionunclassified

Tuberculose pulmonar: achados na tomografia computadorizada de alta resolução do tórax em pacientes com doença em atividade comprovada bacteriologicamente

Campos¹,

Marchiori²,

Rodrigues³

2002

J. Pneumologia

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Objetivo: Descrever os achados em pacientes com tuberculose pulmonar em atividade na tomografia computadorizada de alta resolução e o padrão de distribuição das lesões pelo parênquima pulmonar.Casuística e método: Foram analisadas retrospectivamente as tomografias de alta resolução de 42 pacientes com diagnóstico bacteriológico de tuberculose pulmonar ou forte suspeita clínica, com posterior confirmação bacteriológica. Resultados: Os principais sinais sugestivos de atividade encontrados foram nódulos do espaço aéreo (83%), nódulos centrolobulares (74%), aspecto de árvore em brotamento (67%), cavitações (67%), espessamento das paredes brônquicas (55%), consolidações (48%), opacidade em vidro fosco (21%), e espessamento do interstício pulmonar (9%). Conclusão: A tomografia computadorizada de alta resolução do tórax pode sugerir fortemente atividade da doença, sendo particularmente útil nos pacientes com baciloscopias negativas e/ou radiografias indeterminadas, permitindo a instituição de tratamento adequado, antes mesmo do crescimento da micobactéria em meio de cultura. (J Pneumol 2002;28(1):23-9) Pulmonary tuberculosis: findings on high resolution computerized tomography of active disease on patients with bacteriological confirmation Background: The aim of this study was to describe the signs of active tuberculosis in patients submitted to high resolution computerized tomography and the distribution of lesions along the pulmonary parenchyma. Material and methods: The high resolution CTs performed on 42 patients with tuberculosis either bacteriologically diagnosed or clinical suspected and later confirmed by bacteriological tests were studied. Results: The signs of disease activity observed were airspace nodule (83%), centrilobular nodule (74%), tree-in-bud pattern (67%), cavitations (67%), bronchial thickening (55%), parenchymal consolidations (48%), ground glass opacity (21%) and thickening of the inter and intralobular septa (9%). Conclusion: High resolution computed tomography can be strongly suggestive of disease activity, is particularly helpful in patients with negative smear and/or undetermined radiographs, and allows the establishment of proper treatment, even before mycobacteria are identified in means of culture.

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Diffuse Micronodular Lung Disease: HRCT and Pathologic Findings

Abstract: By showing the distribution of micronodules in and around the secondary pulmonary lobule, HRCT enables the narrowing of the differential diagnosis of DMLD. CT findings reflect gross morphologic features of pathologic examination.

Cited by 83 publications

References 15 publications

The Value of High Resolution Computed Tomography in the Diagnostics of Small Opacities and Complications of Silicosis in Mine Machinery Manufacturing Workers, Compared to Radiography

The Value of High Resolution Computed Tomography in the Diagnostics of Small Opacities and Complications of Silicosis in Mine Machinery Manufacturing Workers, Compared to Radiography

Padrões tomográficos das doenças intersticiais pulmonares difusas com correlação clínica e patológica

Tuberculose pulmonar: achados na tomografia computadorizada de alta resolução do tórax em pacientes com doença em atividade comprovada bacteriologicamente

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