Diffuse malignant peritoneal mesothelioma: Systematic review of clinical management and biological research

Baratti, Dario; Kusamura, Shigeki; Deraco, Marcello

doi:10.1002/jso.21787

Cited by 65 publications

(42 citation statements)

References 80 publications

(184 reference statements)

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“…All patients received crystalloids, colloids, and fresh frozen plasma (mean, 4.8; range, 2-12) during the operation, whereas 27 patients were transfused with red blood cells (mean, 2.8; range, [1][2][3][4][5][6]. No serious intraoperative complications during HIPEC were recorded.…”

Section: Resultsmentioning

confidence: 99%

“…[1][2][3] It is a complex procedure that includes abdominal and pelvic peritonectomies with combined organ resections in order to eradicate all macroscopic disease, and then perfusion of the abdominal cavity with heated chemotherapeutic agents, in an effort to eradicate all microscopic residual disease. 4 The indications of the method continue to expand because favorable 5-year survival rates were observed in low-grade malignancies, such as peritoneal adenomucinosis.…”

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confidence: 99%

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Hemodynamic Monitoring During Heated Intraoperative Intraperitoneal Chemotherapy Using the FloTrac/Vigileo System

Mavroudis¹,

Alevizos²,

Stamou³

et al. 2015

International Surgery

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Cytoreductive surgery with HIPEC has provided a chance for long-term survival in selected patients. However, perioperative management remains a challenge for the anesthesiology team. The aim of this study was to evaluate the changes in hemodynamic parameters during hyperthermic intraperitoneal chemotherapy (HIPEC) using the FloTrac/ Vigileo system. Forty-one consecutive patients undergoing cytoreductive surgery and HIPEC were enrolled. Heart rate (HR), esophageal temperature, and cardiac output (CO) steadily increased until the end of HIPEC. In the first half of HIPEC, systolic blood pressure (SBP) and central venous pressure (CVP) increased whereas systemic vascular resistance (SVR) decreased; SVR stabilized in the second half. Diastolic blood pressure (DBP), mean arterial pressure (MAP), and stroke volume (SV) showed no significant variation. Male gender was related to increased CVP, CO, and SV, and decreased SVR; age .55 years was related to increased SBP, and peritoneal cancer index (PCI) was correlated with HR, DBP, and SV. PCI .14 was associated with increased HR and decreased DBP and MAP. American Society of Anesthesiologists score .1 was related to decreased CO and SV. Patients undergoing HIPEC develop a hyperdynamic circulatory state because of the increased temperature, characterized by a steady decrease in SVR and continuous increase in HR and CO. FloTrac/Vigileo system may provide an easy-to-handle, noninvasive monitoring tool.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Hemodynamic Monitoring During Heated Intraoperative Intraperitoneal Chemotherapy Using the FloTrac/Vigileo System

Mavroudis¹,

Alevizos²,

Stamou³

et al. 2015

International Surgery

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“…Historically, patients treated with palliative surgery with or without chemotherapy experienced a median os of approximately 1 year 35,36 . With novel systemic chemotherapy regimens consisting of a combination of pemetrexed and platinum compounds or gemcitabine, the median os has reached 8.7-26.7months 37,38 .…”

Section: Malignant Peritoneal Mesotheliomamentioning

confidence: 99%

Treatment of Peritoneal Surface Malignancies with Hyperthermic Intraperitoneal Chemotherapy—Current Perspectives

2016

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Peritoneal carcinomatosis (ptc) represents advanced malignant disease and has generally been associated with a grim prognosis. Peritoneal surface malignancy is often the major source of morbidity and mortality; it is of major concern in cancer management. Although ptc is categorized as metastatic disease, it represents a special disease pattern considered to be a locoregional disease limited to the abdominal cavity. The combination of cytoreductive surgery (crs) and intraoperative hyperthermic intraperitoneal chemotherapy (hipec) has successfully been used as locoregional treatment for selected patients with ptc from gastric, colorectal, and ovarian cancer; with mesothelioma; and with pseudomyxoma peritonei. In the prophylactic setting, hipec can also be used to prevent ptc in high-risk patients, and the first results of the "second-look" approach are promising. Patient selection-in which the risks of perioperative morbidity and mortality, which are analogous to those for any other major gastrointestinal surgery, are assessed-is of utmost importance. Those risks have to be weighed against the anticipated survival benefit, which depends mainly on tumour biology, extent of disease, and probability of achieving complete crs. The present review discusses the principles of crs and hipec, the most significant recent clinical data, and current perspectives concerning the application of this treatment modality in various malignancies. Ongoing trials and future directions are noted. It appears that the combination of crs and hipec is an indispensable tool in the oncologist's armamentarium.

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“…DMPM is ultimately fatal although advances have been made in therapeutic strategies for surgically resectable disease. The combination of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy with cisplatin plus doxorubicin or mitomycin-C has been shown to improve overall survival (Baratti et al, 2011;Turner et al, 2012). Patients with inoperable DMPM may undergo systemic chemotherapy with cisplatin and pemetrexed and/or palliation surgery.…”

Section: Conventional Therapy Of Malignant Mesotheliomamentioning

confidence: 99%

The Role of Inflammation in Development and Therapy of Malignant Mesothelioma

B.¹

2012

American Medical Journal

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Malignant Mesothelioma (MM) is an asbestos related malignancy with a poor prognosis and limited therapeutic approaches. The pathogenesis of MM has been linked to asbestos induced inflammation. Asbestos exposure results in reactive oxygen species generation, infiltration of inflammatory cells and prolonged release of multiple cytokines, oxidants and growth factors. The role of inflammation in MM has led to the evaluation of inflammatory profiles as prognostic and therapeutic markers. Additionally, inflammatory pathways are under investigation for potential therapeutic interventions. In this review, we discuss the role of inflammation in MM pathogenesis, inflammatory markers with potential clinical impact for MM and clinical trials that target inflammatory pathways and responses for treatment of MM. Ultimately, MM remains a difficult to treat cancer that requires multimodality therapy.

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Diffuse malignant peritoneal mesothelioma: Systematic review of clinical management and biological research

Cited by 65 publications

References 80 publications

Hemodynamic Monitoring During Heated Intraoperative Intraperitoneal Chemotherapy Using the FloTrac/Vigileo System

Hemodynamic Monitoring During Heated Intraoperative Intraperitoneal Chemotherapy Using the FloTrac/Vigileo System

Treatment of Peritoneal Surface Malignancies with Hyperthermic Intraperitoneal Chemotherapy—Current Perspectives

The Role of Inflammation in Development and Therapy of Malignant Mesothelioma

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