Diffuse Lymphadenopathy as the Presenting Manifestation of Systemic Lupus Erythematosus

Smith, Lanaya Williams; Petri, Michelle

doi:10.1097/rhu.0b013e3182a6a924

Cited by 26 publications

(20 citation statements)

References 15 publications

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“…According to Systemic Lupus International Collaborating Clinics (SLICC) classification criteria, generalized lymphadenopathy is not considered a criterion for diagnosis [ 6 ]. The prevalence of generalized lymphadenopathy is by far less as seen in SLE patients previously [ 1 ]. The precise prevalence of lymphadenopathy in SLE patient is unknown.…”

Section: Discussionmentioning

confidence: 99%

“…The precise prevalence of lymphadenopathy in SLE is unknown. There are several case reports suggesting that generalized lymphadenopathy could be the first manifestation of SLE [ 1-4 ]. Here we present a 23-year-old female who came to our hospital with diffuse generalized lymphadenopathy, fatigue, malaise, weight loss, nausea, and bilateral lower extremity edema.…”

Section: Introductionmentioning

confidence: 99%

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Generalized Lymphadenopathy as Presenting Feature of Systemic Lupus Erythematosus: Case Report and Review of the Literature

et al. 2016

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Lymphadenopathy could represent a vast spectrum of etiologies including infectious and non-infectious diseases. Besides proper history taking, physical examination, and laboratory investigations, a tissue diagnosis is often necessary to unmask the cause of generalized lymphadenopathy. Here we present a 23-year-old woman who was admitted for diffuse generalized lymphadenopathy, fatigue, malaise, weight loss, nausea, and bilateral lower extremity edema. She reported a history of seizures as well as stroke 2 years prior with no other medical conditions present. Although malignant and infectious etiologies were initially the primary targets for workup, her history of seizures and stroke remained a dilemma. Extensive workup for malignant and infectious diseases was unrevealing; however, rheumatologic workup was eventually positive for systemic lupus erythematosus (SLE). This case illustrates that extensive generalized diffuse lymphadenopathy may be a presenting feature of SLE and should be considered in the differential diagnosis of patients presenting with diffuse lymphadenopathy and constitutional symptoms.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Generalized Lymphadenopathy as Presenting Feature of Systemic Lupus Erythematosus: Case Report and Review of the Literature

et al. 2016

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“…Responded to immunosuppression + rituximab. USA (Smith and Petri 2013 ) 27 year old Female SLE ANA, anti dsDNA, anticardiolipin IgG and IgM, anti-Smith, anti-Ro, anti-La. Developed lupus nephritis.…”

Section: Discussionmentioning

confidence: 99%

Fatal Kikuchi-like lymphadenitis associated with connective tissue disease: a report of two cases and review of the literature

Sharma

Rankin

2015

SpringerPlus

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IntroductionKikuchi-Fujimoto disease, is usually a benign self-limiting disease which typically affects young females under the age of 30 years and resolves without treatment within six months. However, when it occurs in the context of connective tissue disease, particularly systemic lupus erythematosus (SLE), it is usually associated with a flare-up of the patient’s symptoms, requiring treatment, and can lead to severe, potentially life-threatening sequelae.Case descriptionHere, we report and compare two cases of unclassifiable connective tissue disease who developed a Kikuchi-like lymphadenitis and sepsis-like clinical syndrome, including disseminated intravascular coagulation, which proved rapidly fatal.Discussion and evaluationIn our review of the literature, we found 55 cases of Kikuchi-Fujimoto disease occurring in the context of definite connective tissue disease, 50 of which were associated with SLE. Of the 55 cases, 22 (40%) had simultaneous onset with, 19 (35%) predated the onset of and 14 (25%) developed after the associated connective tissue disease. Life-threatening autoimmune sequelae were reported in 8 cases, 2 of which were fatal. The aetiology of the association remains unknown.ConclusionKikuchi-Fujimoto disease is a histopathological diagnosis, and although the classical form appears to represent a distinct entity, it is unclear whether it is always the same entity, regardless of the context in which it occurs, or whether it represents a histological pattern with a variety of possible causes. In any case, the possibility of auto-immune sequelae in patients with known autoimmune disease should always be considered if these patients present with a sepsis-like clinical syndrome and no infective source is identified.

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“…Lenfadenopati, SLE hastalarında %12-78 oranında değişen sıklıkta görülmekte olup, başlangıç semptomu olarak nadirdir [4,5] . Genellikle jeneralize LAP şeklindedir [6] . Bu yazıda başlangıç semptomu olarak servikal ve aksiller bölgeye sınırlı LAP ve ateş yüksekliği yakınması ile başvuran lenf bezi patolojik incelemesi lupus lenfadeniti olarak sonuçlanan bir olgu sunulmuştur.…”

Section: Sayın Editörunclassified

A Rare Case of Lupus Lymphadenopathy in the Differential Diagnosis of Lymphadenopathy

Pullukçu¹,

Akyol²,

Soyer³

et al. 2019

mjima

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Diffuse Lymphadenopathy as the Presenting Manifestation of Systemic Lupus Erythematosus

Cited by 26 publications

References 15 publications

Generalized Lymphadenopathy as Presenting Feature of Systemic Lupus Erythematosus: Case Report and Review of the Literature

Generalized Lymphadenopathy as Presenting Feature of Systemic Lupus Erythematosus: Case Report and Review of the Literature

Fatal Kikuchi-like lymphadenitis associated with connective tissue disease: a report of two cases and review of the literature

A Rare Case of Lupus Lymphadenopathy in the Differential Diagnosis of Lymphadenopathy

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