Diffuse lung uptake of Tc-99m-sulfur colloid

Stadalnik, Robert C.

doi:10.1016/s0001-2998(80)80032-8

Cited by 6 publications

(1 citation statement)

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“…The liver-spleen scan permits estimation of liver and spleen size and of isotope accumulation in the lung, expressed as the "liver-lung ratio. " Hunter syndrome patients have been shown to have an abnormally high lung uptake, thought to be due to uptake of the isotope by macrophages in lung tissue [Klingensmith et al, 1975;Stadalnik, 1980;Witner, Perl, and Johnson, 19761. Table I1 shows that no significant changes were found for patients SR and MS.…”

Section: Clinical Evaluationsmentioning

confidence: 99%

Administration of iduronate sulfatase by plasma exchange to patients with the hunter syndrome: A clinical study

et al. 1982

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The Hunter syndrome (MPS II) is the only mucopolysaccharidosis in which there is appreciable activity of the deficient enzyme in normal plasma. We performed enzyme-replacement treatment by plasma exchange in five Hunter syndrome children. Carefully monitoring the cardiovascular status, we administered monthly single plasma volume exchanges for a 3 to 8 mo period. The results indicate a substantial gain of enzyme activity, persisting with a t50% = 19 +/- 5 hr. The maximal level and persistence of increased enzyme activity did not change after repeated exchanges, suggesting that immune responses were not elicited. Despite this, no demonstrable clinical benefit was apparent when the study group was compared with an age-matched control group of Hunter syndrome patients.

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Section: Clinical Evaluationsmentioning

confidence: 99%