Diffuse Lepromatous Leprosy of Mexico (Spotted Leprosy of Lucio)

Arnold, Harry L.

doi:10.1001/archderm.1950.01530110129010

Cited by 5 publications

(3 citation statements)

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“…Lucio and Alvarado first described Lucio phenomenon in 1852 as a necrotizing lepra reaction occurring as a complication of the non-nodular form of leprosy in Mexico. 5 In 1948, Latapi and Zamora recognized this reaction histopathologically as a form of vasculitis and emphasized its exclusive occurrence in previously untreated diffuse nonnodular leprosy which they called Lucio's leprosy or pure and primitive diffuse lepromatosis. They termed the distinct lepra reaction as erythema necroticans or Lucio phenomenon.…”

Section: Discussionmentioning

confidence: 99%

Recurrent Ulcerations and Neuropathy in a Filipino Child with Previously Undiagnosed Leprosy: A Case of Lucio Phenomenon in the Philippines

Gervasio¹,

Pandapatan²,

Dofitas³

2019

Acta Med Philipp

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Lucio phenomenon is a distinct necrotizing lepra reaction arising from diffuse lepromatous leprosy that may easily be mistaken for other systemic conditions. We report a 17-year old female admitted for a 4-year history of recurrent, extensive ulcerations with crusting and purulent discharge, involving the arms, legs, face, and back. Clinical presentation, slit skin smear and skin biopsy confirmed the diagnosis of Lucio phenomenon and treatment with multidrug therapy resulted in resolution of the ulcerations.

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Section: Discussionmentioning

confidence: 99%

Recurrent Ulcerations and Neuropathy in a Filipino Child with Previously Undiagnosed Leprosy: A Case of Lucio Phenomenon in the Philippines

Gervasio¹,

Pandapatan²,

Dofitas³

2019

Acta Med Philipp

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“…The condition is mainly seen in Costa Rica 9 and the Sinaloa and Jallisco provinces of Mexico 3,10 . The condition has also been reported from California, 4,11 Lousiana, 12 Hawaii, 13,14 Brazil, 15 Argentina, Cuba, 16 South Africa, 17 Paraguay, 18 Portugal, 19 France, 20,21 Japan, 18,22 Spain, and the Near East 23,24 . A few reports of the disease have also come from the Netherlands 25 and the South Pacific 26 .…”

Section: Global Epidemiologic Perceptionmentioning

confidence: 95%

Lucio's phenomenon/erythema necroticans

Sehgal¹

2005

Int J Dermatology

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Lucio's phenomenon/erythema necroticans is a peculiar reaction pattern that occurs in untreated pure primitive diffuse lepromatous leprosy (PPDL) and/or relapsing leprosy recognized as spotted leprosy of Lucio. The small number of reported cases in the world literature suggests that it is fairly uncommon. Its clinical features are fairly characteristic and consist of extensive, bizarre, painful ulcerations of the skin, with constitutional symptoms being conspicuous by their absence. The clinical diagnosis is confirmed by microscopic pathology marked by proliferation and mobilization of polyblasts and histiocytes, dilatation, endothelial proliferation, luminal occlusion, and thrombosis of the superficial and mid-dermal blood vessels and demonstration of acid-fast bacilli in the blood vessel walls. Its precise pathogenesis is still unclear, but is believed to occur either through the usual or the alternate pathway of complement activation in the natural history of erythema nodosum leprosum. The clinical and immunological features of reactions in leprosy, including erythema nodosum leprosum, are well known and have been critically evaluated elsewhere.

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“…This is primarily seen in Costa Rica (3) and the Sinaloa and 1allisco provinces of Mexico (4,5). However, it has also been reported from California (6,7), Lousiana (8), Hawaii (9,10), Brazil (11), Argentina, Cuba (12), South Africa (13), Spain, and the Near East (14,15). The onset of the Lucio phenomenon is a gradually spreading purplish erythema, which then forms a hemorrhagic infract or plaque followed by a blister.…”

Section: Introductionmentioning

confidence: 95%

Contemplative Immune Mechanism of Lucio Phenomenon and Its Global Status

Sehgal

Srivastava

Sharma

1987

The Journal of Dermatology

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Lucio's phenomenon is infrequent in our experience. Only 2 young men on multi-drug therapy were seen among 36 erythema nodosum leprosum reaction cases in the last four years. It first appeared as extensive crops of puerpuric macules which transformed into dome-shaped polygonal pustules and multiangular, bizarre, punched out ulcers. Necrotic greyish-white debris was prominent the histological features were diagnostic. Multi-drug therapy seemed to have instigated the process. The classical as well as the alterative pathway of complement activation is incriminated in its probable immune mechanism.

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Diffuse Lepromatous Leprosy of Mexico (Spotted Leprosy of Lucio)

Cited by 5 publications

References 2 publications

Recurrent Ulcerations and Neuropathy in a Filipino Child with Previously Undiagnosed Leprosy: A Case of Lucio Phenomenon in the Philippines

Recurrent Ulcerations and Neuropathy in a Filipino Child with Previously Undiagnosed Leprosy: A Case of Lucio Phenomenon in the Philippines

Lucio's phenomenon/erythema necroticans

Contemplative Immune Mechanism of Lucio Phenomenon and Its Global Status

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