Diffuse large B cell lymphoma: cutaneous presentation

Ferrão, Joana Branco; Barreira, João Vasco; Marote, Sara; Parmanande, Anuraj

doi:10.1136/bcr-2018-226839

Cited by 4 publications

(3 citation statements)

References 3 publications

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“…Secondary cutaneous involvement of DLBCL is not uncommon, and clinical presentations can vary from nodules to infiltrated plaques 4 . Secondary lymphomas are similar to the primary lymphoma from a histological and immunohistochemical perspective; however, the nodular, well‐demarcated infiltrate of densely packed lymphoid cells in the dermis 5 eliminates this as a diagnosis in our case.…”

Section: Discussionmentioning

confidence: 71%

Fleshy friable nodule of the forehead

et al. 2021

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Section: Discussionmentioning

confidence: 71%

Fleshy friable nodule of the forehead

et al. 2021

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“…Depending on the site of involvement, there are 2 distinct subsets: primary cutaneous DLBCL which initially presents on the skin and DLBCL accompanied by secondary spread to the skin [6]. e presence of multiple skin lesions and time of evolution at presentation were associated with poorer prognosis in secondary cutaneous DLBCL [7]. In this patient, we assumed that her cutaneous manifestation was initial presentation of disseminated DLBCL.…”

Section: Discussionmentioning

confidence: 86%

Diffuse Large B Cell Lymphoma with Cutaneous and Gastrointestinal Involvement

Kyaw

Aye

Htun

2022

Case Reports in Gastrointestinal Medicine

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Diffuse large B cell lymphoma (DLBCL) is the histological subtype of non-Hodgkin’s lymphoma, representing approximately 30%. The most common primary extranodal sites of DLBCL are the gastrointestinal (GI) tract, the head and neck, and the skin/soft tissue. We report a case of DLBCL with cutaneous involvement presenting with skin nodules and GI manifestations such as obstructive jaundice and upper GI bleeding. Malignant cystic pancreatic tumor occupying the head and body with invasion to lower end of common bile duct and periampullary region causing biliary obstruction and mesenteric lymphadenopathy were found in abdominal computed tomography and endoscopic ultrasonography. There was also a large gastric ulcer (Forrest IIa) at the greater curvature of body of the stomach. Histopathological results of the skin and stomach were consistent with diffuse large B cell lymphoma; gastric biopsy being negative for leucocyte common antigen. The patient was considered to have disseminated DLBCL. The aim of the present case report was to present the clinical, radiological, and histological characteristics of the patient, which may aid physicians in diagnosing involvement of multiple extranodal sites in DLBCL.

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“…Primary cutaneous DLBCL on the leg tends to occur in older women 2. Secondary cutaneous involvement in DLBCL may occur with more extensive skin lesions and indicates poorer prognosis compared with primary cutaneous DLBCL 34…”

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confidence: 99%