Diffuse large B-cell lymphoma with uncommon cardiac invasion

Daralammouri, Yunis; Hamayel, Hamza; Ismail, Yahya; Majadla, Sajed; Odeh, Razan

doi:10.1177/2050313x211070942

Cited by 3 publications

(11 citation statements)

References 17 publications

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“…Multifocal lymphoma with cardiac involvement is associated with a high death risk. The prognosis of lymphoma with cardiac involvement has a 10% survival rate of 9–12 months if untreated 4 . Chemotherapy is a mainstay in treating B‐cell non‐Hodgkin's lymphoma with cardiac involvement to improve survival rate 1,2,4 .…”

Section: Figurementioning

confidence: 99%

“…5 There is no evidence that surgery improves the prognosis, and it should only be considered in cases with definitely decompensated hemodynamics. 1,4 We therefore chose the less invasive retroperitoneal tumor biopsy and chemotherapy at first. Conversely, chemotherapy administration should consider the risk of cardiac rupture or tumor embolization.…”

mentioning

confidence: 99%

“…1 Among them, solid heart-occupying manifestation is uncommon and occurs mainly in the right atrium, with pathological types of DLBCLs. 4 Multifocal lymphoma with cardiac involvement is associated with a high death risk. The prognosis of lymphoma with cardiac involvement has a 10% survival rate of 9-12 months if untreated.…”

mentioning

confidence: 99%

“…The prognosis of lymphoma with cardiac involvement has a 10% survival rate of 9-12 months if untreated. 4 Chemotherapy is a mainstay in treating B-cell non-Hodgkin's lymphoma with cardiac involvement to improve survival rate. 1,2,4 Tumor biopsy for histological assessment is therefore essential, and the location to obtain specimens is an issue.…”

mentioning

confidence: 99%

“…4 Chemotherapy is a mainstay in treating B-cell non-Hodgkin's lymphoma with cardiac involvement to improve survival rate. 1,2,4 Tumor biopsy for histological assessment is therefore essential, and the location to obtain specimens is an issue. In our case, open-heart surgery for the cardiac mass could have relieved mechanical blood flow obstruction; however, it was considered to be too invasive just to obtain a histological diagnosis.…”

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confidence: 99%

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Pediatric diffuse large B‐cell lymphoma requiring right atrial tumor resection

Kanai

Takachi

Ikai

et al. 2022

Pediatrics International

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confidence: 99%

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confidence: 99%

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Pediatric diffuse large B‐cell lymphoma requiring right atrial tumor resection

Kanai

Takachi

Ikai

et al. 2022

Pediatrics International

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Primary cardiac large B cell lymphoma

Arun Kumar,

Mishra,

Malempati

et al. 2023

BMJ Case Rep

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A female patient in her mid-60s presented with progressive shortness of breath, pleuritic chest pain and bilateral leg swelling for 1 week. Initial diagnostic workup revealed pericardial effusion, and a localised pericardial tubular mass on CT chest. Pericardial fluid analysis showed elevated white cells, with predominance of medium-large sized atypical lymphoid cells. Atypical lymphocytes stained positive for CD79a, CD10, PAX-5, BCL-2 and BCL6. Fluorescence in situ hybridisation testing demonstrated MYC and BCL6 rearrangements without BCL2 gene rearrangement. The overall morphological, immunohistochemical and cytogenetic findings supported a diagnosis of high-grade B cell lymphoma with MYC and BCL6 rearrangements. After extensive staging workup, localised disease involving the pericardium with a diagnosis of primary cardiac large B cell lymphoma was established. She was treated with dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin and rituximab chemotherapy. Rituximab was discontinued owing to largely absent CD20 expression. Interim positron emission tomography-CT after three cycles revealed a complete response, and the patient completed six cycles of therapy.

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A rare presentation of primary cardiac diffuse large B‑cell lymphoma: A case report

Jiang,

Liu,

Zhao

et al. 2023

Oncol Lett

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Primary cardiac lymphomas display a low frequency, sudden onset, swift progression of illness and elevated mortality rates. The current study presents a unique instance of primary cardiac diffuse large B-cell lymphoma and examines its clinical manifestations, pathological characteristics and differential diagnosis. A 64-year-old male patient sought medical attention due to cardiac debility and exertional dyspnea persisting for >10 days. Chest enhanced computed tomography revealed a moderately enhancing irregular mass in the ventricular area, exhibiting limited demarcation from the pericardium and left atrium, accompanied by irregular thickening of the interventricular septum. The postoperative specimen showed the presence of yellow fish-like tumor tissue. Immunohistochemical analysis revealed the presence of lymphocytes positive for CD20, BCL-2, BCL-6, c-Myc-binding protein, mutated melanoma-associated antigen 1 and CD79a, along with a high Ki-67 proliferation index of 80%. Conversely, CD10, CD30, CD3, pan cytokeratin, cyclin D1, desmin and vimentin marker results were found to be negative. Additionally, in situ hybridization demonstrated a lack of Epstein-Barr virus-encoded small RNA expression. The present case report emphasizes the significance of conducting a thorough analysis of the clinical manifestations of diffuse large B-cell lymphoma to assist clinicians in establishing a diagnosis and determining an effective treatment approach, thereby enhancing the patient's prognosis.

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Diffuse large B-cell lymphoma with uncommon cardiac invasion

Cited by 3 publications

References 17 publications

Pediatric diffuse large B‐cell lymphoma requiring right atrial tumor resection

Pediatric diffuse large B‐cell lymphoma requiring right atrial tumor resection

Primary cardiac large B cell lymphoma

A rare presentation of primary cardiac diffuse large B‑cell lymphoma: A case report

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