Diffuse Large B-cell Lymphoma of Testis: a Case Report and Current Literature Review

Abstract

Introduction: Testicular cancers detected in older males are mostly testicular lymphomas. Primary testicular lymphoma (PTL) is a rare, clinically aggressive form of extranodal lymphoma. In population-based studies, the  incidence of PTL is 0.09-0.26/100.000. The vast majority of PTL are diffuse large B-cell lymphoma (DLBCL).   Case presentation: We present a case of PTL diagnosed in a 68-year-old male patient and also, we discuss the incidence, clinical presentation, prognostic factors and management of this rare pathology in the light of current literature. Histopathological and immunohistochemical exams of the patient confirmed the diagnosis of DLBCL after radical orchiectomy. According to the internal prognostic index (IPI), patients’ IPI score was evaluated as 5 and according to Ann Arbor staging, patients’ stage was interpreted as grade 3E. Cyclophosphamide, vincristine, etoposide, and prednisolone chemotherapy was planned for the patient and until now, the patient received his first chemotherapy regimen.   Discussion: Primary testicular lymphoma should be kept in mind for every patient who admits with a testicular mass, especially in advanced age.  Misinterpreatation of the clinical findings can delay the definitive diagnosis. Primary testicular lymphoma should be managed with a multi-disciplinary team including urologists, medical and radiation oncologists. 

Development and validation of a survival nomogram in patients with primary testicular diffuse large B-cell lymphoma

“… 5 , 12 As such, PT-DLBCL research has been limited to case reports and small-sample retrospective studies. 13 – 15 Some clinical features such as patient age at diagnosis, stage, and absolute lymphocyte counts in the peripheral blood have been shown to be prognostic factors in PT-DLBCL. No specific prognostic score has yet been developed for PT-DLBCL.…”